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Earlier sources: Science
Science investigates the natural world through observation, experiments, and mathematical models. Explore papers and developments in biology, medicine, materials, neuroscience, physics, climate, and mathematics; a reported finding is not necessarily established consensus.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗1632 classified signals in the fourteen-day window. Recent momentum: steady. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- Europe PMC · Published · First archived
AMPK Activator MK-8722 Improves Spatial Memory Deficit and Alters Metabolome in APP/PS1 AD Mouse Model. ↗
Alzheimer's disease (AD) involves early synaptic vulnerability and systemic metabolic dysfunction, yet the impact of peripheral metabolic state on brain function remains unclear. Previous studies indicate a link between AMP-activated protein kinase (AMPK) signaling dysregulation and AD pathophysiology. Here we tested whether systemic treatment of a potent pan-AMPK activator MK-8722 influences cognitive function, synaptic plasticity, and circulating metabolic profiles in APP/PS1 AD model mice at the age of 6-8 months. MK-8722 was well tolerated and activated AMPK in the liver but not in the hip
- Europe PMC · Published · First archived
Optimizing Rainwater Harvesting Site and Structure Suitability Using Geospatial, Multi-Influencing Factor, and Analytic Hierarchy Process Approaches. ↗
Rainwater harvesting (RWH) is an essential practice for water conservation, improved water resource management, and water-related hazards mitigation in mountainous areas. Selection of a suitable site and an appropriate structure of the RWH facility are vital for improving water availability and agricultural productivity under all circumstances, particularly due to climate change-related hydrological uncertainty. It is challenging to evaluate and analyze RWH sites across diverse conditions worldwide, particularly in remote, inaccessible mountainous areas where these sites have significant impac
- Europe PMC · Published · First archived
Exosomal miRNA Sequencing and Bioinformatics in Breast Cancer: A Case-Control Study in Baise, China. ↗
Breast carcinoma remains the most frequently diagnosed malignancy among women globally, carrying a substantial burden of incidence and fatality. Timely diagnosis and intervention are of utmost significance for improving patient prognosis. Accumulating evidence suggests that microRNAs (miRNAs) derived from plasma exosomes may serve as potential diagnostic biomarkers for mammary carcinoma. To conduct an exploratory analysis of the role of exosomal miRNAs, expression profiles were obtained from breast cancer patients and healthy controls recruited between February 20, 2025, and May 20, 2025 (a 3-
- Europe PMC · Published · First archived
Portable CRISPR/Cas12a-Based Aptasensor System for Point-of-Care Detection of Cytokine Tumor Necrosis Factor-Alpha (TNF-α). ↗
Tumor necrosis factor-α (TNF-α) is an important inflammatory cytokine whose rapid and quantitative detection is essential for disease diagnosis and monitoring. However, conventional methods are often limited by bulky instrumentation and are not well suited for analysis in complex biological environments. Herein, a portable CRISPR/Cas12a-based aptasensor system was developed for detection of TNF-α by integrating aptamer recognition, Cas12a trans-cleavage signal amplification, and a miniaturized fluorescence detection device. An aptamer for TNF-α was designed to regulate the accessibility of the
- Europe PMC · Published · First archived
Multimodal Ageing Biomarkers and Plasma Proteomic Signatures Associated With All-Cause Mortality. ↗
Ageing biomarkers quantify molecular, physiological or functional features that vary between individuals as they age and may improve prediction of health outcomes beyond chronological age. Recently, plasma proteomics have been used to estimate the biological ages of 11 human organs. Although accelerated organ ageing is associated with higher mortality risk, systematic benchmarking against established ageing biomarkers is lacking. Here, we pursued two complementary aims. First, we benchmarked proteomic organ clocks against multimodal ageing biomarkers for associations with 16-year all-cause mor
- Europe PMC · Published · First archived
Brain Dynamics Underlying Reaching Movements Under Uncertainty. ↗
Motor responses are influenced by inferred predictability, but it remains unclear how uncertainty, or its inverse, precision, is encoded within motor control networks. In this study, we combined computational modeling of reaching movement response speed with functional magnetic resonance imaging (fMRI). We used a cueing paradigm with changing cue predictability (~50%, ~70%, and ~90%) to test how predictive inference about left/right reaching responses affected cortical activity and network connectivity in 28 healthy young adults. Behavioral results showed that the response speed differences be
- Europe PMC · Published · First archived
Individualised Structural and Functional Frontostriatal Connectivity Mapping in Adult ADHD. ↗
Abundant research from early neurocognitive models to recent mega-analyses has highlighted the central role of frontostriatal circuits in attention deficit hyperactivity disorder (ADHD). However, it remains unclear which specific aspects of functionally organised frontostriatal loops are affected by ADHD and how these disruptions differ across individuals in light of the disorder's marked heterogeneity. We investigated frontostriatal connectivity in individualised circuits in 40 adults with ADHD and 36 neurotypical controls using a multimodal dataset that included diffusion-weighted magnetic r
- Europe PMC · Published · First archived
Stretch-Induced Muscle Responses Under Threat Versus Safety. ↗
When in a stressful situation, making fast and accurate decisions is crucial. Previous work has shown that sensorimotor decisions can improve under threat. However, it is unclear if these improvements are achieved by improvements in perceptual or motor performance. Here, we present two hypotheses for how threat might influence motor preparation and use muscular stretch reflexes to test both. The task-unspecific hypothesis predicts that threat promotes motor preparation irrespective of the reach target, through tonic upregulation of the short latency stretch reflex. In contrast, the task-specif
- Europe PMC · Published · First archived
EndoPRS-SS: Summary-statistic based incorporation of endophenotypes to improve risk prediction. ↗
Endophenotypes are critical biological markers with genetic links to disease progression. We previously developed endoPRS, a multi-trait polygenic risk score (PRS) method that leverages endophenotype data to improve disease risk prediction. However, endoPRS requires individual-level genotype-phenotype data for model fitting, restricting its broader use. To address this, we introduce endoPRS-SS, an extension which enables PRS inference using genome-wide association study (GWAS) summary statistics and LD reference panels. Through simulation and real data analysis, we demonstrate that endoPRS-SS
- Europe PMC · Published · First archived
An SAPK10-RISBZ1-ABT axis promotes endosperm-to-embryo ABA transport to enhance pre-harvest sprouting tolerance in rice. ↗
Weak dormancy can lead to pre-harvest sprouting (PHS) of crops, which seriously affects grain yield and quality. During seed development, endosperm-derived ABA is transported into embryo to prevent PHS. However, the underlying molecular mechanism remains unclear. Here, we report the map-based cloning of PHS7, encoding an ABA-inducible bZIP transcription factor RISBZ1, positively regulates PHS tolerance. Through an ‶SAPK10- RISBZ1-ABT″ module, the SnRK2 family kinase SAPK10 senses the ABA signal to phosphorylate RISBZ1 at Ser190, thus enhance its transactivation activity on an ABC transporter g
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Check each original source for its methods, release status, limitations, and supporting data. A repository announcement, a preprint, and a published study provide different kinds of evidence. SYMTRI’s subject classification helps discovery; it does not independently validate the source’s claims.
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