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Earlier sources: Science
Science investigates the natural world through observation, experiments, and mathematical models. Explore papers and developments in biology, medicine, materials, neuroscience, physics, climate, and mathematics; a reported finding is not necessarily established consensus.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗1345 classified signals in the fourteen-day window. Recent momentum: steady. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- OpenAlex · Published · First archived
Adaptation of suspension Vero cells to commercially available cell culture media and enhanced production of vaccine‐strain mumps virus ↗
Vero cells (referred to as "Vero" henceforth) are a commonly used host for the production of a wide variety of vaccines, but due in part to the typically anchorage-dependent nature of the cells, Vero cells also pose multiple challenges during process development, scale-up, and commercialization. The adaptation of Vero to proliferate in a serum-free suspension culture while remaining non-tumorigenic can be a challenging endeavor, and where successful, has often utilized undisclosed and/or complex custom-designed medium formulations. Additional and expanded options for commercially available ser…
- OpenAlex · Published · First archived
Data Quality and Predictive Reliability in AI-Enabled Aviation Energy Management: Physics-Informed Sensitivity Analysis with Open-Data Validation ↗
The objective of this study is to quantify how independently degraded operational-data quality affects predictive accuracy, predictive uncertainty, and prediction-level eligibility for decision support in AI-enabled aviation energy management. The evidence base combines a 24,000-flight physics-informed synthetic experiment, an independent distribution-shift experiment, a 17,520 h synthetic airport-energy time series, and external validation using 686 observed fuel-burn intervals from 79 flights and 10 aircraft types in the EUROCONTROL PRC 2025/OpenSky dataset. In the primary flight experiment,…
- OpenAlex · Published · First archived
Association mapping and genome prediction reveal a complex genetic architecture for resistance to black and frosty pod rot in cacao ( Theobroma cacao L.) populations ↗
Abstract Cacao ( Theobroma cacao L.) production is severely constrained by black pod rot (BPR) and frosty pod rot (FPR), two major diseases that cause substantial yield losses across the tropics. Breeding for disease resistance remains challenging due to long generation intervals and the complex genetic control of disease responses. Here, we used genome‐wide association studies (GWASs) and genomic prediction (GP) to dissect the genetic basis of BPR and FPR resistance in an interrelated multi‐parent F 1 panel comprising 495 individuals derived from eight bi‐parental crosses. Whole‐genome sequen…
- OpenAlex · Published · First archived
An IscS Persulfide Donates the Sulfur for Ribosomal Protein uL16 Thioamidation ↗
ABSTRACT Posttranslational sulfur incorporation into peptide backbones is increasingly reported. These efforts broaden our understanding of thioamides, which have distinct conformational and hydrogen‐bonding properties compared with amides. YcaO‐catalyzed thioamidation of the ribosomal protein uL16 reportedly occurs across thousands of Pseudomonadota. Here, we identify the cysteine desulfurase IscS, a crucial component of iron–sulfur cluster assembly, as the direct sulfur donor for uL16 thioamidation. Genetic deletion, in vitro reconstitution, kinetic analysis, sulfide scavenging, and mutation…
- OpenAlex · Published · First archived
Simulating Directed Evolution In Silico with an Iterative, Physics-Based Workflow ↗
Abstract Directed evolution consistently delivers engineered enzymes that facilitate diverse biocatalytic transformations. Despite advances in automation and high-throughput workflows, our ability to rapidly engineer novel enzymes is limited by our inability to thoroughly sample the vast protein design space. Generative artificial intelligence (AI) methods have alleviated this challenge to some degree, due to their ability to propose mutations based on learned patterns from complex protein data sets. However, the hidden logic of these AI-based methods can complicate our ability to reveal and e…
- OpenAlex · Published · First archived
Structural Variants in the Human Genome Associated With Gut Microbiome and Blood Metabolic Traits With Potential Causal Links ↗
ABSTRACT Research on genetic variants affecting the gut microbiome and blood metabolites has mainly focused on single nucleotide variants (SNPs), leaving structural variants (SVs) largely unexplored. Here, we analyzed high‐coverage (∼42×) whole‐genome sequencing data from 2002 individuals and constructed a catalog of 138 859 high‐confidence SVs, including 44.3% variants not represented in public SV resources. Genome‐wide association analyses of 22 519 common SVs identified 30 microbiome‐associated and 48 metabolite‐associated SV loci, including 19 study‐wide significant associations. Notable s…
- OpenAlex · Published · First archived
Fractional two-temperature dual-phase-lag bioheat transfer under electromagnetic heating: An analytical-physics-informed neural network framework ↗
This study develops a hybrid semi-analytical and physics-informed neural-network framework for transient thermoelastic heat transfer in biological tissue subjected to electromagnetic heating. The formulation combines a fractional two-temperature dual-phase-lag bioheat model with thermoelastic coupling, blood perfusion, temperature-dependent metabolic heat generation, and an effective Maxwell–Ohm Joule-heating source. The governing equations are solved in the Laplace domain and numerically inverted to generate reference temperature, displacement, and stress fields, which are subsequently used t…
- OpenAlex · Published · First archived
Load-dependent fault signature evolution in three-level NPC inverter-fed induction motor drives via physics-based characterisation ↗
Abstract Reliable detection of faults in inverter-fed induction motor drives depends on a precise understanding of how diagnostic signatures evolve across the full operating range. Most published fault characterisation studies, however, are conducted at a single operating point and do not formally distinguish between features whose diagnostic value holds across the load range and those confined to specific load conditions. This paper addresses that gap through a systematic, physics-based characterisation of fault signatures in a three-level neutral-point-clamped (NPC) inverter-fed squirrel-cag…
- OpenAlex · Published · First archived
Stable isotope‐derived measurements of protein synthesis detect amino acid‐induced anabolism in skeletal muscle microtissues not captured by puromycin labelling ↗
Skeletal muscle microtissues are valuable in vitro models for studying the stimuli regulating muscle protein synthesis (MPS), the key determinant of changes in muscle mass. Differentiated between opposing posts, microtissues contain aligned, contractile myotubes, providing a controlled system for investigating the responses of skeletal muscle to nutrient and contractile stimulation. However, microtissue MPS responses to these stimuli remain under-characterized. Stable isotope-labelled amino acid tracers deliver sarcoplasmic and myofibrillar fractional synthetic rates (FSR) for MPS in human stu…
- OpenAlex · Published · First archived
An ATP7A‐Mediated Endogenous Regulation Bio‐Clay Enzyme Enables Self‐Amplified Copper Accumulation for Immunogenic Pyrop ↗
ABSTRACT Tumor cells maintain abnormal metabolism to support their rapid proliferation, which often compromises the therapeutic outcomes, including pyroptosis. Inhibiting the copper transporter ATPase (ATP7A) effectively disrupts this metabolic balance, yet current exogenous ATP7A inhibition strategies suffer from poor delivery efficiency and low tumor selectivity. Herein, we developed an endogenous regulation strategy to downregulate ATP7A levels using a self‐amplifying bio‐clay enzyme (Bio‐Clayzyme), cupriferous Prussian blue/montmorillonite (CuPB/Mt). Upon tumor cell internalization, CuPB/M…
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How to assess evidence about Science
Check each original source for its methods, release status, limitations, and supporting data. A repository announcement, a preprint, and a published study provide different kinds of evidence. SYMTRI’s subject classification helps discovery; it does not independently validate the source’s claims.
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