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Earlier sources: Science
Science investigates the natural world through observation, experiments, and mathematical models. Explore papers and developments in biology, medicine, materials, neuroscience, physics, climate, and mathematics; a reported finding is not necessarily established consensus.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗1321 classified signals in the fourteen-day window. Recent momentum: steady. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- OpenAlex · Published · First archived
Clinical and Genetic Characterization of a Family with Tooth Agenesis Carrying a Novel LEF1 Variant ↗
Background: Tooth agenesis is one of the most common developmental anomalies of the human dentition and may occur either as an isolated trait or as part of a syndromic condition. Advances in genomic technologies have facilitated the identification of genes involved in odontogenesis, including LEF1 (Lymphoid Enhancer-Binding Factor 1), a key transcription factor in the WNT signaling pathway. Methods: Whole exome sequencing (WES) was performed in a proband with non-syndromic tooth agenesis to investigate the underlying genetic cause. Parental segregation analysis was performed through Sanger seq…
- OpenAlex · Published · First archived
Clinical significance, functional role and correlation with SEMA3B of long non-coding RNA SEMA3B-AS1 in gastric adenocarcinoma ↗
Abstract Background Gastric adenocarcinoma (GA) is a prevalent malignant tumor with poor prognosis owing to late diagnosis and high metastatic potential. Long non-coding RNAs (lncRNAs) are key regulators in GA initiation and progression, representing promising diagnostic and therapeutic targets. This study aimed to investigate the clinical significance, in vitro biological functions of lncRNA SEMA3B-AS1 in GA, and its expression correlation with the tumor suppressor gene SEMA3B. Methods Based on our previous lncRNA expression microarray data, lncRNA SEMA3B-AS1, which was downregulated in GA, w…
- OpenAlex · Published · First archived
JOUBERT SYNDROME: A CASE REPORT WITH AYURVEDIC CLINICAL PERSPECTIVE ↗
Background: Joubert syndrome (JS) is a rare genetically heterogeneous neurodevelopmental ciliopathy characterized by developmental abnormalities of the cerebellar vermis and brainstem, with variable neurological, ocular, skeletal, renal and hepatic manifestations. The characteristic neuroimaging finding is the molar tooth sign. Case presentation: A 9-year-old boy presented with severe global developmental delay, speech impairment, altered gait, truncal instability, head titubation, bilateral ptosis, drooling, obesity, dysmorphic facies and congenital bilateral six-finger polydactyly. Developme…
- OpenAlex · Published · First archived
VOICE-AE: automated CTCAE scoring from ambient clinical audio using speech recognition and large language models ↗
Abstract Treatment-related adverse event documentation is labor-intensive and subject to inter-observer variability. We developed and evaluated VOICE-AE, a multi-stage pipeline integrating automatic speech recognition, speaker diarization and large language models (LLMs) for automated extraction and grading of Common Terminology Criteria for Adverse Events (CTCAE) toxicities from clinician-patient audio recordings. Encounters of prostate cancer patients undergoing radiotherapy were recorded and processed through VOICE-AE. Six blinded human raters independently graded 10 genitourinary/gastroint…
- OpenAlex · Published · First archived
Multiparametric quantitative magnetic resonance imaging biomarkers associated with clinical phenotype in dystrophinopathies ↗
Dystrophinopathies are a group of inherited progressive myopathies marked by muscle weakness caused by genetic mutations, including Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), and intermediate muscular dystrophy (IMD). Existing clinical assessments demonstrate limitations in specificity and lack quantitative standards. This study evaluated the clinical value of quantitative magnetic resonance imaging (qMRI) in assessing dystrophinopathies. The qMRI technique combines fat fraction (FF), water T2 relaxation time (wT2), and diffusion-tensor imaging (DTI). A total of 42 par…
- OpenAlex · Published · First archived
Recent Results of Exotic Physics Searches at the CMS Experiment ↗
The LHC has recently completed its Run 3 data taking, marking the transition toward the High-Luminosity LHC era. While searches for physics beyond the Standard Model have already excluded many models at TeV scales, further gains from luminosity alone become increasingly limited. This motivates the development of new experimental and analysis techniques that can access signatures and phase-space regions beyond the reach of conventional searches. This review summarizes recent CMS searches for exotic physics, and then focuses on a selection of analyses that employ particularly novel strategies. T…
- OpenAlex · Published · First archived
Left Ventricular End‐Diastolic Diameter Predicts Clinical Outcomes in Patients Supported With Surgically Implanted Microaxial Flow Pump ↗
Background This study sought to determine the impact of left ventricular size on clinical outcomes after a microaxial flow pump was surgically implanted. Methods In this retrospective cohort study, we included patients who received a surgical microaxial left ventricular assist device from May 2020 to February 2024 at 2 high‐volume centers in the United States. Patients were categorized into 2 groups based on their preimplant left ventricular end‐diastolic diameter (LVEDD): “small LVEDD,” defined as LVEDD ≤5.5 cm, and “large LVEDD,” defined as LVEDD >5.5 cm, respectively. End points were all‐ca…
- OpenAlex · Published · First archived
Physics-Informed Transient Modeling of Methane Hydrate Transport Restrictions Using Petrobras 3W Offshore Well-Event Data ↗
Abstract Methane-dominant gas hydrate formation can restrict offshore production lines, alter pressure response, and interrupt natural-gas transport. Laboratory studies have established that hydrate growth depends on kinetic driving force, mass transfer, heat transfer, and hydrodynamic conditions, whereas field-data sets usually contain pressure, temperature, and flow signatures without direct hydrate-inventory measurements. This study presents a physics-informed framework for evaluating hydrate restriction signatures in offshore well data by combining robust field signal scoring with a one-di…
- OpenAlex · Published · First archived
Numerical Characterization and Experimental Optimization of Microfluidic DNA Microarray Hybridization ↗
Background/Objectives: Mathematical modeling and computational simulation are important tools in the analysis of fluid transport phenomena and surface reactions. These include surface hybridization that takes place in a microfluidic channel, creating a DNA microarray. Methods: In this work, the surface hybridization of target samples with multiple DNA probe spots immobilized on the bottom of a microfluidic channel was investigated using computational modeling. The model incorporates the 2D transport process, coupled with convective/diffusive mass transport (infinite dilution) and surface bindi…
- OpenAlex · Published · First archived
Engineering Protein Circuits for Cellular Control and Precision Immunotherapy ↗
Abstract Protein structural complexity confers responsiveness and modularity, allowing proteins to act as control modules in biomolecular circuitry. Protein engineering that commandeers native cell signaling and central dogma functions has led to the development of cell therapies, specialized biosensors, and a deeper understanding of cellular mechanisms. In this review, we examine how protein control modules command circuitry with therapeutic functionality across cellular spatial levels. Extracellularly, signal proteins such as antibodies and cytokines can provide either binary or gradient-sen…
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Check each original source for its methods, release status, limitations, and supporting data. A repository announcement, a preprint, and a published study provide different kinds of evidence. SYMTRI’s subject classification helps discovery; it does not independently validate the source’s claims.
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