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Earlier sources: Science
Science investigates the natural world through observation, experiments, and mathematical models. Explore papers and developments in biology, medicine, materials, neuroscience, physics, climate, and mathematics; a reported finding is not necessarily established consensus.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗1635 classified signals in the fourteen-day window. Recent momentum: steady. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- Europe PMC · Published · First archived
Single-nucleus transcriptome atlas of Brassica developing seeds provides cellular and molecular insights into embryo abortion in interspecific hybrids. ↗
Embryo rescue has been used to recover abortive seeds in distant hybridization; however, its efficiency remains low and rescue frequently fails because the genetic basis of embryo abortion is poorly understood. To address this, time-series single-nucleus RNA sequencing (snRNA-seq) was performed on developing seeds from interspecific crosses between Brassica campestris (syn. Brassica rapa) ssp. chinensis and Brassica oleracea, and compared them to seeds from B. campestris intraspecific crosses. Our analysis of single-nucleus transcriptomic profiles revealed that during normal seed development,
- Europe PMC · Published · First archived
Aging Disrupts Tissue Homeostasis and Constrains Blastema-Mediated Regeneration in the Cladonema Medusa. ↗
Regenerative capacity varies widely across animals, yet aging is often accompanied by declining tissue homeostasis and regenerative potential. In many species, regeneration of complex structures relies on epimorphic programs that form a blastema, coordinating cell proliferation and pattern reorganization after injury. Although aging-associated regeneration defects have been documented in several bilaterian models, how aging shapes regeneration in early-branching metazoans with robust regenerative abilities remains unclear. Here, we investigate aging and regeneration in the medusa stage of Clad
- Europe PMC · Published · First archived
Building recurring public and patient involvement in adult autism psychiatry and neurodevelopmental research: lessons from the first year of a patient panel and advisory board. ↗
Public and patient involvement (PPI) is increasingly emphasized in health and autism research, yet involvement is often organized around individual research projects. Less is known about the practical and organizational processes involved in developing recurring PPI structures across clinical and academic settings. This paper describes and critically reflects on the establishment, implementation, and first-year experiences of two recurring PPI structures in western Sweden: a Patient Panel linked to an adult autism psychiatry service and a Neurodevelopmental Disorders (NDD) Advisory Board based
- Europe PMC · Published · First archived
In vivo detection of pathologic α- synuclein and TDP-43 in the skin and olfactory mucosa of a patient with Parkinson's disease-like phenotype carrying the p.Thr272Serfs*10 GRN mutation. ↗
We describe a patient carrying the GRN p.Thr272Serfs*10 mutation, who presented with parkinsonism at onset and later developed prodromal frontotemporal dementia, in whom seed amplification assay on olfactory mucosa and skin analyses suggest mixed TDP-43 and α-synuclein co-pathology, highlighting how combining these techniques could provide a comprehensive approach to investigate the underlying neuropathological process.
- Europe PMC · Published · First archived
Mitochondrial genetic variation as a novel predictor of graft-versus-host disease after stem-cell transplantation in myelodysplastic neoplasms. ↗
Graft-versus-host disease (GvHD) remains a major cause of morbidity and non-relapse mortality after allogeneic hematopoietic cell transplantation. Building on prior evidence implicating mitochondrial DNA (mtDNA) variation in myelodysplastic neoplasms (MDS), we investigated the prognostic impact of recipient and donor mtDNA variation on acute and chronic GvHD. Whole‑genome sequencing was performed on pretransplant samples from 494 MDS donor-recipient pairs (discovery cohort) from the Center for International Blood and Marrow Transplant Research (CIBMTR). Associations between mtDNA variations an
- Europe PMC · Published · First archived
ZNF292 mutations impair RNA and protein biosynthesis defining an adverse prognostic subset in early-stage chronic lymphocytic leukemia. ↗
ZNF292 alterations are recurrently detected in patients with chronic lymphocytic leukemia (CLL), occurring in 3%-6% of patients as mutations and in 2% as 6q deletions. Although preliminary evidence suggested an independent prognostic role for ZNF292 mutations, their specific clinical relevance in early-stage CLL and the underlying biological mechanisms remain poorly defined. 488 CLL patients were analyzed using targeted Next-Generation Sequencing (NGS) to characterize the landscape and clinical significance of ZNF292 mutations. CRISPR/Cas9-genome editing was employed to introduce the most prev
- Europe PMC · Published · First archived
Milk and infant plasma hormone concentrations predict sweet and fat taste acceptance and later food intake. ↗
Early-life exposure to metabolic hormones may influence the development of taste acceptance and subsequent intake of hyperpalatable foods (HPF) in infants, but evidence integrating hormonal, behavioral, and dietary data in humans is limited. Therefore, our objective was to determine whether concentrations of insulin, leptin, cortisol, and liver-expressed antimicrobial peptide 2 (LEAP2) in human milk and infant plasma at 6 months predict infant sweet and fat taste acceptance and HPF intake later in infancy. In this prospective cohort study, human milk and infant plasma were collected at 6 month
- Europe PMC · Published · First archived
Effects of naringenin on superovulation in mice: evaluation of zygote and blastocyst development, histopathology, and molecular docking insights. ↗
Naringenin is a citrus-derived flavanone with documented antioxidant, anti-inflammatory, and steroidogenic modulatory properties; yet, its effects under gonadotropin-stimulated superovulation have not been investigated. This study evaluated the impact of naringenin co-administration during a pregnant mare serum gonadotropin (PMSG)/human chorionic gonadotropin (hCG) superovulation protocol on zygote yield, preimplantation embryo development, and ovarian and endometrial morphology in CD-1 mice. Twenty-four females (8-10 weeks) received PMSG with either naringenin (20 mg/kg intraperitoneally; n =
- Europe PMC · Published · First archived
Parental brain responses to own and unknown children's emotional facial expressions: An fMRI study. ↗
The parent-child relationship is crucial for children's socio-emotional development. Previous research, mostly in mothers of infants, has implicated neural networks subserving reward, saliency, and theory of mind (ToM). In this preregistered study, we sought to extend these findings to fathers and older children by examining maternal and paternal brain responses to preschool-aged children's emotional faces. Our investigation included 89 parents (41 mothers, 48 fathers) and their children (44 daughters, 45 sons). We examined the effects of children's facial identity (own, unknown) and emotion (
- Europe PMC · Published · First archived
Portable Deep Learning-Assisted Device for Automated Interincisal Opening Assessment and Oral Submucous Fibrosis Lesion Identification: A Translational Clinical Study. ↗
Oral submucous fibrosis (OSMF) is a chronic, progressive, potentially malignant disorder prevalent in Southeast Asia and the Indian subcontinent. Progressive fibrosis restricts mouth opening, making interincisal opening as a key parameter of disease staging. This study developed a portable AI-based device for automated interincisal opening measurement and OSMF lesion detection important for real-time screening and staging. A portable device powered by a quad-core ARM Cortex-A72 processor integrates a YDLiDAR depth camera for interincisal opening measurement and an intraoral camera for image ac
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How to assess evidence about Science
Check each original source for its methods, release status, limitations, and supporting data. A repository announcement, a preprint, and a published study provide different kinds of evidence. SYMTRI’s subject classification helps discovery; it does not independently validate the source’s claims.
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