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Earlier sources: Science
Science investigates the natural world through observation, experiments, and mathematical models. Explore papers and developments in biology, medicine, materials, neuroscience, physics, climate, and mathematics; a reported finding is not necessarily established consensus.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗1540 classified signals in the fourteen-day window. Recent momentum: steady. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- Europe PMC · Published · First archived
Prolonged low-dose intravenous thrombolysis in early recurrent stroke. ↗
Introduction Treatment of acute ischemic stroke follows well-established guidelines and standards of care. However, the optimal management of ultra-early stroke recurrence remains unclear. We present outcomes of prolonged low-dose intravenous thrombolysis used as rescue therapy in this setting. Material and methods This multicenter retrospective study included consecutive patients who received prolonged low-dose intravenous thrombolysis (20 mg of alteplase administered continuously over 10 hours) for early recurrent ischemic stroke. Clinical status was assessed using the National Institutes of
- Europe PMC · Published · First archived
Demographic, history, university and lifestyle factors associated with university student mental health: cross-sectional analysis across five UK universities. ↗
Background The whole-university approach to mental health emphasises that well-being should be a strategic priority across all aspects of higher education. However, there is limited evidence on which aspects of university life institutions should target to maximise well-being. Aim To identify factors associated with student mental health and well-being and provide an evidence base for developing initiatives that protect and promote this. Methods The Nurture-U survey was conducted across five universities in the UK from 2022 to 2024. This cross-sectional sample of the survey data assessed stude
- Europe PMC · Published · First archived
Accurate m 6 A modification forcefield for conformation sampling of RNA. ↗
N 6 -Methyladenosine (m 6 A) is a prevalent RNA modification that regulates RNA structure, metabolism, and molecular recognition. Atomistic interpretation of these effects requires force fields that describe the context-dependent balance between paired and unpaired m 6 A. Here, we developed MODM6A, a localized m 6 A-U interaction correction derived from rigid interaction-energy scans in which both the quantum-mechanical (QM) and molecular-mechanical (MM) reference energies included implicit aqueous solvation. The implicit-water QM profile had a minimum of -9.58 kcal mol -1 at 0.190 nm, whereas
- Europe PMC · Published · First archived
Targeting the DNHD1‑HDAC6 axis inactivates prostate cancer cell aggressiveness in vitro , suggesting potential therapeutic vulnerability. ↗
Prostate cancer progression toward an aggressive, therapy‑resistant disease state remains a major clinical challenge, indicating a need to identify novel molecular drivers of such progression and actionable therapeutic targets. The present study analyzed the role of dynein heavy chain domain 1 ( DNHD1 ), a previously uncharacterized regulator of malignancy, in prostate cancer. Integrative transcriptomic analyses across The Cancer Genome Atlas and independent clinical cohorts revealed that DNHD1 is markedly upregulated in advanced‑stage prostate cancer and positively correlated with increasing
- Europe PMC · Published · First archived
Spatial multi‑omics identifies an SPP1+ macrophage‑driven anti‑apoptotic niche in osteoarthritis synovium via the SPP1‑CD44 axis. ↗
Osteoarthritis (OA) progression is driven by chronic synovitis. However, the spatially organized macrophage subsets that sustain unresolved inflammation through evasion of apoptosis remain poorly characterized. The present study investigated the functional subsets and spatial niches of synovial macrophages that regulate apoptotic pathways in OA pathogenesis. Spatial transcriptomics, single‑cell RNA sequencing and in vitro apoptotic models were integrated to characterize macrophage interactions in the OA synovium. The anti‑apoptotic role of SPP1 + macrophages was evaluated using adeno‑associate
- Europe PMC · Published · First archived
Multi-omics Mendelian randomisation reveals distinct molecular drivers of pathological myopia complications vs simple myopia. ↗
Background Pathological myopia complications are leading causes of irreversible blindness, yet the molecular mechanisms distinguishing them from simple myopia remain poorly understood. We aimed to compare the molecular profiles associated with pathological myopia complications and simple myopia using a multi-omics Mendelian randomisation (MR) framework. Methods Using circulating protein quantitative trait loci data from the INTERVAL study, plasma metabolite genome-wide association study (GWAS) data from the Nightingale Health - UK Biobank initiative and outcome GWAS data for four complication
- Europe PMC · Published · First archived
[Corrigendum] Alteration of the Wnt/GSK3β/β‑catenin signalling pathway by rapamycin ameliorates pathology in an Alzheimer's disease model. ↗
Following the publication of the above article, a concerned author drew to the authors' attention that they had apparently used an inappropriate antibody in their study: In the Materials and methods section, the authors had reported the use of Abcam's recombinant antibody against plant homeodomain (PHD) finger protein 1 (a.k.a. PHF1; cat. no. ab184951) to probe for the unrelated protein, tau paired helical filaments (PHFs). Based on their search of previous literature, the authors acknowledged that they had made a methodological error in selecting the incorrect antibody; therefore, the western
- Europe PMC · Published · First archived
Protein turnover in juvenile tropical rock lobster (Panulirus ornatus) and its implications for growth bioenergetics. ↗
Protein turnover (the continuous synthesis and degradation of the proteome) is energetically expensive and strongly correlates with growth rate in ectotherms. However, in crustaceans our understanding of whole-body protein turnover is limited. This restricts our ability to accurately determine dietary protein and energy utilisation efficiency, which are critical for optimising aquaculture nutrition. This study investigated how two isoenergetic feeds containing 42% (CP42) or 64% (CP64) crude protein impact post-prandial metabolism, nitrogen flux and protein turnover in tropical rock lobster (Pa
- Europe PMC · Published · First archived
Distinct roles for TANGO1S domains in maintaining ER-Golgi architecture. ↗
The endoplasmic reticulum (ER)-Golgi interface is a dynamic trafficking hub maintained in part by TANGO1, a scaffolding protein that coordinates proteins and membranes at ER exit sites (ERES). TANGO1 has two isoforms: TANGO1L, which has a lumenal SH3 domain, and TANGO1S, which lacks this domain but retains the transmembrane and cytoplasmic coiled-coil (CC), TEER, and PRD domains common to both forms. We showed previously that loss of both isoforms disrupts ER-Golgi organization more severely than TANGO1L loss alone, indicating TANGO1S is functional and can compensate. Here we dissect the role
- Europe PMC · Published · First archived
International Modified Delphi Consensus on Assessment and Management of Covert Brain Infarction. ↗
BackgroundCovert brain infarction (CBI) is a frequent incidental neuroradiological finding increasingly recognized as clinically relevant due to its association with stroke, cognitive decline, and other adverse outcomes. However, substantial uncertainty remains regarding its optimal assessment and management, and existing guidelines provide limited and heterogeneous recommendations. We aimed to develop an international expert consensus on the evaluation and management of CBI using a modified Delphi methodology.MethodsA modified Delphi process was conducted with an international, multidisciplin
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Check each original source for its methods, release status, limitations, and supporting data. A repository announcement, a preprint, and a published study provide different kinds of evidence. SYMTRI’s subject classification helps discovery; it does not independently validate the source’s claims.
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