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Earlier sources: Science
Science investigates the natural world through observation, experiments, and mathematical models. Explore papers and developments in biology, medicine, materials, neuroscience, physics, climate, and mathematics; a reported finding is not necessarily established consensus.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗1616 classified signals in the fourteen-day window. Recent momentum: steady. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- OpenAlex · Published · First archived
Therapeutic Advances in Duchenne Muscular Dystrophy: Regulatory Milestones, Emerging Modalities, and Implications for Clinical Practice ↗
Review articleDuchenne muscular dystrophy (DMD) is undergoing rapid therapeutic change, driven by mutation-specific treatments, gene-based interventions, and non-gene disease-modifying approaches.At the same time, regulatory decisions and emerging safety data increasingly determine which therapies can be used, in which patients, and under what monitoring conditions.This review provides a clinically focused synthesis of approved and late-stage therapies, including corticosteroids and the dissociative steroid vamorolone, exon-skipping antisense oligonucleotides, the histone deacetylase inhibitor…
- OpenAlex · Published · First archived
Frame-Rate-Independent High-Frequency 3D-DIC Vibration Measurement Enabled by Stroboscopic Equivalent-Time Sampling and Physics-Guided Spatiotemporal Filtering ↗
High-frequency full-field vibration measurement using three-dimensional digital image correlation (3D-DIC) is limited by the trade-off between camera frame rate, spatial resolution, and measurement noise. This study presents a method to overcome the frame-rate limitation of 3D-DIC vibration measurement by combining stroboscopic equivalent-time sampling with spatiotemporal noise decoupling. Short-pulse stroboscopic illumination freezes structural motion at different vibration phases, allowing a low-frame-rate stereo camera system to reconstruct high-frequency periodic responses through inter-cy…
- OpenAlex · Published · First archived
Immunoinformatic Design and Structural Evaluation of a Full-Length mRNA Vaccine Targeting Rabies Glycoprotein G ↗
Background/Objectives: Rabies remains a fatal viral disease, and current conventional vaccine strategies face significant challenges regarding structural stability and large-scale manufacturing. This study aimed to design a novel messenger ribonucleic acid (mRNA) vaccine candidate targeting the rabies virus glycoprotein G (RABV-G) using an integrated immunoinformatic and structural modeling framework. Methods: The RABV-G sequence was systematically evaluated for evolutionary conservation and safety, followed by 3D structural modeling. Highly antigenic B-cell and T-cell epitopes were identified…
- OpenAlex · Published · First archived
A comprehensive analysis of molecular epidemiology and clinical characteristics of human adenovirus among hospitalized children with pneumonia in Tianjin, China, 2022–2025 ↗
Human adenoviruse (HAdV) is a major pathogen associated with acute respiratory infections (ARIs) in children worldwide. However, the epidemiological and genotypic characteristics of HAdV among pediatric inpatients with ARIs have not been fully elucidated in Tianjin. Therefore, this study aimed to examine the epidemiological features, genotype distribution, and clinical associations of HAdV infection in this population. Respiratory specimens were collected from children hospitalized with ARIs between September 2022 and August 2025. Targeted next-generation sequencing was used for initial screen…
- OpenAlex · Published · First archived
Twisted Rényi negativity as a reliable proxy for mixed-state entanglement in fermionic systems ↗
Characterizing mixed-state entanglement in fermionic quantum matter represents a fundamental challenge at the intersection of condensed matter physics and quantum information. Unlike pure states, mixed states lack a universally accepted and easily computable entanglement measure, a difficulty compounded in fermionic systems by the ambiguity of the partial transpose operation. Here, motivated by the Hermiticity of the partially transposed density matrix and the analytic continuation of the Rényi negativity to logarithmic negativity, we address this puzzle by demonstrating the "twisted" Rényi ne…
- OpenAlex · Published · First archived
The protein kinase IKK epsilon shapes the melanoma tumor microenvironment by modulating angiogenesis and the T-cell immunity ↗
BACKGROUND: Inhibitor of nuclear factor kappa-B kinase epsilon (IKKε) contributes to tumorigenesis and metastasis in various cancers. In melanoma, it is overexpressed and constitutively active. Inhibition of IKKε by either knockdown or pharmaceutical compounds reduce tumor progression by suppressing key molecular pathways within melanoma tumor cells. However, within the tumor microenvironment (TME), the role of this protein remains to be fully elucidated. METHODS: Multiplex immunohistochemistry was performed on human primary melanomas to assess IKKε expression in tumor and immune cell compartm…
- OpenAlex · Published · First archived
Single-molecule imaging reveals DNA shape read-out by the INO80 chromatin remodeler ↗
ATP-dependent chromatin remodeling enzymes act together to construct complex chromatin architectures around functionally important regulatory regions like promoters and origins of replication (ORI). The INO80 complex accurately positions nucleosomes bordering these regions, which is crucial for proper transcription start site selection and efficient replication. How INO80 localizes these nucleosomes and regulates its remodeling activity to produce specific positions mechanistically is unclear, although recent findings suggest a role for DNA shape features and barrier factors. Here, we use sing…
- OpenAlex · Published · First archived
Genetic resistance confers protection against clinical severity, intestinal colonization, and mortality in weaned pigs experimentally challenged with pathogenic F18 and F4 InPEC Escherichia coli ↗
Abstract Post-weaning colibacillosis (PWC) is a leading cause of morbidity and mortality in nursery pigs, affecting a large proportion of individuals on affected farms, caused by intestinal pathogenic Escherichia coli (E. coli) (InPEC). Its control requires comprehensive control strategies, including measures to address multidrug-resistant E. coli strains and reduced susceptibility to disinfectants. This study assessed the clinical outcome in two pig lines with distinct genetic susceptibility to enterotoxigenic E. coli: a resistant line (Genotype A) and a susceptible line (Genotype B), followi…
- OpenAlex · Published · First archived
Ethical decisions under uncertainty? Guidance for initiating first-in-human trials involving genome editing ↗
First-in-human studies involving gene transfer or genome editing give rise to complex uncertainties. There is a broad acknowledgment that the current scientific guidelines should be supplemented with ethical guidance, particularly with regard to decisions about whether to initiate such trials. As a first step toward this goal, we present a three-tiered conceptual framework that operationalizes ethical principles to provide researchers with guidance on this decision. In the first “diagnostic” step, researchers are invited to identify the drivers of uncertainty in their study and to collaborativ…
- OpenAlex · Published · First archived
Source-Dependent Renal Effects of Commercial Protein Supplements: A 28-Day Study in Rats ↗
Background and Objectives: Commercial protein powders are widely consumed to increase dietary protein intake, yet whether their renal effects differ by protein source remains poorly characterized. The primary objective of this study was therefore to determine whether 28 days of administration of commercial whey, casein, soy or beef protein powder produces source-dependent renal histopathological injury in rats, with the total renal injury score as the primary outcome. Secondary objectives were to assess conventional renal function markers and the renal oxidative stress response. Materials and…
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Check each original source for its methods, release status, limitations, and supporting data. A repository announcement, a preprint, and a published study provide different kinds of evidence. SYMTRI’s subject classification helps discovery; it does not independently validate the source’s claims.
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