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Earlier sources: Science
Science investigates the natural world through observation, experiments, and mathematical models. Explore papers and developments in biology, medicine, materials, neuroscience, physics, climate, and mathematics; a reported finding is not necessarily established consensus.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗1549 classified signals in the fourteen-day window. Recent momentum: steady. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- OpenAlex · Published · First archived
A Randomized Clinical Trial of a Standardized Pumpkin-Seed-Derived Peptide Extract: Body Composition Outcomes and Exploratory Analysis by Baseline Adiposity in Overweight Adults ↗
This 12-week, randomized, double-blind, placebo-controlled trial enrolled 50 overweight adults who received either a standardized pumpkin-seed-derived preparation (IRK-19®, 600 mg/day) or placebo. The clinical preparation contained 66.2% crude protein; components with apparent molecular weights ≤6.29 kDa accounted for 23.6% of the total SEC-UV chromatographic area, and the combined HPLC-measured content of six selected peptide markers was 2.79% (w/w). Among the 48 participants with evaluable DXA data at Week 12, between-group comparisons of body weight, BMI, and adiposity-related outcomes did…
- OpenAlex · Published · First archived
A Data-Centric Diagnostic Framework for Experimental Design and Mechanistic Modeling: Application to mRNA Production ↗
Abstract In this study, we present a data-centric framework for the integrated investigation of experimental behavior and mechanistic model performance in complex biochemical systems. The framework is demonstrated on the in vitro transcription (IVT) reaction for mRNA production. Rather than analyzing experimental data and mechanistic models independently, the framework links experimental-response surrogate modeling, a surrogate model of error characterizing model–experiment discrepancy, and mechanistic parameter sensitivity within a unified workflow. Gaussian Process Regression (GPR) and Globa…
- OpenAlex · Published · First archived
Emerin modulation impacts viability, proliferation, migration, and DNA repair signaling in cisplatin-treated glioblastoma cells ↗
Abstract Emerin (EMD), an inner nuclear membrane protein essential for nuclear architecture integrity, gene expression, cellular signaling, and chromatin stability, interacts with the LINC complex and participates in cytoskeleton-nucleoskeleton communication by binding to nuclear actin filaments. EMD is implicated in migration, invasion, and metastasis in some tumors, but its role in glioblastoma (GBM) remains unclear. This study evaluated the effects of EMD knockdown and overexpression in GBM cell lines following genotoxic treatment with cisplatin. In both wild-type p53 (U87-MG) and mutant p5…
- OpenAlex · Published · First archived
Bioprocess Intensification Using Perfusion Culture for Recombinant Protein Production from Lactococcus lactis ↗
Secretion of recombinant proteins from microbial cell factories is a promising strategy for recombinant protein biomanufacturing as it simplifies downstream processing. In this study, we sought to intensify the Lactococcus lactis high-cell-density culture, using basic fibroblast growth factor 2 (FGF2) as a model recombinant protein. We implemented a perfusion strategy using tangential flow filtration for cell retention, allowing the continuous removal of inhibitory metabolites while replenishing fresh nutrients. When conventional 2 × GM17 medium was used, the approach outperformed batch cultiv…
- OpenAlex · Published · First archived
Chromosome-scale assembly of yeast genomes using enzyme-free, dense optical genome mapping ↗
Large repetitive elements and complex chromosomal organization continue to challenge accurate assembly of eukaryotic genomes. Optical genome mapping (OGM) provides long-range genomic information by imaging individual DNA molecules. While most OGM protocols rely on sparse enzymatic labeling that restricts resolution in poorly labeled or structurally complex regions, dense labeling strategies generate continuous fluorescence intensity profiles that offer a complementary representation of genome structure. Here we extend our Dense Optical Genome Mapping Assembly (DOGMA) pipeline, previously used…
- OpenAlex · Published · First archived
Physics-informed neural operators for the in situ characterization of locally reacting sound absorbers ↗
Accurate knowledge of acoustic surface admittance or impedance is essential for reliable wave-based simulations, yet its in situ estimation remains challenging due to noise, model inaccuracies, and restrictive assumptions of conventional methods. This work presents a physics-informed neural operator approach for estimating frequency-dependent surface admittance directly from near-field measurements of sound pressure and particle velocity. A deep operator network is employed to learn the mapping from measurement data, spatial coordinates, and frequency to acoustic field quantities, while simult…
- OpenAlex · Published · First archived
Combined Effects of ATRA and ASA on HeLa Cell Viability, MAPK/AKT-Related Protein Abundance, and Intracellular VEGF: An Integrated In Vitro and In Silico Study ↗
Background/Objectives: All-trans retinoic acid (ATRA) and acetylsalicylic acid (ASA; aspirin) have been reported to influence cancer-associated signaling through distinct molecular mechanisms, but their combined effects on cervical cancer cells remain incompletely characterized. This study evaluated the individual and combined effects of ATRA and ASA on HeLa human cervical cancer cells and used computational analyses as supportive, hypothesis-generating mechanistic contextualization. Methods: Cell viability was assessed by MTT assay after treatment with increasing concentrations of ATRA and AS…
- OpenAlex · Published · First archived
Regulation of cellular proteostasis via mitochondrial protein import ↗
Mitochondria are the powerhouse of the cell, playing vital roles in energy production and metabolism. Most mitochondrial proteins are encoded in the nuclear DNA and must be synthesized in the cytosol before being transported into the appropriate mitochondrial compartments. Mitochondrial protein import is not only essential for mitochondrial biogenesis but also a crucial regulatory step in mitochondrial proteostasis surveillance and stress response. Additionally, defects in mitochondrial protein import lead to mislocalization of precursor proteins to the cytosol, disrupting cytosolic proteostas…
- OpenAlex · Published · First archived
Acanthamoeba castellanii genome reannotation and multi-omic encystation profiling reveals cyst wall proteins and carbohydrate-active enzymes ↗
Acanthamoeba castellanii is both a key evolutionary outgroup to humans and a free-living amoeba that causes eye infections. During infection, trophozoites damage the cornea and convert to drug-resistant cysts. Systematic characterization of encystation pathways has been hindered by poor genome annotation. We used long-read RNA sequencing across an encystation time course to improve annotation accuracy from 52% to 98%. Orthogroup analyses showed one-third of Acanthamoeba genes are absent in humans and so may be drug targets. We identified 20 cyst wall protein families. Multiple carbohydrate-act…
- OpenAlex · Published · First archived
Quantum Autoencoders for Network Anomaly Detection: A Comparative Benchmark with Classical Methods ↗
The practical value of quantum machine learning for network anomaly detection remains unclear under controlled and comparable benchmarking conditions. This study evaluates a trash-qubit-based Quantum Autoencoder (QAE) against seven classical anomaly-detection methods on UNSW-NB15 using shared data partitions, preprocessing steps, model selection procedures, and threshold calibration protocols. The experimental design included five independent seeds, three training set sizes, two feature budgets, and 12 QAE architectures, together with low-FPR analysis, finite-shot and synthetic-noise evaluatio…
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How to assess evidence about Science
Check each original source for its methods, release status, limitations, and supporting data. A repository announcement, a preprint, and a published study provide different kinds of evidence. SYMTRI’s subject classification helps discovery; it does not independently validate the source’s claims.
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