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Earlier sources: Science
Science investigates the natural world through observation, experiments, and mathematical models. Explore papers and developments in biology, medicine, materials, neuroscience, physics, climate, and mathematics; a reported finding is not necessarily established consensus.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗1472 classified signals in the fourteen-day window. Recent momentum: steady. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- Europe PMC · Published · First archived
LIPC-E97G Gain-of-function variant potentiates the hypocholesterolemic and anti-atherogenic effects of evinacumab in Ldlr-/- mice ↗
Introduction: Cardiovascular disease is the leading cause of death worldwide (Dagenais et al. 2020), and its main risk factor is LDL-C (Hagenbeek et al. 2020). Only a few genes are associated with LDL-C concentrations, and only 2 genes, ANGPTL3 (Musunuru et al. 2010) and LIPC, are associated with familial combined hypocholesterolemia. Our team recently identified the second genetic cause associated with familial combined hypocholesterolemia, a gain-of-function mutant of the LIPC gene encoding hepatic lipase (HL), LIPC-E97G (Dijk et al. 2022). Although the mode of action of this variant remains
- Europe PMC · Published · First archived
Leveraging Shared Genetic Architecture Between Psychiatric and Other Medical Disorders Increases Power and Reveals Novel Psychiatric Risk Loci ↗
Psychiatric disorders frequently co-occur with a broad range of non-psychiatric conditions, suggesting shared biological mechanisms that transcend traditional diagnostic boundaries. Although recent studies have demonstrated substantial genetic overlap between psychiatric and other medical disorders, the genomic architecture underlying these relationships and the extent to which shared genetic liability can be leveraged for psychiatric gene discovery remain incompletely understood. Here, we systematically investigated the shared genetic architecture between eleven major psychiatric disorders an
- Europe PMC · Published · First archived
Take it personally: Promoting a personalised neuroscience informed approach to cognitive rehabilitation following psychopathology. ↗
People suffering from schizophrenia, depression and other severe mental illnesses often suffer from cognitive problems. In most people, these problems persists after the major symptomatic episode is over, and in some cases cognitive problems also preceded an episode. Unfortunately, even after symptomatic remission, full recovery of cognitive functions often does not occur, thereby severely and enduringly impeding daily life functioning. Although it’s recognized in the field of psychiatry and psychology that these cognitive problems persist, there is little mechanistic understanding of how thes
- Europe PMC · Published · First archived
The Effect of a Neuroeducation Program on L2 Automatization and Acquisition for Intermediate Young Adult Learners ↗
Abstract Almost without exception, adult second language (L2) learners fail to acquire an L2 to a comparable level of proficiency as their first language (L1). In part, traditional teaching approaches fail to address this issue or adapt to the equipotential brain. In light of this, this research attempted to explore language acquisition from a neuroeducation perspective. Accordingly, a neuroeducation program was developed which draws on concepts from neuroscience. The neuroeducation program was developed based on the LIRRA neuroeducational model which was proposed to automatize L2 and improve
- Europe PMC · Published · First archived
Cis-meQTL mapping reveals genetic architecture of DNA methylation in a giga-genome species ↗
Abstract Whether variation in plant DNA methylation is mostly under genetic control (and therefore heritable and accessible to selection) or driven by environmental cues remains unsolved, which has consequences for epigenetic breeding and for understanding heritable phenotypic plasticity. We addressed this question by running cis-methylation quantitative trait locus (cis-meQTL) mapping across all three methylation contexts (CpG, CHG, and CHH) in 602 Norway spruce ( Picea abies (L.) H. Karst.) seedlings, pairing exome capture sequencing and targeted enzymatic methylation sequencing across the s
- Europe PMC · Published · First archived
Multi-Omics Integration Across Regulatory Layers Reveals Candidate Drivers of Severe COVID-19 Immunopathology ↗
The clinical heterogeneity of COVID-19 is well known but its determinants are not fully understood, and the regulatory mechanisms connecting host genetic risk to the transcriptional signature of severe disease have seldom been addressed in one framework. Peripheral blood mononuclear cells (PBMCs) provide a convenient way to measure the systemic immune dysregulation seen in severe SARS-CoV-2 infection, yet most transcriptomic studies of this cell type stop at describing differential expression, rather than asking what drives it. In this study, a focused discovery cohort of 10 PBMC transcriptome
- Europe PMC · Published · First archived
Genotype C Mumps Virus Associated with the 2026 Outbreak: The Johns Hopkins Health System ↗
Background: Mumps virus remains an important cause of outbreaks in vaccinated populations despite widespread use of measles–mumps–rubella/varicella (MMR/V) vaccines. Early in 2026, an increase in mumps cases was identified within the Johns Hopkins Health System (JHHS), coinciding with statewide reported cases in the state of Maryland. Methods: Molecular testing was implemented for case confirmation, and positive specimens underwent whole-genome sequencing. Epidemiologic and clinical data were abstracted from medical records. Phylogenetic analysis was performed using complete and partial genome
- Europe PMC · Published · First archived
Childhood Attention-Deficit/Hyperactivity Disorder and the Subsequent Emergence of Psychiatric Disorders: A Narrative Review of the Evidence for Independence from Childhood Comorbidity, with Clinical Implications ↗
Objective: To determine whether childhood attention-deficit/hyperactivity disorder (ADHD) predicts the subsequent emergence of psychiatric disorders independent of disorders already present in childhood, and to translate the evidence into clinical recommendations. Method: Narrative review of meta-analyses, systematic reviews, prospective longitudinal cohorts, population-based register studies, and clinical practice guidelines identified through searches of PubMed/MEDLINE, Embase, PsycINFO, and Web of Science, prioritizing studies with substantial citation impact. Results: Childhood ADHD robust
- Europe PMC · Published · First archived
Bacterial Cheminformatics: Large Language Models and Challenges in Bacterial Chemspace ↗
The escalating global crisis of antimicrobial resistance (AMR), often characterized as a "silent pandemic," necessitates a paradigm shift in antibiotic discovery. Traditional cheminformatics pipelines, reliant on hand-crafted molecular descriptors and low-throughput screening, are increasingly insufficient to address the evolving threats of multidrug-resistant pathogens. This Opinion article explores the transformative integration of Large Language Models (LLMs) and foundational Transformer architectures into bacterial cheminformatics. We argue that the field is transitioning from simple discr
- Europe PMC · Published · First archived
Prompt-as-a-Protocol with Agentic Research Automation: A Validated Methodology for AI-Native Biomedical Data Science Producing Peer-Reviewed Findings Across Genomics and Biosensor Domains ↗
Recent advances in large language model (LLM)-driven agentic systems have demonstrated capabilities for automating biomedical data analysis workflows. However, existing systems are predominantly validated on synthetic benchmarks or retrospective tasks, without demonstrated production of novel, peer-reviewed biological findings. Here we describe Prompt-as-a-Protocol (PaaP), a methodology that converts natural-language research questions into structured, executable analytical protocols, coupled with an agentic Generative Research Automation (GRA) layer that executes these protocols with integrat
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How to assess evidence about Science
Check each original source for its methods, release status, limitations, and supporting data. A repository announcement, a preprint, and a published study provide different kinds of evidence. SYMTRI’s subject classification helps discovery; it does not independently validate the source’s claims.
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