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Earlier sources: Science
Science investigates the natural world through observation, experiments, and mathematical models. Explore papers and developments in biology, medicine, materials, neuroscience, physics, climate, and mathematics; a reported finding is not necessarily established consensus.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗1473 classified signals in the fourteen-day window. Recent momentum: steady. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- Europe PMC · Published · First archived
A Genetic Method for Distinguishing Cryptic Pocillopora Species in French Polynesia Without Sequencing. ↗
Pocillopora is a widespread, dominant reef-building coral genus in the Indo-Pacific; many species within this group exhibit high morphological similarity and plasticity. Given this, genetic tools are needed to robustly identify Pocillopora individuals to the species level. Quick and accurate identification approaches for Pocillopora species are critical to estimating biodiversity patterns under current and future environmental challenges. In recent years, the mitochondrial open reading frame (mtORF) and a histone region (PocHistone) have been validated using genome-wide data to become the most
- Europe PMC · Published · First archived
Phylogenomics Clarifies Plastome Reduction and Phylogenetic Relationships in Monotropoideae. ↗
Plastome evolution and biogeographic history remain poorly understood in mycoheterotrophic lineages. Here, we sequenced and assembled the complete plastome of Monotropa callistoma (Ericaceae), a fully mycoheterotrophic species, and compared it with other mycoheterotrophic plastomes. The M. callistoma plastome is 29,784 bp long, lacks the canonical quadripartite structure, and contains 40 genes, representing an intermediate level of reduction within Monotropoideae. Comparative analyses revealed extreme contraction in some lineages, including Sciaphila (12.8-21.5 kb), and a weak positive correla
- Europe PMC · Published · First archived
A Health-Protective Screening Threshold for Personal Care Products: Metabolomic and Endocrine Mechanisms of Adolescent Reproductive Toxicity in Zebrafish. ↗
Adolescents are uniquely vulnerable to endocrine-disrupting chemicals (EDCs) due to the critical maturation of the hypothalamic-pituitary-gonadal (HPG) axis, yet current safety assessments overlook whole-formulation risks during this developmental window. Using an adolescent zebrafish model, we established a biologically anchored screening threshold and elucidated the molecular mechanisms of formulation toxicity. Direct exposure to personal care products at unadjusted Scientific Committee on Consumer Safety (SCCS)-derived concentrations caused severe systemic overload (F1 survival ≤ 16.87%). H
- Europe PMC · Published · First archived
Inhibition of the NR4A1-mediated cell cycle checkpoint enhances hyperplastic adipogenesis and glucose homeostasis in obesity. ↗
The nuclear receptor NR4A1 is a critical node in transcriptional circuits for metabolic adaptation, yet its role in adipocyte progenitor (AP) fate and proliferation is unclear. We sought to define how NR4A1 governs early adipogenesis and adipose tissue plasticity. Doxycycline-inducible NR4A1-overexpressing and NR4A1-deficient 3T3-L1 models were used to assess lipid accumulation, mitotic clonal expansion (MCE), and cell-cycle dynamics. Multiomics integration (RNA-seq and chromatin assays) identified NR4A1 targets. The functionality of two lead candidates, ANLN and CDC20, was tested by genetic k
- Europe PMC · Published · First archived
Primary Culture and Characterization of Postnatal Retinal Precursor Cells and Their Potential for Repair of the Damaged Ganglion Layer. ↗
Retinal precursor cells (RPCs) derived from embryonic, mesenchymal, induced pluripotent, and neonatal sources have demonstrated significant potential in cell replacement therapies for retinal degeneration. Early postnatal RPCs (PND0-PND8) can integrate into the adult diseased retina; however, their limited survival reduces long-term therapeutic efficacy. In contrast, RPCs from later neonatal stages (>PND15), being more lineage-committed, may yield improved regenerative outcomes, particularly for Müller glia and photoreceptors. In this study, we evaluated RPCs isolated from PND12-PND15 Wistar r
- Europe PMC · Published · First archived
BpSRK1-mediated phosphorylation of BpERF3 relieves HDA6-dependent chromatin repression to enhance drought tolerance in birch. ↗
Drought tolerance in plants requires rapid conversion of water-deficit signals into protective transcriptional and epigenetic programs. Although ERF transcription factors (TFs) are central regulators of stress-responsive gene expression, how drought-induced kinase signaling is coupled to chromatin regulation and antioxidant gene activation remains unclear. Here, we identify the ERF TF BpERF3 as a phosphorylation-dependent regulator of drought tolerance in birch (Betula platyphylla). Using transgenic and CRISPR-Cas9 mutant lines, protein interaction assays, immunoaffinity fluorescent electropho
- Europe PMC · Published · First archived
A beta way: A tutorial on Bayesian beta regression for psychological research. ↗
Rates, percentages, and proportions are common outcomes in psychology and the social sciences. These outcomes are often analyzed using models that assume normality, but this practice overlooks important features of the data, such as their natural bounds at 0 and 1. As a result, estimates can become distorted. In contrast, treating such outcomes as beta-distributed respects these limits and can yield more accurate estimates. Despite these advantages, the use of beta models in applied research remains limited. Our goal is to provide researchers with practical guidance for adopting beta regressio
- Europe PMC · Published · First archived
A dual-action bacteriophage protein Ped1 degrades DNA and blocks replication in Pseudomonas aeruginosa. ↗
To fully harness phage therapy against escalating antimicrobial resistance, it is imperative to elucidate the fundamental mechanisms by which viruses systematically dismantle host physiology. In this study, we identify Ped1, a protein from Pseudomonas aeruginosa phage PaoP5, which suppresses bacterial growth through two mechanisms: degradation of genomic DNA and direct inhibition of the replication machinery. Our 2.3-Å crystal structure and biochemical profiling reveal that Ped1 adopts a previously uncharacterized α/β-nuclease architecture, enabling the efficient cleavage of both double-strand
- Europe PMC · Published · First archived
Single-allele nanoscale mapping of regulatory variants. ↗
Millions of genetic variants are linked to human disease but identifying underlying mechanisms is challenging because most variants are noncausal and lie within the noncoding genome. We developed a Micro Capture-C variant-to-function platform (MCCv) based on analysis of single-allele chromatin structure. This can identify changes in nanoscale chromatin architecture and link variants in cis-regulatory elements to target genes. Furthermore, MCCv can phase other heterozygous variants within a locus to link regulatory variants to allelically imbalanced gene expression and directly read out variant
- Europe PMC · Published · First archived
Single-molecule chromatin tracing reveals a diversity of megabase heterochromatin domains. ↗
Chromosomes fold into distinct domains that regulate transcription, replication and repair. In addition to well-characterized topologically associating domains (TADs) and compartments, the diversity of heterochromatin domains remains poorly defined at the sequence level. Here, using single-molecule tracing of nascent heterochromatin in Caenorhabditis elegans, we identify three classes of megabase-scale domains: (1) sharp-boundary, condensin I-dependent TAD-like domains (TADLs), which arise before zygotic genome activation; (2) similarly sized, but condensin-independent, elegans condensin-indep
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How to assess evidence about Science
Check each original source for its methods, release status, limitations, and supporting data. A repository announcement, a preprint, and a published study provide different kinds of evidence. SYMTRI’s subject classification helps discovery; it does not independently validate the source’s claims.
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