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Earlier sources: Science
Science investigates the natural world through observation, experiments, and mathematical models. Explore papers and developments in biology, medicine, materials, neuroscience, physics, climate, and mathematics; a reported finding is not necessarily established consensus.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗1632 classified signals in the fourteen-day window. Recent momentum: steady. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- Europe PMC · Published · First archived
Gap-free near-T2T genome assembly of Digitalis lanata enables complete enzymatic production of digoxigenin ↗
Abstract Digoxigenin is the aglycone precursor of digoxin, a clinically important cardiotonic drug whose steroid scaffold is substituted with C12 β and C14 β hydroxyl groups and bears a characteristic C17 butenolide ring. Despite its longstanding clinical importance, the biosynthetic pathway leading to digoxigenin has remained largely unresolved. Here, we report the first gap-free near-telomere-to-telomere genome assembly of Digitalis lanata and construct an engineered enzymatic cascade for digoxigenin synthesis. Through comparative genomics, biosynthetic gene cluster analysis, transcriptome c
- Europe PMC · Published · First archived
Antagonistic DNA methylation dynamics at a single locus controls pollen tube guidance in Arabidopsis ↗
Abstract Active DNA demethylation mediated by DEMETER (DME) and REPRESSOR OF SILENCING1 (ROS1) is required for male fertility in Arabidopsis thaliana. Here we report that the loss of these demethylases results in persistent silencing of transposable element-like methylated (teM) genes in the pollen vegetative cell, leading to pollen tube growth and guidance defects, and reduced fertility. Consistently, we show that hypomethylation induced by a mutation of the chromatin remodeler DECREASE IN DNA METHYLATION 1 (DDM1) restores pollen fertility in demethylase mutants and rescues expression of the
- Europe PMC · Published · First archived
Dynamic RGB-depth phenotyping and association mapping reveal candidate loci for soybean plant height variation under contrasting light environments ↗
Abstract Background Plant height is a key agronomic trait in soybean and is strongly influenced by light availability. Accurate and scalable phenotyping under contrasting light environments remains a major constraint for dissecting plant-height variation and supporting downstream genetic analysis. Results Here, we evaluated 112 soybean accessions under normal-light (CK) and low-light (SL) conditions using a rail-based high-throughput phenotyping platform that integrated red-green-blue (RGB) imaging and depth sensing. A grayscale calibration and correction-coefficient strategy was developed to
- Europe PMC · Published · First archived
Genomic Connectivity and Adaptive Gene Flow of Anopheles gambiae s. s. Across East and Central Africa ↗
Abstract Population connectivity influences the adaptive capacity of disease vectors by mediating the spread of insecticide resistance alleles. High gene flow poses challenges for tailored intervention strategies targeting localised populations, but connectivity is often poorly characterised for particular geographical regions. This study uses whole-genome data to investigate the population connectivity of the Anopheles gambiae malaria vector across East-Central Africa, including understudied populations from Ethiopia. We also investigated adaptive gene flow using Diplotype clustering at known
- Europe PMC · Published · First archived
Haplotype-resolved PacBio HiFi genome assemblies of the olive cultivar ‘Picual’ ↗
Abstract We present a chromosome level genome assembly for Olea europaea L. cultivar ‘Picual’, as well as the two corresponding haplotypes, obtained using PacBio HiFi sequencing. Four SMRT Cells were used for sequencing, resulting in a 35.5× sequencing depth. The consensus genome displayed a total assembly length of 1.24 Gbp, with an N50 value of 45.8 Mbp, an L50 of 11, and a largest scaffold of 91.4 Mbp. BUSCO (v5.8.2) analysis show a good conserved gene completeness (97.9%), with only 1.0% missing and 1.1% fragmented genes out of the 2,326 conserved eudicot genes analyzed. Regarding the hapl
- Europe PMC · Published · First archived
Polygenic Architecture and Molecular Pathways Underlying Methadone Treatment Response in Opioid Use Disorder: Evidence from an Iranian Cohort ↗
Abstract Background Response to methadone maintenance therapy (MMT) varies widely, but its genetic basis remains poorly understood, particularly in non-European populations. We hypothesized that shared polygenic liability across psychiatric and substance use disorders contributes to earlier opioid use disorder (OUD) onset through specific pathways and predicts MMT response. Methods We analyzed 769 Iranian individuals with OUD receiving MMT. After quality control, subsets were used to: (i) test polygenic risk scores (PRS) for psychiatric, substance-use, and antidepressant response traits; and (
- Europe PMC · Published · First archived
Pangenome-resolved deconvolution of gut metatranscriptomes reveals species-specific microbial activity programs in Parkinson’s disease ↗
Abstract Gut microbiome alterations are associated with Parkinson’s disease (PD), yet their species-level functional consequences remain poorly understood. Here, we develop a pangenome-resolved framework integrating paired metagenomic and metatranscriptomic data to reconstruct species-level transcriptional profiles. Applied to two independent cohorts comprising 160 individuals and 7,548 profiles across 215 species, this approach revealed reduced genome-wide transcriptional breadth and increased inter-individual heterogeneity in PD. Genomic diversity and transcriptomic variation were significan
- Europe PMC · Published · First archived
Spatially variable barley root microbiomes do not imply weak host genetic control at field scale ↗
Abstract The plant microbiome has been proposed as ‘the second genome of the plant’, motivating interest in microbiome-assisted breeding. For microbiome-assisted breeding to become a reality, the plant genome must obviously have a role in regulation of the microbiome. However, agricultural fields are spatially heterogeneous, and it remains unclear how host genetics and soil heterogeneity jointly shape plant microbiomes under field conditions. Here, using 16S and ITS metabarcoding data from 2,400 root representing 386 barley lines across spring and winter field trials, we quantified host geneti
- Europe PMC · Published · First archived
A transcriptomic readout of chromosomal instability reveals genome-stress states beyond proliferation in colorectal cancer ↗
Abstract Background. Chromosomal instability (CIN) is a defining feature of colorectal cancer (CRC), yet its quantification is limited by the availability of DNA copy-number data, and most existing expression-based CIN signatures largely recapitulate proliferation. We aimed to develop and validate a DNA copy-number-anchored transcriptomic index that measures CIN itself. Methods. A DNA-level CIN_index was built in TCGA-COAD by integrating copy-number breakpoint burden, fraction of genome altered and arm-level gain/loss events (PCA). A 38-gene mRNA-CIN model was derived by WGCNA and XGBoost/Boru
- Europe PMC · Published · First archived
Extracellular Vesicles as a Proposed Third Signalling Component of Paget’s Seed‐And‐Soil Theory ↗
Paget’s seed-and-soil theory explains why cancer spreads to some organs and not others. It describes a travelling tumour cell that meets a receptive organ. It does not say how the organ becomes receptive. Extracellular vesicles (EVs) carry proteins and RNA between cells, and in experimental models tumour EVs can prepare a distant organ before tumour cells arrive [1–6]. We propose EVs as a third signalling component of Paget’s scheme: a signal that can travel ahead of the cell. It does not replace the seed, and preparing a tissue is not metastasis. We also place two further findings in this fra
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Check each original source for its methods, release status, limitations, and supporting data. A repository announcement, a preprint, and a published study provide different kinds of evidence. SYMTRI’s subject classification helps discovery; it does not independently validate the source’s claims.
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