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Earlier sources: Science
Science investigates the natural world through observation, experiments, and mathematical models. Explore papers and developments in biology, medicine, materials, neuroscience, physics, climate, and mathematics; a reported finding is not necessarily established consensus.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗1326 classified signals in the fourteen-day window. Recent momentum: steady. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- OpenAlex · Published · First archived
Brain DNA methylation, APOE genotype and Alzheimer’s disease neuropathology in a large postmortem cohort ↗
Abstract DNA methylation (DNAm) plays a critical role in Alzheimer’s disease (AD). Previous epigenome-wide association studies using 450K arrays captured limited CpG coverage and often focused on a single neuropathological measure. Here we profiled DNAm in 1,250 postmortem prefrontal cortex samples from the Rush Alzheimer’s Disease cohorts using the Infinium MethylationEPIC v2 array (~930,000 CpGs) and performed epigenome-wide association studies of multiple neuropathologic measures, including AD diagnosis, amyloid-β and tau tangles. We identified 107 differentially methylated probes associate…
- OpenAlex · Published · First archived
Architect or Destroyer: The Diversity of Glucocorticoid Receptor Signaling Pathways in the Brain ↗
Glucocorticoids (GCs), acting through the glucocorticoid (GR) and mineralocorticoid (MR) receptors, are essential for brain development, stress adaptation, and metabolic homeostasis, yet their signaling exhibits context-dependent diversity yielding either beneficial or detrimental outcomes. This review synthesizes current knowledge on the multifaceted mechanisms through which GR integrates hormonal, metabolic, and stress signals to modulate transcriptional programs in the brain. We highlight three key levels of GR regulatory complexity: the diversity of DNA GR-binding motifs, GR-mediated epige…
- OpenAlex · Published · First archived
Development of REC1: A Reverse Vaccinology-Derived Multi-Epitope Vaccine Candidate Against Brucellosis ↗
Background/Objectives: Brucellosis is a widespread intracellular zoonosis that continues to impose substantial public-health and economic burdens in endemic regions. No human brucellosis vaccine has yet been approved, and most existing multi-epitope candidates rely solely on computational predictions, without population-specific human leukocyte antigen (HLA) optimization or in vivo epitope validation. REC1 is therefore an early-stage, proof-of-concept, human-oriented multi-epitope candidate, with epitopes screened against high-frequency HLA alleles in the Chinese population. This study develop…
- OpenAlex · Published · First archived
Diagnostic challenges in detecting the OXA-244 enzyme ↗
ABSTRACT Background OXA-244 is a β-lactamase capable of hydrolyzing carbapenems and belongs to the OXA-48-like family. Detection of OXA-48-like–producing Enterobacterales, including OXA-244, remains challenging in clinical microbiology laboratories, as isolates may demonstrate susceptibility to carbapenems despite producing a carbapenemase enzyme. Here, we describe a pediatric case of OXA-244–producing Escherichia coli and highlight the challenges and some practical considerations to improve the recognition and confirmation of OXA-48-like–producing Enterobacterales in clinical laboratories. Ca…
- OpenAlex · Published · First archived
Temporally Robust Machine-Learning-Assisted Impedance Line-Shape Analysis for Quantitative QCM Biosensing with DNA Hybridization Validation ↗
Liquid-phase quartz crystal microbalance (QCM) biosensors are commonly quantified using scalar readouts such as frequency shift, dissipation, or bandwidth. Although useful, these descriptors discard resonance line-shape morphology that carries additional information for quantitative inference. Here, we present a machine-learning-assisted impedance line-shape workflow for temporally robust quantitative 10 MHz QCM biosensing. A passive microfluidic mixer generated controlled glycerol–water concentration gradients under constant total flow while complex impedance spectra were acquired in real tim…
- OpenAlex · Published · First archived
Whole-Genome Sequencing in Diagnostics of Unsolved Cases of Inherited Retinal Diseases ↗
The study purpose was to assess the diagnostic value of whole-genome sequencing (WGS) in identifying candidate genetic variants in patients with inherited retinal diseases (IRDs). We investigated 107 unrelated Russian patients with retinal diseases who carried single pathogenic variants in any of nine common autosomal recessive IRD genes (ABCA4, USH2A, EYS, CRB1, RPE65, CNGB3, CNGA3, CEP290, and GUCY2D). WGS was performed for all patients; candidate splice variants were functionally validated using minigene assays. The total diagnostic yield was 40.2% (43/107). In 25.2% of cases (27/107), the…
- OpenAlex · Published · First archived
Role of Extrachromosomal Circular DNA in Sex Reversal of Monopterus albus ↗
Extrachromosomal circular DNA (eccDNA) serves as a vital regulator of gene expression and phenotypic plasticity. The Monopterus albus is a protogynous hermaphroditic fish, and the functional role of eccDNA during its female-to-male sex reversal remains poorly understood. We conducted Circle-seq analysis on gonadal tissues of super-female and male individuals and integrated our findings with previously published gonadal RNA-seq data. A total of 62,574 and 34,562 eccDNAs were, on average, identified in the two groups, and 7881 down-regulated and 2738 up-regulated differentially abundant eccDNAs…
- OpenAlex · Published · First archived
Integrated immunoinformatics-guided development and validation of an immunodominant multi-epitope vaccine candidate against lumpy skin disease virus ↗
Lumpy skin disease virus (LSDV), a transboundary Capripoxvirus , continues to threaten livestock productivity worldwide. Existing live-attenuated and inactivated vaccines are limited by safety concerns, incomplete protection, and poor compatibility with DIVA-based surveillance. Using an immunoinformatics workflow, we engineered and preliminarily validated a 14.3 kDa multi-epitope subunit vaccine based on the envelope protein P32 and surface protein A27L. Cytotoxic T-lymphocyte (CTL), helper T-lymphocyte (HTL), and B-cell epitopes were identified and rigorously filtered for antigenicity, non-al…
- OpenAlex · Published · First archived
Syncrip coordinates with hnRNPK to regulate PPV NS1 mRNA splicing and facilitate viral replication ↗
Porcine parvovirus (PPV) relies on alternative splicing of the nonstructural protein 1 (NS1) transcript to generate nonstructural protein 2 (NS2), but the host factors coordinating this process remain incompletely defined. Here, we identified heterogeneous nuclear ribonucleoprotein K (hnRNPK) as a regulator of PPV NS1-to-NS2 mRNA splicing in PK-15 cells. hnRNPK specifically associated with NS1 mRNA, and PPV infection increased hnRNPK expression in a time- and multiplicity-of-infection-dependent manner. hnRNPK overexpression decreased the NS1/NS2 mRNA and protein ratios and increased viral DNA…
- OpenAlex · Published · First archived
Natural Dyeing of Protein-Based Textiles with Prunus spinosa L. Fruit Extract: An Integrated Assessment of Dyeing Performance, Mordant Effects, and Dye-Bath Reuse ↗
Prunus spinosa fruit extract was investigated as a plant-derived coloring system for protein-based textiles by evaluating the effects of substrate, mordanting, dyeing conditions, and dye-bath pH. Knitted wool, woven wool, and silk were dyed without mordant or with alum or black tea biomordant and evaluated by K/S, CIELAB parameters, apparent dye-bath exhaustion, residual-bath reuse, and color fastness. Dyeing performance varied with substrate and processing conditions, with knitted wool consistently exhibiting the highest color strength. At 100 °C, extending dyeing from 1 to 3 h increased K/S…
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How to assess evidence about Science
Check each original source for its methods, release status, limitations, and supporting data. A repository announcement, a preprint, and a published study provide different kinds of evidence. SYMTRI’s subject classification helps discovery; it does not independently validate the source’s claims.
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