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Earlier sources: Science
Science investigates the natural world through observation, experiments, and mathematical models. Explore papers and developments in biology, medicine, materials, neuroscience, physics, climate, and mathematics; a reported finding is not necessarily established consensus.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗1400 classified signals in the fourteen-day window. Recent momentum: steady. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- Europe PMC · Published · First archived
White matter hyperintensities partly mediate genetically predicted blood pressure effects on vascular dementia ↗
Abstract Background White matter hyperintensities (WMH) mark cerebral small vessel disease and sit on the path from hypertension to vascular dementia (VaD). Prior Mendelian randomization in European ancestry has linked blood pressure (BP) to WMH. We tested whether that association replicates in Japanese ancestry and whether WMH captures part of the genetically predicted BP effect on VaD after a priori APOE exclusion. Methods Two-sample Mendelian randomization used European genome-wide association studies of BP, WMH, and VaD, with Japanese replication of BP residual to WMH residual. The primary
- Europe PMC · Published · First archived
Beethoven's genome shows elevated genetic susceptibility to otosclerosis ↗
Abstract Background Otosclerosis remains an unconfirmed explanation for Beethoven’s progressive deafness. We assessed susceptibility signals in his published genome. Methods A quality-filtered 138-site otosclerosis score and related 13-locus GWAS score were compared with 503 contemporary European reference individuals. Sensitivity and historical-clinical evidence were appraised. Three AHSG variants underwent targeted genotype and reference-panel comparison. Results Beethoven ranked at the 96.02nd and 95.83rd empirical percentiles; a post-hoc composite ranked at the 98.01st. Excluding five infl
- Europe PMC · Published · First archived
Quantitative gene-level inference of tumor transcription from plasma epigenomes ↗
Abstract Tumor phenotype and therapeutic vulnerability are shaped by dynamic transcriptional states that are not captured by genetic profiling alone and are difficult to monitor longitudinally. Existing plasma-based approaches have largely been developed using samples with high circulating tumor DNA fractions, evaluated across expression quantiles rather than individual genes, and rarely benchmarked head-to-head. Using timepoint-matched plasma epigenomes and tumor transcriptomes, we identify biologically grounded relationships between circulating chromatin, fragmentation, and transcription. H3
- Europe PMC · Published · First archived
KIF3A as a transcriptomic marker of ciliation status in human striatal parvalbumin interneurons: single-cell evidence linking intraflagellar transport to the LRRK2-Rab-ciliogenesis axis ↗
Abstract Pathogenic LRRK2 mutations disrupt Rab GTPase signaling and impair primary ciliogenesis, attenuating Sonic Hedgehog (Shh) trophic support critical for striatal neuron survival. While imaging studies have established cell-type-selective cilia loss in LRRK2 mutant models, transcriptomic evidence identifying the molecular correlates of ciliation status at single-cell resolution remains limited. We analyzed 22,048 cells from human striatal tissue (GSE197140) to identify genes associated with ciliation status across neuronal subtypes. Using within-cell-type median splits on computed ciliat
- Europe PMC · Published · First archived
Urban Genomics in a Rapidly Urbanizing Megacity Reveals Layered Cardiometabolic Genetic Architecture ↗
Abstract Rapid urbanization has reshaped human population structure, yet its impact on genetic architecture and disease risk remains poorly understood. Here, we present the S hanghai H uman AN cestry and G enomic H ealth A tlas I nitiative (SHANGHAI), a genomic resource comprising 1,016 individuals with high-coverage whole-genome sequencing (48.6×) integrated with multi-omics and clinical data, representing a rapidly urbanizing megacity population. We identified 43.2 million genetic variants, including 7.08 million previously unreported variants and over 100,000 structural variants, with subst
- Europe PMC · Published · First archived
Engineering of CRISPR-BrCas12b System for Efficient Genome Editing in Thermophilic Bacteria ↗
Abstract The development of synthetic biology has brought new opportunities for green manufacturing. A growing number of non-model bacteria are increasingly harnessed as chassis organisms based on their unique physiological features. The thermophilic microorganism Thermus antranikianii holds great potential as a next-generation cell factory, yet its exploitation is constrained by the lack of genetic engineering tools. Here we report a thermostable CRISPR-BrCas12b-based gene editing tool for this thermophile. The BrCas12b mediates precise target recognition and cleavage at 45–70°C, matching the
- Europe PMC · Published · First archived
Integrative bioinformatics prioritises exosome-associated Epstein- Barr virus microRNA targets in gastric cancer ↗
Abstract Background Epstein-Barr virus (EBV)-associated gastric cancer (EBVaGC) is characterised by substantial immune-cell infiltration and frequent amplification or overexpression of programmed death (PD)-ligand 1 and PD-ligand 2. Nevertheless, the molecular mechanisms that may contribute to immune regulation in this cancer subtype remain incompletely understood. EBV-positive SNU719 gastric cancer cells produce BamHI-A rightward transcript (BART) microRNAs (miRNAs), some of which are packaged into exosomes while also remaining detectable in the parental cells. This study aimed to identify EB
- Europe PMC · Published · First archived
KIF18A inhibition enhances glioma response to radiotherapy through activation of cGAS–STING signaling ↗
Abstract Background Radioresistance remains a major cause of glioma recurrence, highlighting the need for therapeutically actionable radiosensitizing targets. Kinesin family member 18A (KIF18A), a mitotic motor protein essential for the survival of chromosomally unstable tumor cells, has emerged as a promising therapeutic target. However, its role and underlying mechanisms in regulating glioma radiosensitivity remain poorly understood. This study aims to evaluate the therapeutic potential and mechanisms of KIF18A inhibition combined with radiotherapy in glioma. Methods Integrated analyses of t
- Europe PMC · Published · First archived
NK2R signaling governs intestinal lipid mobilization and mucosal inflammation. ↗
Neuropeptidergic control of lipid metabolism is conserved and increasingly implicated in metabolic diseases, but receptor-level mechanisms remain unclear. Here, we identify the neurokinin-2 receptor (NK2R) as a central node linking tachykinin signals to intestinal lipid mobilization, epithelial composition, and mucosal inflammation. Across complementary genetic and pharmacological perturbations, modulation of NK2R drives bidirectional effects. Loss or blockade of NK2R increases postprandial triglyceridemia and expands intestinal lipid stores, whereas agonism suppresses chylomicron output, redu
- Europe PMC · Published · First archived
Double-crystallized GOx-entrapped copper nanoflowers enabling interfacial cascade catalysis for electrochemical glucose sensing. ↗
Artificial enzyme-nanozyme cascade systems that enable interfacial coupling between biocatalytic and inorganic redox processes are of significant interest for biointerface engineering. In this study, a double-crystallized Cu nanoflower-based enzyme-nanozyme cascade platform was introduced by immobilizing GOx-integrated Cu nanoflowers (D-Cu@GOx NFs) onto an electrode surface. The double-crystallization process generates a hierarchical Cu nanoflower architecture that spatially confines enzyme and nanozyme components, enabling proximity-driven cascade catalysis through a redox-active Cu framework
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Check each original source for its methods, release status, limitations, and supporting data. A repository announcement, a preprint, and a published study provide different kinds of evidence. SYMTRI’s subject classification helps discovery; it does not independently validate the source’s claims.
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