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Earlier sources: Science
Science investigates the natural world through observation, experiments, and mathematical models. Explore papers and developments in biology, medicine, materials, neuroscience, physics, climate, and mathematics; a reported finding is not necessarily established consensus.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗1445 classified signals in the fourteen-day window. Recent momentum: steady. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- Europe PMC · Published · First archived
Construction of red-spotted grouper nervous necrosis virus (RGNNV) nonstructural protein B1/B2 mutant strains and dynamics during infection. ↗
Nervous necrosis virus (NNV) is a neurotropic pathogen that causes serious losses in aquaculture worldwide. B1 and B2 proteins, nonstructural proteins of NNV, play vital roles in viral function. In this study, a plasmid-based reverse genetics system was established for red-spotted grouper nervous necrosis virus (RGNNV), and codon mutations on B1 and B2 proteins were introduced. One recombinant virus (recomb) and five mutant viruses (B1QM, B2QM, BoQM, B1JM, and B2JM) were successfully rescued. Mature virions of approximately 30 nm in diameter within intracellular vacuoles were observed under tr
- Europe PMC · Published · First archived
Loss of Cotl1 disrupts mitochondrial fission and impairs learning and memory in mice. ↗
Mitochondrial morphology dynamics are essential for neuronal function and are regulated by fission and fusion machinery, in which the actin cytoskeleton plays a crucial role. Coactosin-like F-actin-binding protein 1 (Cotl1), a key component of the actin cytoskeleton, is gaining attention for its profound pathophysiological implications in human neurodegenerative disorders. However, its role in neuronal function remains unclear. Therefore, we aimed to explore the role of Cotl1 in mitochondrial morphology and neuronal dysfunction. We generated Cotl1-knockdown and Cotl1-K75E mutants to examine mi
- Europe PMC · Published · First archived
Therapeutic potential of proline-rich peptide-1 (PRP-1) in counteracting amyloid-β-mediated cortical and hippocampal neurodegeneration in a rat model. ↗
Alzheimer's disease (AD) is associated with amyloid β (Aβ) accumulation, neuronal metabolic dysfunction, and structural degeneration. This study compares the neurotoxic effects of Aβ25-35 and Aβ1-42 in the rat cerebral cortex and hippocampus and evaluates the neuroprotective potential of proline rich peptide 1 (PRP-1). Amyloid peptides were administered bilaterally into the lateral ventricles, followed by intramuscular PRP-1 at 0.1 mg/kg once daily for three weeks, beginning 24 h after amyloid administration. Neuronal metabolic activity was assessed by Ca2⁺ dependent acid phosphatase histochem
- Europe PMC · Published · First archived
Kidney-specific cell-free DNA as biomarker of kidney injury: Development and exploration of a multiplex digital droplet PCR assay. ↗
Cell-free DNA (cfDNA) is a promising non-invasive biomarker of organ injury. In transplantation, cfDNA is typically quantified by distinguishing donor- from recipient-derived DNA. However, we aimed to develop a multiplex digital droplet PCR (ddPCR) assay to measure kidney-derived cfDNA independent of donor-recipient differences as a marker of kidney injury. Five kidney-specific differentially methylated regions were identified in silico using The Cancer Genome Atlas and Gene Expression Omnibus data and combined into a multiplex ddPCR assay. The assay was validated in kidney implantation biopsi
- Europe PMC · Published · First archived
Centrally administered SGLT2 inhibitor improves gut barrier function through the brain orexin, AMPK, dopamine D2 signaling and the vagal pathway in rats. ↗
Leaky gut, defined as increased intestinal permeability, has been associated with many diseases. Recent studies suggest the brain is involved in maintaining gut barrier function. Since tofogliflozin, a sodium/glucose cotransporter 2 (SGLT2) inhibitor acts centrally to increase food intake, and feeding and gut functions are deeply associated, this study aimed to clarify the hypothesis that gut barrier function is influenced by centrally administered SGLT2 inhibitors in rats using Evans blue method. Intracisternal SGLT2 inhibitor blocked colonic hyperpermeability in response to lipopolysaccharid
- Europe PMC · Published · First archived
Dielectric-Modulated Nanogap Engineered AlGaN/GaN MOSHEMT: A High-Performance Platform for Neutral and Charged Biomolecule Detection. ↗
This work presents a dielectric-modulated AlGaN/GaN Metal-Oxide-Semiconductor High Electron Mobility Transistor (MOSHEMT) biosensor incorporating an embedded nanocavity positioned adjacent to the drain, designed for sensing biomolecules that are either neutral or carry a net charge. Device behaviour is simulated using the Silvaco ATLAS framework with advanced physical models to accurately capture electrostatic and carrier transport phenomena. Neutral biomolecules are modelled through their dielectric permittivity, whereas charged biomolecules are represented by both their dielectric constant a
- Europe PMC · Published · First archived
The role of social white matter tracts in susceptibility to phishing in aging. ↗
Vulnerability to fraud and financial exploitation among older adults is an increasing public health concern. Growing evidence supports that cognitive and socioemotional changes with age contribute to greater exploitation risk among older adults, while the neural mechanisms of heightened susceptibility to deception in aging are not well understood. Of note, white matter tracts are particularly impacted in aging and are likely implicated in deception detection. This study, for the first time, examined the extent to which age-related differences in white matter pathways subserving social cognitio
- Europe PMC · Published · First archived
Capsicum annuum L. oleoresin attenuates complete Freund's adjuvant-induced arthritis through modulation of COX-2-associated inflammation and oxidative stress. ↗
Rheumatoid arthritis is a chronic autoimmune disorder involving inflammatory cytokine dysregulation, oxidative stress and progressive joint damage. This study evaluated the anti-arthritic activity of Capsicum annuum L. oleoresin using in vitro, in vivo and in silico approaches. Oleoresins were prepared by Soxhlet and maceration extraction with solvents of different polarities and characterized by FTIR and GC-MS. Ethanolic Soxhlet extraction produced the highest yield (29.68%) and strongest antioxidant activity, showing 76.22 ± 0.58% DPPH, 63.77 ± 0.29% H2O2, 74.09 ± 0.21% ABTS and 65.49 ± 0.10
- Europe PMC · Published · First archived
Urban Road Dust as a Microbial Hotspot: Spatial Variation of Bacterial Communities and Metal Associations in the Philippines. ↗
Urban road dust is a reservoir and transport medium for diverse microorganisms, yet its bacterial communities in tropical environments remain poorly understood. This study examined the spatial variation of road dust bacterial communities across three Philippine metropolitan areas: Metro Manila, Metro Cebu, and Metro Cagayan de Oro, spanning the country's three principal island groups. Dust from nine sites was analyzed using 16 S rRNA gene metabarcoding (V3-V4), with community composition, diversity, predicted functional potential (PICRUSt2), and metal associations evaluated; contamination was
- Europe PMC · Published · First archived
Emerging Corynebacterium diphtheriae ST-212 cluster with truncated tox gene linked by possible sexual transmission. ↗
Despite low incidence, Corynebacterium (C.) diphtheriae remains a pathogen of concern, particularly due to emerging clusters of toxigenic and non-toxigenic strains causing respiratory, wound or invasive infections, and even recent fatal cases. This study aimed to investigate genetic relationships, characteristics, and epidemiological links among recent C. diphtheriae isolates of sequence type (ST)-212 from Germany, Austria, and Switzerland, focusing on their tox gene status and transmission routes. Four isolates collected 2022-2024 underwent whole genome sequencing (WGS). Analyses included mul
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Check each original source for its methods, release status, limitations, and supporting data. A repository announcement, a preprint, and a published study provide different kinds of evidence. SYMTRI’s subject classification helps discovery; it does not independently validate the source’s claims.
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