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Earlier sources: Science
Science investigates the natural world through observation, experiments, and mathematical models. Explore papers and developments in biology, medicine, materials, neuroscience, physics, climate, and mathematics; a reported finding is not necessarily established consensus.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗1340 classified signals in the fourteen-day window. Recent momentum: steady. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- OpenAlex · Published · First archived
Discovery of MYC/NSD3S Protein–Protein Interaction Negative Modulators with a Live Cell Nanoluciferase Protein-Fragment Complementation uHTS Assay ↗
Abstract Protein–protein interactions (PPIs) are central to physiological and pathophysiological processes. Identifying PPI modulators is the first step toward the development of new treatments. c-MYC (MYC), a key oncogene, interacts with NSD3S, stabilizing its structure and enhancing the oncogenic effect. In this work, we developed the NanoPCA assay in live cells in a 1536-well uHTS format to monitor the MYC/NSD3S PPI. We validated the platform by screening 12,000 compounds. The actions of several dose-dependent modulators were confirmed. Using orthogonal assays (immunoprecipitation, MYC repo…
- OpenAlex · Published · First archived
Readiness and challenges of developing countries in the global quantum revolution ↗
Quantum Education (QE) has gained worldwide importance due to the fast development of Quantum Information Science and Engineering (QISE). As per the strategy, quantum technology may spur innovation across industries and boost economic growth. Quantum computing research output and investment differ between developing and industrialized countries, highlighting the need for targeted efforts to close the gap. Consequently, while developed nations have advanced much in quantum research and development, underdeveloped countries still confront resource restrictions, limited infrastructure, and knowle…
- OpenAlex · Published · First archived
Complete mitochondrial genome of Arcuatula japonica (Mollusca: Mytilidae: Crenellinae) and its phylogenetic analysis ↗
Arcuatula japonica (Dunker, 1857) (Mollusca: Mytilidae: Crenellinae) is a marine mussel distributed primarily in the northwestern Pacific. To clarify its evolutionary position and evaluate the taxonomic status of Crenellinae, we sequenced and characterized the complete mitochondrial genome of A. japonica. The mitogenome is 16,198 bp in length and contains 13 protein-coding genes (PCGs), 22 transfer RNA genes (tRNAs), 2 ribosomal RNA genes (rRNAs), and 1 non-coding control region (CR), with an A + T bias (68.7%). Phylogenetic analysis based on 13 mitochondrial PCGs supports a sister relationshi…
- OpenAlex · Published · First archived
Physics-based finite element modelling of dynamic resistive switching in flexible HfO2 and Ta2O5 memristive devices ↗
Resistive switching (RS) in metal-oxides is governed by a complex interplay of electronic transport, thermal effects, and ionic migration within the bulk and at the interfaces of metal-insulator-metal (MIM) structures. Despite significant progress in experimental and theoretical understanding of RS, the coupled transient evolution of switching process remains inadequately understood. In this work, a coupled multiphysics finite-element model was developed by simultaneously solving governing equations for electronic transport, heat conduction, and oxygen-vacancy migration. The experimentally mea…
- OpenAlex · Published · First archived
Blood biomarkers identified with multi-omics combined with clinical and muscle imaging in oculopharyngeal muscular dystrophy ↗
Abstract Background Oculopharyngeal muscular dystrophy (OPMD) is an adult-onset, slowly progressive muscular dystrophy characterized by dysphagia, eyelid ptosis, and proximal limb weakness. Clinical trial readiness in OPMD requires development of sensitive indicators of disease progression and potential response to therapies in development. We used an untargeted multi-omics approach to identify circulating proteins, metabolites, and methylated DNA that could distinguish OPMD ( n = 31; age 62.5 ± 10.9 years; 13 GCN repeats in PABPN1 ; 48% female) from controls ( n = 17; age 57.2 ± 11.6 years; 7…
- OpenAlex · Published · First archived
Full-vectorial physics-informed neural operator for forward and inverse waveguide modeling ↗
Abstract In this work, we tailor Physics-Informed Neural Operators for full-vectorial modal analysis of optical waveguides. We develop a two-headed neural operator, conditioned on coordinate inputs alongside spatial material profiles and operational parameters. This enables a unified framework that simultaneously predicts the effective indices and the corresponding electromagnetic field distributions while preserving the discretization invariance of neural operators. To ensure stable training, we employ a normalized eigenvalue prediction strategy, enforced by construction and complemented by a…
- OpenAlex · Published · First archived
Rapid identification of porcine bacterial pathogens using an artificial intelligence Raman microbial analyzer for biology ↗
ABSTRACT Rapid and accurate identification of bacterial pathogens is critical for effective disease control in pig farms. Conventional bacterial culture-based and molecular diagnostic methods are time-consuming and often impractical for clinical decision-making. Raman spectroscopy, combined with artificial intelligence, offers a label-free alternative and provides isolate-level identification within approximately 2 min. The aim of this study was to evaluate the performance of the commercial Artificial Intelligent Raman Microbial Analyzer for Biology (AIRMAB) for the rapid clinical identificati…
- OpenAlex · Published · First archived
Auxin-inducible degron-mediated protein depletion in Diplonema papillatum ↗
Background Diplonemids are highly abundant unicellular flagellates that are evolutionarily divergent from traditional model eukaryotes. Diplonema papillatum is a model diplonemid for which several molecular tools have recently been established. However, no method for conditional protein depletion was available. Methods Here, we have adapted an auxin-inducible degron (AID) system in D. papillatum. Results Depletion of the KIN-A motor protein (a glycomonad-specific component of the chromosomal passenger complex) causes defects in chromosome segregation and cell proliferation. The AID system also…
- OpenAlex · Published · First archived
Effects of DNA Supercoil Handedness on Catalytic Inhibition of Mycobacterial Gyrase by Gepotidacin ↗
Abstract Gepotidacin, the first-in-class triazaacenaphthylene antibacterial, kills bacteria by stabilizing DNA cleavage complexes and inhibiting the catalytic activities of the type II topoisomerases, gyrase and topoisomerase IV. Mycobacterial species encode gyrase as their sole type II topoisomerase, meaning that inhibition of this enzyme blocks several essential cellular functions through a single target. Unlike fluoroquinolones and spiropyrimidinetriones, which inhibit gyrase by inserting two drug molecules, one at each of the cleaved scissile bonds, gepotidacin intercalates a single molecu…
- OpenAlex · Published · First archived
Fabrication of dynamic tetrahedral DNA structure probe for precision imaging and surgical navigation of oral and maxillofacial tumors ↗
Oral and maxillofacial tumors severely impair patients’ facial morphology and physiological functions, while conventional imaging methods suffer from low sensitivity, limited resolution and imaging artifacts, failing to support precise clinical diagnosis and accurate surgical navigation. To address these issues, this study innovatively combines tetrahedral DNA nanostructures (TDNs) with FISH technology to fabricate a dynamic DNA nanoprobe. With nucleolin and microRNA-21 as dual targets, the study systematically validates the probe’s detection performance in vitro and in vivo using tumor-bearin…
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How to assess evidence about Science
Check each original source for its methods, release status, limitations, and supporting data. A repository announcement, a preprint, and a published study provide different kinds of evidence. SYMTRI’s subject classification helps discovery; it does not independently validate the source’s claims.
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