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Earlier sources: Science
Science investigates the natural world through observation, experiments, and mathematical models. Explore papers and developments in biology, medicine, materials, neuroscience, physics, climate, and mathematics; a reported finding is not necessarily established consensus.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗1311 classified signals in the fourteen-day window. Recent momentum: steady. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- OpenAlex · Published · First archived
Electrochemical Synthesis of Composites Based on Silicon and Carbon Nanotube Compounds as a Platform for Biocatalyst Development ↗
Progress in the field of modern heterogeneous catalysts requires the development of composite materials with a well-developed surface area and sorption capacity, as well as the possibility of functionalization in a specific direction. This paper presents the results of electrochemical synthesis of composites based on an organosilica matrix and multi-walled carbon nanotubes for subsequent application as a platform for enzyme immobilization. By potentiostatic electrodeposition, composite coatings based on two types of organosilica sol (STPEG and STEG) were applied to the surface of a glassy carb…
- OpenAlex · Published · First archived
Diagnostic Yield and Clinical Actionability of Genetic Testing in Neurodevelopmental Disorders: A Systematic Review and Meta-Analysis ↗
Genetic testing is increasingly central to the evaluation of neurodevelopmental disorders (NDDs), yet most evidence emphasises diagnostic yield rather than whether findings change clinical care. We conducted a systematic review and meta-analysis (Preferred Reporting Items for Systematic Reviews and Meta-Analyses [PRISMA] 2020) of genetic testing across the diagnostic pathway in NDD populations, focusing on autism spectrum disorder (ASD), intellectual disability, and global developmental delay, to quantify pooled diagnostic yield and clinical actionability. A systematic search of PubMed and Web…
- OpenAlex · Published · First archived
CRISPR‐Scan: Cas13a Mismatch Tolerance Enabled Ultra‐Multiplexed Detection of Same‐Site Indels in Acute Myeloid Leukemia ↗
ABSTRACT Detection of gene mutations related to acute myeloid leukemia (AML) is crucial for its early diagnosis, personalized treatment, and recurrence monitoring. However, accurate detection of diverse mutations occurring at the same locus remains technically challenging. The CRISPR/Cas system, with its unique programmable nucleic acid recognition capabilities, provides a promising solution. Here, we elucidated that CRISPR/LwaCas13a is tolerant to consecutive substitutions but highly sensitive to insertions or deletions (indels) at specific positions of the spacer sequence, enabling rational…
- OpenAlex · Published · First archived
Whole-genome sequencing reveals inter-household networks of gut-colonising ESBL-producing Escherichia coli in two rural Malawian districts ↗
Abstract Infection with extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-Ec) is a global health concern that disproportionately affects sub-Saharan Africa. Gut mucosal colonisation is thought to precede invasive infection. Understanding ESBL-Ec colonisation and transmission across communities is therefore essential. Here, we investigate the genomic epidemiology and spatial structure of 159 gut-colonising ESBL-Ec isolates from the faeces of 211 people in two rural Malawian villages using longitudinal sampling (2023–24), whole-genome sequencing and household mapping. Colonisatio…
- OpenAlex · Published · First archived
PG-MTCDGNet: A Physics-Grounded Multi-Scale Time-Lagged Dynamic Graph Network for Structured Evidence Reporting in Planetary-Gearbox Fault Diagnosis ↗
Multichannel vibration from a planetary gearbox exhibits operating-condition-dependent interactions across both time scale and lag. Static undirected graphs cannot represent ordered temporal dependence, while repeated graph aggregation can attenuate localized impacts. This paper presents PG-MTCDGNet, a physics-grounded multi-scale time-lagged dynamic graph network for structured evidence reporting in planetary-gearbox fault diagnosis. Phase-synchronous X/Y vibration, transient residuals, Hilbert envelopes, cross-channel coupling, and encoder micro-speed are represented as eight physical nodes.…
- OpenAlex · Published · First archived
PTM-PAL Pipeline: A Python Web Platform of Integrative Scoring System for Assessing the Functional Impact of Protein S-Palmitoylation ↗
S-palmitoylation is a reversible lipid modification that can alter protein localization, stability, interactions and signaling, but detection of a modified cysteine does not establish its functional importance. Post-translational Modification-Palmoylation Pipeline(PTM-PAL) is a web-accessible workflow for prioritizing candidate S-palmitoylation sites and modification configurations for functional follow-up. It integrates site-specific evolutionary context and UniProt annotation, paired wild-type and palmitoylated structural models, local protein-body solvent-accessible surface-area remodeling,…
- OpenAlex · Published · First archived
HDAC Inhibitors Potentiate Doxorubicin Cytotoxicity in HepG2 Cells and Alter DNA-Repair- and p53-Associated Transcriptional Programs ↗
Histone deacetylase inhibitors (HDACis) can enhance responses to DNA-damaging chemotherapy, but how they alter doxorubicin (DOX)-induced transcriptional programs remains incompletely understood. We investigated the effects of valproic acid (VPA) and vorinostat (SAHA) on DOX cytotoxicity and associated molecular responses in HepG2 cells. HDAC inhibition, cell viability, apoptosis, and DOX IC50 values were assessed using histone H3 acetylation, cell counting, Alamar Blue assays, and cleaved caspase-3 immunofluorescence. Transcriptomic responses were analyzed by RNA sequencing, differential expre…
- OpenAlex · Published · First archived
CRISPR-HAWK: Haplotype- and Variant-Aware Guide Design Toolkit for CRISPR-Cas ↗
Abstract Motivation Current CRISPR guide RNA design tools rely on reference genomes, overlooking how genetic variation impacts editing outcomes. As genome editing advances toward clinical applications, incorporating population diversity becomes essential for ensuring therapeutic efficacy across diverse populations. Results We present CRISPR-HAWK, a framework integrating individual- and population-scale variants and haplotypes into gRNA design. Analyzing therapeutic targets across 79,648 genomes reveals that genetic variants substantially alter guide performance. For the clinically approved sic…
- OpenAlex · Published · First archived
Thermotolerant Cyberlindnera jadinii Acquired by Adaptive Laboratory Evolution on Ethanol–Acetate for Improved Single-Cell Protein Production ↗
To obtain thermotolerant Cyberlindnera jadinii strains with high-efficiency utilization of ethanol–acetate carbon sources, serial-batch-transfer adaptive laboratory evolution (ALE) under 37 °C was performed on the wild-type strain C. jadinii TU389, and a thermotolerant evolved strain C. jadinii X131 was acquired. Results demonstrated that C. jadinii X131 exhibited superior biomass accumulation compared to the wild-type strain at both the optimal temperature of 31 °C and 37 °C. Specifically, the X131 strain showed 43.4% higher biomass and 45.1% higher protein yield than wild-type strain at 37 °…
- OpenAlex · Published · First archived
A high-quality telomere-to-telomere lumpy skin disease virus genome assembly ↗
Lumpy skin disease virus (LSDV) is an emerging livestock capripoxvirus (CaPV) that continues to cause substantial economic losses across Africa, Asia and Europe. However, important uncertainties remain regarding LSDV genome structure, particularly at the telomeric inverted terminal repeats (ITRs) that are central to host interaction, replication and adaptive evolution. Structural variation at the ITRs is driven by recombination during virus replication. Previous assemblies have relied primarily on short-read sequencing, which provides limited resolution of repeat-rich telomeric regions and pro…
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How to assess evidence about Science
Check each original source for its methods, release status, limitations, and supporting data. A repository announcement, a preprint, and a published study provide different kinds of evidence. SYMTRI’s subject classification helps discovery; it does not independently validate the source’s claims.
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