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Earlier sources: Science
Science investigates the natural world through observation, experiments, and mathematical models. Explore papers and developments in biology, medicine, materials, neuroscience, physics, climate, and mathematics; a reported finding is not necessarily established consensus.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗1348 classified signals in the fourteen-day window. Recent momentum: steady. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- OpenAlex · Published · First archived
Estimation of Critical Distances for Electronic Detonators Using a Physics-Based Model ↗
Prior estimation of the distance at which detonation pressure reaches a critical threshold is relevant for defining borehole separations and reducing the risk of damage to electronic detonators in underground mining. Empirical attenuation relationships require site-specific calibration through instrumentation, limiting their application at preliminary design stages. A physics-based formulation is proposed that integrates detonation pressure, explosive–rock impedance matching, and equivalent rock mass stiffness to estimate transmitted pressure and critical distance. Attenuation is represented b…
- OpenAlex · Published · First archived
Unraveling RP1 -Associated Retinal Dystrophies: Comprehensive Genetic, Clinical, and Disease Progression Analysis in China ↗
Purpose: To characterize the clinical manifestations, genetic landscape, and natural history of RP1-associated retinopathy in a Chinese cohort. Methods: This longitudinal cohort study enrolled and followed 49 patients with genetically confirmed RP1-associated retinopathy. Phenotyping included visual acuity (VA), visual field, full-field stimulus testing (FST), microperimetry, and multimodal imaging. Genetic analysis and variant interpretation followed American College of Medical Genetics and Genomics and Association for Molecular Pathology guidelines. Results: The cohort predominantly presente…
- OpenAlex · Published · First archived
Multigenerational stability and environmental safety of transgenic rice expressing a dimeric HN protein as a plant bioreactor for poultry Newcastle disease vaccine antigen production ↗
Abstract Newcastle disease (ND) remains among the most economically important viral diseases in poultry, and novel thermostable, low-cost and genotype VII-matched veterinary vaccine platforms are urgently needed to overcome the limitations of conventional vaccines, such as cold chain dependency, high application cost and insufficient cross-protection against prevailing genotype VII strains. Rice endosperm has emerged as an ideal plant bioreactor for veterinary vaccine antigen manufacturing owing to its low production cost, cold chain-independent antigen storage, high biomass yield and great po…
- OpenAlex · Published · First archived
Clinical Trial Landscape of Duchenne Muscular Dystrophy in Europe: A 10-Year Retrospective Analysis ↗
Background and Objectives: Duchenne muscular dystrophy (DMD) is a rare and progressive genetic disease with limited treatment options. Clinical trials remain essential for the development of new therapies and may provide patients with access to new potential treatments. This study aims to describe the clinical trial landscape for DMD therapies in the European Union and European Economic Area (EU/EEA) between 2016 and 2026. Materials and Methods: A retrospective descriptive analysis was conducted using publicly available data from EudraCT and the Clinical Trials Information System (CTIS). Inter…
- OpenAlex · Published · First archived
CAMMA : A Physics‐Informed Adaptive Mamba Framework for Remaining Useful Life Prediction in Intelligent Predictive Maintenance ↗
ABSTRACT Rolling bearings are one of the most failure‐prone components in rotating machinery, and intelligent predictive maintenance relies on accurate estimation of their remaining useful life (RUL) from vibration measurements. However, the measured vibration is masked by strong noise and is nonmonotonic. Once a defect occurs, its distribution will change sharply, and the monitoring record of a full life cycle is long, so it is difficult to obtain a stable degradation trend and a reliable maintenance cycle. We present CAMMA, a physically adaptive Mamba framework with multihead attention that…
- OpenAlex · Published · First archived
Whole-genome profiling of hereditary cancer risk in a highly admixed cohort from Northeast Brazil: clinical, genomic, and ancestry findings ↗
Hereditary cancer syndromes account for 5–10% of all cancers, yet access to genetic testing remains limited in many low- and middle-income countries, including Brazil. The contribution of clinical and population factors to diagnostic outcomes remains poorly understood in admixed populations. This study investigated the socio-demographic, clinical, and genomic characteristics of 400 individuals at risk for hereditary cancer recruited at a Reference Service for Rare Diseases in Salvador, Bahia, Brazil, who underwent germline whole-genome sequencing through the Brazilian Rare Genomes Project. Par…
- OpenAlex · Published · First archived
Spontaneous mutation rate estimation in the large-genome unicellular eukaryote Euglena gracilis ↗
Abstract The spontaneous mutation rate per nucleotide (µ) is a fundamental parameter shaping genome evolution, yet it remains unknown for many eukaryotic groups. Here, we estimated µ in the freshwater unicellular eukaryote Euglena gracilis, which possesses a 2.4 Gb genome, among the largest reported for unicellular species. We conducted a mutation accumulation experiment using 10 independent MA lines propagated through repeated single-cell bottlenecks and then identified 153 de novo nucleotide mutations. After correction for false negatives, the spontaneous mutation rate was estimated at µ=6.6…
- OpenAlex · Published · First archived
Structure and Function of Archaeal SRP54 Protein Mutants Associated with Human Severe Congenital Neutropenia ↗
Abstract SRP54, a key component of the signal recognition particle, is a highly conserved enzyme both structurally and functionally. The protein plays a vital role in cellular protein translocation by interacting with the translating ribosome and a membrane receptor, thereby aiding protein folding and trafficking. Recent studies have shown that mutations in the SRP54 gene cause severe neutropenia and are associated with an increased risk of pediatric leukemias. Here, we present high-resolution structures of clinically relevant SRP54 mutant proteins from the archaea Pyrococcus furiosus. This wo…
- OpenAlex · Published · First archived
Hyperphagia in Prader–Willi syndrome: linking hypothalamic dysfunction to clinical assessment and management across the lifespan ↗
Abstract Background Prader–Willi syndrome (PWS) is a rare genetic neurodevelopmental disorder characterised by hypothalamic dysfunction and profound dysregulation in hunger and appetite regulation, endocrine function, metabolism and behaviour. Hyperphagia is a defining clinical feature and a major contributor to morbidity, mortality and caregiver burden. Increasing evidence suggests that hyperphagia in PWS represents a multidimensional disorder rather than excessive appetite alone. Results In December 2024, an international meeting of clinical and scientific experts was convened in Toulouse, F…
- OpenAlex · Published · First archived
Expanding the clinical spectrum of recessive CRX-associated retinal disease: an early-onset retinal dystrophy phenotype ↗
Abstract Objective To characterize the clinical and genetic findings in three affected siblings from a consanguineous family with a novel homozygous CRX variant and an early-onset retinal dystrophy (EORD) phenotype, and to review previously reported cases of recessive CRX -associated retinal disorders. Methods Comprehensive ophthalmic examinations, including visual acuity testing, fundus photography, optical coherence tomography, and full-field electroretinography when available, were performed in all participants. Whole-exome sequencing (WES) was carried out on the affected individuals, follo…
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