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Earlier sources: Science
Science investigates the natural world through observation, experiments, and mathematical models. Explore papers and developments in biology, medicine, materials, neuroscience, physics, climate, and mathematics; a reported finding is not necessarily established consensus.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗1279 classified signals in the fourteen-day window. Recent momentum: steady. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- arXiv · Published · First archived
Energy Flow Shapes the Decomposition Dynamics of a Reactive Atmospheric Intermediate ↗
The unimolecular dynamics of Criegee intermediates depend strongly on their internal energy, which can differ substantially between nascent atmospheric species and laboratory-prepared reactants. Here, the decomposition dynamics of {\it anti-}CH$_3$CHOO are investigated using molecular dynamics simulations on a neural network-based potential energy surface under thermal and mode-selective vibrational excitation. Simulations were performed at internal energies representative of those released during ozonolysis (chemical/thermal preparation, TP) or following vibrational excitation (VibEx) along t…
- Hacker News · Posted on Hacker News · First archived
Call for stories: human–AI collaboration in recent mathematics ↗
Hacker News discussion.
- OpenAlex · Published · First archived
Machine-Learning-Based Genomic Prioritization and Genome-Wide Association Analysis of Growth Traits in Central Anatolian Merino Sheep ↗
Growth traits are major economic drivers in sheep production, yet their genetic architecture is highly polygenic and influenced by multiple genetic and environmental factors. Here, we integrated machine-learning-based genomic prioritization and prediction with conventional mixed-model genome-wide association analysis to investigate growth traits in Central Anatolian Merino sheep. Phenotypic records for birth weight (BW), weaning weight (WW), six-month weight (W6), and average daily gains before (ADWG1) and after weaning (ADWG2) were obtained from 278 lambs genotyped using the Illumina OvineSNP…
- OpenAlex · Published · First archived
Aspects of Symmetry in Nuclear Quantum Computing Variational Algorithms ↗
Variational Quantum Eigensolvers (VQEs) have become a standard tool for use in preparing eigenstates in quantum simulations of many-body systems. In the case of the nuclear shell model, various adaptations of the VQE have been shown to be able to produce ground and excited states of nuclei. The VQE algorithm works by seeking minima in a cost function, which is often the expectation value of the energy. For a well-formulated problem, symmetries that are respected by the Hamiltonian should appear in the final converged solution provided by the VQE, even if those symmetries are broken by the wave…
- OpenAlex · Published · First archived
Proximity‐Induced Protein Deglycosylation by Endogenous O‐GlcNAcase ↗
ABSTRACT O‐GlcNAcylation is an important post‐translational modification that regulates numerous cellular processes, yet tools enabling selective removal of O‐GlcNAc from individual proteins via endogenous O‐GlcNAcase (OGA) in living cells remain limited. Here, we report De‐O‐GlcNAcylation‐targeting chimeras (DOGTACs), a chemically induced proximity strategy that selectively reduces O‐GlcNAc from target proteins by recruiting endogenous OGA. Initial designs incorporating potent competitive OGA inhibitors efficiently engaged OGA but failed to induce de‐O‐GlcNAcylation, revealing that catalytic…
- OpenAlex · Published · First archived
Virus‐Induced Genome Editing in the Parasitic Plant Phtheirospermum japonicum ↗
Summary Statement Phtheirospermum japonicum is a genetic model for parasitic Orobanchaceae, a family that includes agriculturally important weeds such as Striga , Orobanche , and Phelipanche . Functional genetic studies in these species are limited by the lack of stable transgenesis protocols, restricting heritable CRISPR/Cas9 genome editing. This challenge is common to many non‐standard model plants and crops. Here, we combined Agrobacterium rhizogenes ‐mediated transformation with virus‐assisted delivery of the ultracompact TnpB nuclease to achieve stable, transgene‐free, heritable genome ed…
- OpenAlex · Published · First archived
Clinical and Molecular Spectrum of 1q21.1 Copy Number Variations: A Case Series ↗
Background: 1q21.1 copy number variations (CNVs) are recurrent rearrangements with a clinical spectrum, from neurodevelopmental disorders and congenital anomalies to apparently unaffected carrier status, reflecting incomplete penetrance and variable expressivity. Methods: Our chromosomal microarray (CytoScan HD) database was retrospectively screened for pathogenic or likely pathogenic 1q21.1 CNVs. Results: Twenty probands from 19 families (14 postnatal, 6 prenatal) carried 21 CNV events: 11 deletions (52.4%) and 10 duplications (47.6%). Of these, 16 (76.2%) were confined to the distal segment,…
- OpenAlex · Published · First archived
Draft genome sequence analysis of a multidrug-resistant Escherichia coli sequence type 3602 isolated from an equine placentitis lesion in Kentucky, USA ↗
ABSTRACT We report the draft genome sequence of a multidrug-resistant Escherichia coli isolate recovered from an equine placentitis lesion associated with late-term abortion. This genome expands available genomic resources for equine-associated E. coli and supports investigation of antimicrobial resistance in equine reproductive disease.
- OpenAlex · Published · First archived
Complete genome analysis of Enterococcus hirae S2 from the gut of Large-Tailed Han sheep reveals genomic potential for bacteriocin production and multidrug resistance risk ↗
The global spread of antimicrobial resistance (AMR) urgently calls for novel antibacterial lead compounds. The animal intestinal tract serves not only as a reservoir of resistance genes but also as an underexplored source of antimicrobial metabolites. Enterococcus hirae ( E. hirae ), a commensal gut bacterium, has not yet been systematically characterized with respect to the genomic potential for beneficial metabolite production and its associated resistance risk. Hybrid Illumina and PacBio sequencing was employed to determine the complete genome of E. hirae strain S2, isolated from the ileal…
- OpenAlex · Published · First archived
Complete genome sequence of Lactobacillus iners DSM 13336 determined by Oxford Nanopore Technologies long-read sequencing ↗
ABSTRACT Lactobacillus iners is a key member of the human vaginal microbiota. We present the complete genome sequence of strain DSM 13336, obtained with Oxford Nanopore Technologies. The obtained single circular chromosome (1,337,293 bp) offers a high-quality genomic resource for L. iners , underscoring the distinctive features of the DSM 13336 strain.
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