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Earlier sources: Science
Science investigates the natural world through observation, experiments, and mathematical models. Explore papers and developments in biology, medicine, materials, neuroscience, physics, climate, and mathematics; a reported finding is not necessarily established consensus.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗1347 classified signals in the fourteen-day window. Recent momentum: steady. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- OpenAlex · Published · First archived
Genome-wide synthetic lethality screen of Bam complex-associated genes in Escherichia coli ↗
Abstract Biogenesis of the bacterial outer membrane is key to bacterial survival and antibiotic resistance. Central to this is the β-barrel assembly machine (Bam) complex and its associated chaperones, which are responsible for transport, folding and insertion of outer membrane proteins (OMPs). The Escherichia coli Bam complex is composed of two essential subunits, BamA and BamD, and three non-essential accessory lipoproteins, BamB, BamC and BamE. Optimal Bam function is further dependent on the non-essential periplasmic chaperones DegP, Skp and SurA. Despite intensive study, the specific func…
- Europe PMC · Published · First archived
Sex-dependent DNA methylation in amyotrophic lateral sclerosis ↗
Amyotrophic lateral sclerosis (ALS) shows well-established sex differences in incidence, age at onset and progression, but their biological basis is unclear. We hypothesised that the DNA methylation changes associated with ALS differ between the sexes, which would point to sex-specific disease processes. To test this, we performed a blood-based epigenome-wide association meta-analysis of ALS cases and controls from Project MinE, an international ALS genomics consortium, and an independent Australian cohort, comprising 8,946 individuals after quality control (5,129 males and 3,817 females; 8,94
- Europe PMC · Published · First archived
Heterochromatin protein 1α acts as an essential stabilizer of chromatin packing domains ↗
Background: : The spatial organization of the human genome emerges from an enzyme-guided self-assembly process in which chromatin has a bidirectional relationship with transcription. Central to this architecture are chromatin packing domains, 50-200 nm structures exhibiting mass-scaling behavior. Nascent domains arise through transcription and cohesin/CTCF-mediated loop extrusion, while their maturation depends on conditions that permit differential access of epigenetic enzymes to their dense cores and continuously lower density periphery, resulting in the accumulation of heterochromatic marks
- Europe PMC · Published · First archived
Unsupervised Clustering Enables Cohort-Specific Variant Recalibration in Crops ↗
Genomic selection (GS) and trait discovery in crops require reliable marker datasets, yet variant discovery remains constrained by the lack of standardised, high-confidence reference resources. Publicly available plant genomic resources are often based on outdated reference genomes, heterogenous pipelines, and generic variant hard-filtering thresholds derived from human studies. Consequently, implementation of the Genome Analysis Toolkit (GATK) Best Practices framework, including machine learning-based variant quality score recalibration (VQSR), remains challenging in crop genomes. Here, we pr
- Europe PMC · Published · First archived
Linking live-cell imaging to single-cell sequencing using genetic barcoding ↗
Linking cellular phenotype to genotype and gene expression is a central goal in biomedical research. Live-cell imaging captures dynamic cellular phenotypes, whereas single-cell sequencing measures genome-wide molecular states, but pairing these readouts for the same cell remains challenging. Here we present Waldo, a genetically encoded single-cell barcoding strategy that can be read out by both live-cell imaging and single-cell sequencing to connect single cells across both modalities. Waldo barcodes are generated by combinatorial expression of synthetic cell-surface receptors, each detected b
- Europe PMC · Published · First archived
Integrated GWAS and transcriptome analyses reveal candidate genes associated with betalain-related pigmentation under heat stress in Amaranthus tricolor ↗
Amaranthus tricolor is a climate-resilient orphan crop whose betalain pigments contribute to nutritional quality and stress tolerance. However, breeding efforts have traditionally relied on field yield trials due to the limited availability of genomic information and genetic resources. To address this gap, we first used the Illumina and PacBio sequencing platforms to assemble a novel reference genome of A. tricolor, using the Japanese cultivar Bayam. By combining this reference genome with a core collection developed in our previous study, we aimed to identify genomic regions associated with p
- Europe PMC · Published · First archived
The impact of sex and ancestry on the molecular landscape of pancreatic adenocarcinoma ↗
Background: Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second leading cause of cancer-related mortality, with an increasing incidence and dismal 10% survival at 5 years despite best available care. PDAC is characterized by low tumour cellularity, recurrent driver mutation alterations, and substantial inter and intra-tumoural heterogeneity. The influence of individual genetic features such as sex and ancestry on tumour heterogeneity remains poorly understood. Methods: We assembled a cohort of PDAC across five datasets for a total of 7,527 tumours. Measures of genomic ins
- Europe PMC · Published · First archived
Distilling Trial-Level EEG Variability into Participant Representations: Neurophysiologically Constrained Graph Learning in ADHD ↗
Extracting stable individual-level representations from noisy and variable trial-wise EEG remains a major challenge in computational cognitive neuroscience. We developed a spatiotemporal graph attention network to analyze Go/NoGo EEG from children and adolescents with and without ADHD. The framework combines ERP-informed temporal windows, phase-synchrony graph priors, and trial-to-participant transfer learning, making both information routing and representation geometry explicitly testable. The model learned reproducible attention trajectories, yet ADHD and control participants did not differ
- Europe PMC · Published · First archived
RiboWin: A computational framework to identify non-canonical open reading frames ↗
Abstract Ribosome profiling is widely used to map translation across the genome, yet current sORF discovery pipelines are constrained by their reliance on annotated protein coding regions and by treating biological replicates primarily as tools for quantification rather than as strict filters for reproducibility. This results in two major issues, the systematic exclusion of pseudogene derived loci from analysis and the generation of extremely large candidate sets in which true translation events are difficult to distinguish from noise. To overcome these limitations, a five-stage framework was
- Europe PMC · Published · First archived
Virus ΨM2 enters a non-lytic lifecycle alternative to lysogeny during infection of Methanothermobacter marburgensis ↗
Methanogens, a diverse group of archaea that produce methane during energy metabolism, are prevalent in anoxic habitats where they are exposed to viral infections. The head-tailed virus ΨM2 is one of few virus isolates that infect a methanogen host and was described as a lytic virus that lyses its host, Methanothermobacter marburgensis . Here, we present evidence that ΨM2 does not exclusively follow the classic lytic lifecycle but can also enter an alternative, chronic infection-like state. Growth experiments showed that infected cultures in minimal medium, optimized for the methanogen host (M
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