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Earlier sources: Science
Science investigates the natural world through observation, experiments, and mathematical models. Explore papers and developments in biology, medicine, materials, neuroscience, physics, climate, and mathematics; a reported finding is not necessarily established consensus.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗1397 classified signals in the fourteen-day window. Recent momentum: steady. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- Europe PMC · Published · First archived
Organizing principles of the cellular electron economy ↗
Life runs on electron flow. Cells extract electrons from nutrients and transfer them through metabolism, coupling carbon use to energy conservation, biosynthesis and redox homeostasis. Yet how and even whether electron flow is organized at the system-level across metabolism remain unknown. Here we formalize the concept of the cellular electron economy: a quantitative, genome-wide, reaction-resolved representation of electron generation, transfer and disposal. This electron-centric perspective reveals a quantitative relationship governed by two distinct organizing factors: the carbon source set
- Europe PMC · Published · First archived
A new mouse model for a high-risk AMD variant, ARMS2A69S ↗
Age-related macular degeneration (AMD) is the leading cause of irreversible central vision loss in older adults. The highest genetic risk for AMD maps to Chromosome 10q26. However, due to strong linkage disequilibrium between two genes, ARMS2 and HTRA1 located in this region, it has been difficult to determine whether one or both genes contribute to the AMD-disease risk. Functional studies of ARMS2 have been hampered due to the lack of animal models, as orthologs are only found in the higher primates and the gene is absent in rodents. To model ARMS2 biology in vivo, we used CRISPR-Cas9 to inse
- Europe PMC · Published · First archived
Genetic support for an adverse effect of calcium channel blockers on the human thoracic aorta ↗
Despite the widespread use of L-type calcium channel blockers (CCBs), recent observational and murine functional work has suggested a potential adverse effect of this medication class on the aorta. Here, we apply a Mendelian randomization (MR) framework to assess the potential causal role of CACNA1C - the principal target of L-type CCBs in the human aorta - on thoracic aortic aneurysm and dissection (TAA/D). Genetic instrumental variables were derived from aortic expression quantitative trait locus data, and combined with large-scale genome-wide association data of TAA/D and ascending aortic d
- Europe PMC · Published · First archived
Latent Genetic Factors and Causal Pathways Linking Substance Use to Psychiatric and Personality Phenotypes: a Genomic SEM and Mendelian Randomization Study ↗
Substance use and psychiatric disorders frequently co-occur, but establishing causality of their relationships is difficult given the multifactorial nature of these traits. To assess these relationships, we applied two genetically informed methods using the largest available European-ancestry genome-wide association studies of six substance use behaviors and twelve psychiatric and personality phenotypes. Using Genomic Structural Equation Modelling, we modelled the latent genetic architecture of the psychiatric and personality traits and examined these factors' correlations with substance use t
- Europe PMC · Published · First archived
Cell type specific enrichment of substance use and substance use disorder heritability ↗
Genome-wide association studies (GWAS) have identified numerous loci associated with substance use disorders (SUDs). To connect common genetic variation to cell type- and region-specific gene expression and chromatin accessibility, we examined the enrichment of genetic liability for several SUDs (alcohol, cannabis, tobacco, and opioid use disorders) and substance consumption phenotypes (drinks per week, cannabis ever-use, and cigarettes per day) in available single-nucleus RNAseq data spanning 10 brain regions and snATACseq data spanning 42 brain regions. Significant cell-type enrichment after
- Europe PMC · Published · First archived
Overcoming a diagnostic blindspot: Identifying balanced translocations in Mendelian rare disease cohorts ↗
Background: Short-read genome sequencing generates the signal necessary to detect balanced reciprocal translocations at single-nucleotide resolution, but standard structural variant callers represent them as breakend pairs. Structural variant callers produce thousands of breakend records per genome, the majority of which are false positives arising from segmental duplications, repetitive elements, and reference assembly artifacts. This specificity problem has prevented balanced translocation detection from entering routine genome sequencing workflows. We developed a highly specific pipeline to
- Europe PMC · Published · First archived
Convergent genetic and functional evidence implicate KCND3 in Brugada Syndrome ↗
Background: Dysfunction of the KCND3-encoded Kv4.3 channel, which carries the transient outward potassium current (Ito), has long been suspected to contribute to the pathophysiology of Brugada Syndrome (BrS). Although recent genome-wide association studies (GWAS) have implicated KCND3, the role of rare variation in this gene remains uncertain and clinically unactionable. Methods: Genome sequencing was performed in 983 BrS probands from Europe and Thailand. Putative gain-of-function (GoF) rare variants in KCND3 identified in patients were functionally characterized by patch-clamp analysis of Kv
- Europe PMC · Published · First archived
Population structure and sampling shape genomic antimicrobial resistance patterns in 30,327 Clostridioides difficile genomes ↗
Background: Large collections of publicly available bacterial genomes can be used to examine antimicrobial resistance (AMR), but estimates from such collections may be influenced by over-representation of particular lineages and by the method used to identify resistance markers. These effects were examined in a large collection of Clostridioides difficile genomes. Methods. All Clostridioides difficile GenBank assemblies available on 20 August 2026 were identified. After exclusion of NCBI-flagged atypical or metagenome-assembled records, application of four assembly-quality thresholds adapted f
- Europe PMC · Published · First archived
Attachment-Informed Leadership (AIL): A New Leadership Framework based on Attachment Theory and Social Neuroscience ↗
Leadership research has catalogued many styles, among them transformational, authentic and servant leadership, but has offered few accounts of the regulatory mechanisms through which leader-follower relationships operate. We propose that attachment, understood through social neuroscience, supplies one such mechanism. Humans regulate environmental demands relationally, and attachment organises this social regulation of a finite bioenergetic budget under challenge. When followers face threat, dependence or uncertainty, this relationship can come to serve attachment functions, and the leader's re
- Europe PMC · Published · First archived
Attention in model-based cognitive neuroscience: Mechanisms for optimization under constraint ↗
Two major criticisms of attention research are: 1) verbal theories lack the specificity to make falsifiable predictions about how the various mechanisms of attention operate; and 2) the term ``attention’’ is frequently ascribed to conceptually similar phenomena despite dissociable neural underpinnings. The field of model-based cognitive neuroscience is well-positioned to address (1) through mathematical formalization of hypothesized processes, but may perpetuate (2) insofar as similar algorithms and parameters may recur across modeling traditions without necessarily drawing upon a shared neuro
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Check each original source for its methods, release status, limitations, and supporting data. A repository announcement, a preprint, and a published study provide different kinds of evidence. SYMTRI’s subject classification helps discovery; it does not independently validate the source’s claims.
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