THE INTERNET IS THINKING
Earlier sources: Science
Science investigates the natural world through observation, experiments, and mathematical models. Explore papers and developments in biology, medicine, materials, neuroscience, physics, climate, and mathematics; a reported finding is not necessarily established consensus.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗1645 classified signals in the fourteen-day window. Recent momentum: steady. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- OpenAlex · Published · First archived
Fundamentals and applications of hybrid electro- and opto- mechanical system coupled to superconducting qubit: a short review ↗
Superconducting qubits, realised by incorporating Josephson junctions into superconducting circuits, behave as artificial atoms with anharmonic energy spectra and can be precisely controlled and measured using microwave cavities within the framework of circuit quantum electrodynamics (cQED). Since its emergence in the early 2000 s, cQED has established superconducting qubits as leading candidates for scalable quantum devices and has enabled the exploration of hybrid quantum systems that integrate disparate physical platforms. This review surveys superconducting hybrid quantum electromechanical…
- OpenAlex · Published · First archived
Toward a minimal amino acid alphabet for protein design ↗
A bstract Proteins are built from 20 canonical amino acids. It is interesting to explore whether proteins can be formed from significantly reduced amino acid alphabets. Our bioinformatics survey of UniProt (more than 250 M sequences) revealed that proteins composed of reduced amino acid alphabets (< 10) are extremely rare among existing proteins. Next, we used computational protein design to design proteins composed of all 1,013 possible alphabets of 2-10 early amino acids (Ala, Asp, Glu, Gly, Ile, Leu, Pro, Ser, Thr, and Val). The length of all proteins was 100 amino acid residues. Small amin…
- OpenAlex · Published · First archived
APC/C−CDH1 suppresses AROS-mediated protection against DNA damage-induced senescence by ubiquitination ↗
Anaphase-promoting complex/cyclosome (APC/C) regulates the cell cycle by destruction of target proteins ubiquitination. However, understanding the control of APC/C has remained elusive. We identify APC2, the catalytic core subunit of APC/C, as a binding partner of active regulator of SIRT1 (AROS). Subsequent immunoprecipitation assays confirm the interaction in vivo. We reveal that AROS competes with APC11 for APC2 binding, thereby impeding the destruction of Cyclin B1. By contrast, the APC/C coactivator CDH1 ubiquitinates and degrades AROS in a D-box-dependent manner. Finally, we demonstrate…
- OpenAlex · Published · First archived
AXIAL: Attention-based eXplainability for Interpretable Alzheimer’s Localized diagnosis using 2D CNNs on 3D MRI brain scans ↗
Deep learning models for Alzheimer’s disease (AD) diagnosis from magnetic resonance imaging (MRI) have achieved high performance, but clinical adoption remains limited because reliability and generalizability remain uncertain. Reported results are often difficult to compare because cohorts and evaluation protocols differ, while model explanations are rarely assessed quantitatively. This study investigates whether attention-based models evaluated under a rigorous and reproducible protocol can provide reproducible performance estimates and biomarker-oriented population-level explanations. We pro…
- Europe PMC · Published · First archived
Proper assessment of the response to a test drug needs a treatment-free control group in the experimental design. ↗
In preclinical biomedical research, the response elicited by a test drug is commonly evaluated relative to the response produced by its vehicle, with the difference assumed to represent the magnitude of the drug's action. However, there are many reports that the administration of vehicle can provoke a measurable response. For vehicles that are presumed to be inert (e.g. saline), this likely arises from the stress of the administration procedure itself. However, for drugs that are poorly soluble in water, there is extensive evidence that their vehicles can have profound physiological and toxic
- Europe PMC · Published · First archived
Gliomas with pleomorphic and pseudopapillary features (GPAP) are circumscribed tumors with targetable mutations, prolonged survival, and frequent tumor predisposition. ↗
DNA methylation profiling of CNS tumors led to the identification of HPAP (high-grade glioma with pleomorphic and pseudopapillary features), a recently proposed entity with variable morphology, recurrent MAP-kinase pathway activating events, and longer survival compared to glioblastoma. We aimed to independently validate and further characterize this entity. We retrieved a multicentric cohort of gliomas compatible with HPAP and performed t-SNE dimensionality reduction on their DNA methylation profile. Clinical, radiological, histological, and molecular data were reviewed. Twenty tumors cluster
- Europe PMC · Published · First archived
Geographic isolation promoted species divergence of two closely related Cycas species in distinct river basins. ↗
Understanding the process of species divergence and the mechanisms that drive genetic differentiation among closely related species is essential for explaining the origins of plant biodiversity. Geographic isolation and niche differentiation are key drivers of species divergence. Cycas chenii and C. guizhouensis are morphologically similar sister species from different river basins in Southwest China. Their distinct habitats in nearby river systems make them a potentially good model system for studying species divergence. We used double-digest restriction-site-associated DNA sequencing data an
- Europe PMC · Published · First archived
Exploiting Phase Partitioning of a Giant Trimeric Fibrous Protein Scaffold to Potentiate Chitinase-Driven Antifungal Activity. ↗
Recently, the relationship between phase-separation behavior and biological functions in both natural and artificial systems has garnered significant attention. An aqueous two-phase system (ATPS) composed of polyethylene glycol (PEG) and dextran (Dex), traditionally utilized for protein purification, has emerged as a model for liquid-liquid phase separation (LLPS). In this study, we found that Cstalk, a giant trimeric fibrous protein with a length of approximately 40 nm, preferentially partitions to the Dex-rich phase in PEG/Dex ATPS. Consequently, conjugation of a protein of interest (POI) to
- Europe PMC · Published · First archived
Clinical progress note: Management of the hospitalized patient with medetomidine withdrawal. ↗
Medetomidine is an ⍺2 adrenergic agonist that has rapidly emerged as an adulterant in the US illicit opioid supply. Clinicians should suspect medetomidine exposure when opioid overdoses respond poorly to naloxone. Medetomidine withdrawal is clinically distinct from opioid and xylazine withdrawal and should be suspected when a patient with opioid withdrawal presents with significant rebound sympathetic activation, including hypertension, tachycardia, tremor, agitation, and refractory vomiting despite opioid agonist treatment. Management requires concurrent treatment of opioid withdrawal, early
- Europe PMC · Published · First archived
Engineering a TurboID-based proximity labeling tool to track the dynamic secretomes under salt stress. ↗
Secretory proteins are essential for plant development and environmental adaptation, yet selectively profiling cargoes transported through the conventional endoplasmic reticulum (ER)-Golgi pathway remains technically challenging because apoplastic secretomes contain proteins from multiple secretion routes. We developed an ER-anchored TurboID proximity labeling method to selectively enrich proteins entering the conventional secretory pathway in Arabidopsis thaliana. Quantitative proteomics under control and salt stress conditions identified dynamic secretome changes and showed that most enriche
Live window recorded . This is the ingestion observation time, not the publication or discovery date of each source.
How to assess evidence about Science
Check each original source for its methods, release status, limitations, and supporting data. A repository announcement, a preprint, and a published study provide different kinds of evidence. SYMTRI’s subject classification helps discovery; it does not independently validate the source’s claims.
See the collection and counting methodology ↗ · Read the weekly synthesis ↗
Follow a thread
Explore related regions
These navigation suggestions are part of the map’s editorial structure, rather than measured evidence of a connection.