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Earlier sources: Science
Science investigates the natural world through observation, experiments, and mathematical models. Explore papers and developments in biology, medicine, materials, neuroscience, physics, climate, and mathematics; a reported finding is not necessarily established consensus.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗1561 classified signals in the fourteen-day window. Recent momentum: steady. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- OpenAlex · Published · First archived
Genetic syndromes and metabolic diseases: weighting their clinical convergence in the pediatric setting ↗
Abstract Background Neurodevelopmental disorders, hypotonia, microcephaly or macrocephaly, poor growth and distinctive facial traits are some of the most common reasons to refer a child to an expert consultant. But which expert? A priori response might not be always predictable. Clinical experience teaches that it is not unusual to come across a metabolic diagnosis in a patient suspected of a genetic condition and vice versa. Still, although phenotypically convergent, genetic and metabolic disorders strongly diverge on therapeutic availability. In such an entangled scenario, new sequencing tec…
- OpenAlex · Published · First archived
Ubiquitin chain editing promotes p97/VCP-dependent removal of RPA from DNA ↗
DNA repair requires dynamic control of proteins on single-stranded DNA (ssDNA), yet how ubiquitin signaling regulates ssDNA-bound factors remains poorly understood. Here, we identify in human cells a ubiquitin chain-editing mechanism that promotes extraction of replication protein A (RPA) from ssDNA. We show that RPA stimulates the deubiquitinase ZUP1 and enhances its activity toward K63 linkages within ubiquitin chains. In response to DNA damage, RPA is modified with branched K48-K63 ubiquitin chains. ZUP1 selectively removes K63 linkages from these chains, remodeling the ubiquitin signal on…
- OpenAlex · Published · First archived
SOX17 in Gynecologic Tumors: Biology and Diagnostic Applications ↗
SOX17 is a developmental transcription factor that regulates endoderm formation, vascular development, germ cell specification, and tissue differentiation. Recent studies have identified SOX17 as a highly informative immunohistochemical marker and lineage-associated regulator in gynecologic pathology. This review summarizes the physiological functions of SOX17, its expression in normal and neoplastic tissues, and its expanding diagnostic and translational applications. SOX17 demonstrates high sensitivity for most ovarian and endometrial epithelial carcinomas while exhibiting substantially grea…
- OpenAlex · Published · First archived
Dosimetric analysis of CT/MRI-based target delineation differences in radiotherapy for brain metastases close to the skull ↗
To quantify the dosimetric differences associated with CT/MRI-based target delineation in radiotherapy for brain metastases close to the skull (BMCS), and to provide dosimetric evidence for target delineation and treatment-plan evaluation. This retrospective study included 245 BMCS lesions from 132 patients who underwent radiotherapy, including 88 lesions treated with whole-brain radiation therapy (WBRT), 67 treated with local radiation therapy (LRT), and 90 treated with simultaneous integrated boost (SIB). The gross tumor volumes (GTVs) from the original clinical treatment plans, which had be…
- OpenAlex · Published · First archived
From molecular signal to clinical solution: extracellular vesicles in precision medicine for neurodegenerative diseases ↗
Neurodegenerative diseases continue to elude effective treatment because there are no tools available for detecting subclinical pathology, and therefore providing CNS-targeted interventions, prior to incompletely reversible neuronal loss. Extracellular vesicles (EVs), nanosized, membrane-delimited particles released by all cell types in the CNS, have emerged as highly promising therapeutic candidates to target the existing challenges in parallel. Their cell-type-specific molecular cargo is a faithful replicator of disease state and can be monitored at an early stage, longitudinally through tim…
- OpenAlex · Published · First archived
The Oral–Gut Microbiome Axis: Microbial Transit, Ectopic Colonization, Systemic Associations, Salivaomics, and Clinical Control Points ↗
The oral cavity is a continuous microbial source for the gastrointestinal tract. Adults swallow approximately 0.5–1.5 L of saliva each day, carrying a large and variable bacterial load. Gastric acidity removes most ingested organisms, but survival increases with food buffering, acid tolerance, mucin or biofilm protection, and proton-pump inhibitor use. Oral taxa are therefore repeatedly detected in stool, intestinal mucosa, and diseased tissues. The strongest mechanistic evidence concerns Fusobacterium nucleatum in colorectal cancer and Porphyromonas gingivalis in inflammatory and metabolic pa…
- OpenAlex · Published · First archived
Genome-wide discovery of cis-regulatory elements in a large genome ↗
Identifying cis- regulatory elements typically relies on trial and error to test the activity of DNA fragments using reporter constructs. This approach is particularly challenging in large eukaryotic genomes, where cis- regulatory elements can be dispersed over long distances, separated by large stretches of non-functional DNA. Here, we generate two types of resources that can be used to narrow the search for such elements in the 3.6 Gbp genome of Parhyale hawaiensis . First, we use bulk ATAC-seq to uncover genome-wide patterns of chromatin accessibility in Parhyale embryonic and adult tissues…
- OpenAlex · Published · First archived
Global research trends in clinical studies of ginseng: a bibliometric and text-as-data analysis ↗
Clinical research on ginseng has expanded considerably, yet most bibliometric syntheses still rely on publication counts and co-occurrence maps. We mapped research on Panax ginseng and demonstrated a text-as-data and network pipeline. English-language publications indexed in the Science Citation Index Expanded (2004–2026) were retrieved using ginseng- and clinical-study-related terms and screened by two reviewers. CiteSpace and R-based clustering and citation-burst analyses were supplemented with topic modelling, word embeddings, a cross-validated study-type classifier, social-network analysis…
- OpenAlex · Published · First archived
Integrative Machine Learning and Immunoinformatics-Guided Design and In Silico Validation of a Multiepitope DNA Vaccine Against Avian Metapneumovirus ↗
Avian metapneumovirus (aMPV) is an emerging viral pathogen causing many outbreaks in chickens all over the world. There are several subtypes of the MPV circulating in chickens in the US. The current circulating subtypes of the virus in the US chicken are A, B, and C. Despite the availability of some aMPV vaccines in the US, most of these vaccines are based on foreign strains, particularly European aMPV-A/B strains. Their protective efficacy against contemporary U.S. aMPV isolates has not been fully established. The main goal of this study is to integrate the most recent aMPV genome sequencing…
- OpenAlex · Published · First archived
Clinical and Microbiological Evaluation of EPEC and EAEC Detected by Multiplex Gastrointestinal PCR ↗
ABSTRACT Objective Enteropathogenic Escherichia coli (EPEC) and enteroaggregative Escherichia coli (EAEC) are frequently detected diarrheagenic E. coli pathotypes in multiplex gastrointestinal panels, but their clinical interpretation remains challenging, particularly in asymptomatic cases or with co-detected pathogens. This study determined the frequency of EPEC and EAEC in stool samples tested by multiplex gastrointestinal PCR and evaluated their relationship with recorded clinical presentations. Materials and Methods This retrospective observational study included stool samples submitted to…
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Check each original source for its methods, release status, limitations, and supporting data. A repository announcement, a preprint, and a published study provide different kinds of evidence. SYMTRI’s subject classification helps discovery; it does not independently validate the source’s claims.
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