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Earlier sources: Science
Science investigates the natural world through observation, experiments, and mathematical models. Explore papers and developments in biology, medicine, materials, neuroscience, physics, climate, and mathematics; a reported finding is not necessarily established consensus.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗1520 classified signals in the fourteen-day window. Recent momentum: steady. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- OpenAlex · Published · First archived
Enzyme‐mediated remodeling of the extracellular matrix and glycocalyx to enhance immunotherapy in solid tumors ↗
Abstract The tumor‐associated extracellular matrix (ECM) and glycocalyx form a dynamic barrier that provides physical shielding and immunosuppressive signaling, leading to therapeutic resistance. A growing body of evidence supports enzyme‐based strategies to remodel these barriers and improve therapeutic access to tumors. This review examines enzymes that act as “path cleansers” by cleaving components of the ECM or the glycocalyx to restore the efficacy of immunotherapies. Moreover, some enzymes may exert effects beyond barrier remodeling, including modulation of signaling pathways, enhancemen…
- OpenAlex · Published · First archived
Cardiac amyloidosis and coronary artery disease: an overlooked clinical intersection ↗
Cardiac amyloidosis has emerged as an important and underrecognized cause of heart failure with preserved ejection fraction, particularly in elderly patients who commonly carry concomitant coronary artery disease. The coexistence of these two conditions creates a layered diagnostic and therapeutic problem. Epicardial atherosclerosis is present in roughly 30-40% of patients with cardiac amyloidosis, yet the dominant ischemic mechanism in the amyloidotic heart is rarely flow-limiting epicardial obstruction. Instead, ischemia is driven by coronary microvascular dysfunction arising from amyloid in…
- OpenAlex · Published · First archived
A developmental single-cell atlas of the Drosophila visual system glia reveals cell type diversification and subcellular mRNA compartmentalization ↗
Glial cells are essential for proper nervous system development and function. To understand glial development and function, we comprehensively annotated the glial cells from two large single-cell mRNA-sequencing (scRNA-seq) atlases of the developing Drosophila visual system. This allowed us to identify all glial cell types from larval to adult stages and follow their developmental trajectories to understand how the diversity of glial types is generated during development. We show that whereas most glial types, such as chiasm glia, gradually change their transcriptome as they mature during deve…
- OpenAlex · Published · First archived
The genome sequence of Red Currant, Ribes rubrum L., 1753 (Saxifragales: Grossulariaceae) ↗
We present a genome assembly of Ribes rubrum (Red Currant; Streptophyta; Magnoliopsida; Saxifragales; Grossulariaceae). The two haplotypes have lengths of 834.25 megabases and 821.88 megabases. Most of the haplotype 1 assembly (95.96%) was assigned to 8 chromosomal pseudomolecules. Haplotype 2 was assembled to scaffold level. The mitochondrial sequence has a length of 531.84 kilobases and the plastid genome assembly has a length of 157.8 kilobases. Gene annotation of this assembly by Ensembl identified 28,910 protein-coding genes. This assembly was generated as part of the Darwin Tree of Life…
- OpenAlex · Published · First archived
Accuracy of Four Intravenous Infusion Devices in a Clinical Setting: A Randomized Controlled Trial ↗
Introduction/Objective Accurate delivery of intravenous fluids is essential for patient safety, but the flow rate accuracy of different infusion devices in clinical settings remains incompletely characterized. This study aims to compare the flow rate accuracy of four intravenous infusion devices-Terufusion TE-112, Volumed μVP7000, Auto Clamp, and Infucon-across multiple flow rates in patients undergoing elective surgery under general anesthesia. Methods In this single-center, randomized controlled trial, 80 adult patients (ASA physical status 1–2) scheduled for elective surgery of more than 2…
- OpenAlex · Published · First archived
A Physics-Informed ConvFormer with State-Space Gating for Smartphone-Based Human Activity Recognition on the WISDM Dataset ↗
Smartphone-based human activity recognition (HAR) requires discriminative temporal modeling and careful assessment of computational cost. This study evaluates a Physics-Informed ConvFormer with State-Space Gating for six-class HAR on the WISDM v1.1 accelerometer dataset. The model combines raw acceleration with deterministic magnitude, directional, gravity-estimate, and dynamic-acceleration features, followed by large-kernel depthwise convolution, a Mamba-inspired causal gate, attention, and a multilayer perceptron. The main subject-level experiment achieved 95.63% best validation accuracy and…
- OpenAlex · Published · First archived
Exploratory screening of wild-game tissues in Japan toward value-added utilization: estimated soluble protein/peptide yields and DPPH radical-scavenging and ACE-inhibitory activities after in vitro digestion ↗
Abstract This exploratory study aimed to compare estimated soluble protein/peptide yields and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging and angiotensin-converting enzyme (ACE)-inhibitory activities after in vitro digestion of eight tissues from wild-caught sika deer and wild boar and corresponding cattle and pig tissues, with relevance to value-added utilization in Japan. Eight tissues were obtained from sika deer and wild boar (n = 5 each) and commercially sourced cattle and pigs (n = 3 per tissue per species). Heated samples underwent gastric and intestinal digestion. DPPH and…
- OpenAlex · Published · First archived
In-silico Vaccine Candidate Peptides Against Urinary Tract Infection in Humans Using Uropathogenic Escherichia Coli - Uti89 Strain ↗
The rising antibiotic resistance of UPEC strains highlights the need for alternate preventive measures for urinary tract infections (UTIs) brought on by Uropathogenic Escherichia coli (UPEC) strain Uti89. This in silico study (2022-25) used a subtractive genomics-based reverse vaccinology approach; data extraction, protein analysis, epitope prediction, docking analysis, protein-ligand complexes, molecular dynamics, Human immune simulation, fragment Inserted in vector (pET-28a (+) were all steps in the study's multi-step methodology to find a potential vaccine candidate against UTIs. 3,840 non-…
- OpenAlex · Published · First archived
Chromatin Accessibility Profiling of the Canine Brain Reveals Regulatory Programs Associated With Dog‐Wolf Divergence and Human Psychiatric Risk ↗
The domestic dog has emerged as a valuable model for investigating the biology of social behavior and neuropsychiatric disease, yet a comprehensive map of gene regulatory elements across the canine brain is still lacking. Here, we generated an ATAC-seq atlas spanning seven major brain regions and the pituitary gland from four adult beagle dogs. We identified 251,492 putative cis-regulatory elements (CREs) and found that chromatin accessibility profiles resolve anatomically distinct regions into discrete regulatory modules, including striatal, cortical-associated, hypothalamic/habenular, and pi…
- OpenAlex · Published · First archived
A physics-informed B-spline reconstruction of flow data ↗
Continuous B-spline models provide compact, differentiable representations of discrete flow snapshots, but data-only fitting does not control consistency with prescribed governing equations. We introduce physics-informed B-spline reconstruction (PI-BSR), a post hoc method that optimizes a fixed tensor-product B-spline representation of a completed flow trajectory. PI-BSR combines data fidelity with soft residuals for the governing partial differential equations, initial and boundary conditions, and integral balances over spatial subdomains. A shared-face construction ensures algebraic cancella…
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How to assess evidence about Science
Check each original source for its methods, release status, limitations, and supporting data. A repository announcement, a preprint, and a published study provide different kinds of evidence. SYMTRI’s subject classification helps discovery; it does not independently validate the source’s claims.
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