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Earlier sources: Science
Science investigates the natural world through observation, experiments, and mathematical models. Explore papers and developments in biology, medicine, materials, neuroscience, physics, climate, and mathematics; a reported finding is not necessarily established consensus.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗1522 classified signals in the fourteen-day window. Recent momentum: steady. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- OpenAlex · Published · First archived
Accelerated discovery of thermostable mRNA–lipid nanoparticle vaccines using data-efficient AI ↗
The instability of mRNA−lipid nanoparticles (LNPs) necessitates ultra-cold storage, limiting global distribution and their broader application in advanced delivery systems. Solid-state, water-free formulations enhance thermostability and enable integration into emerging delivery modalities such as microneedle patches. Previous efforts to stabilize mRNA−LNPs have been constrained by narrow formulation scope and low-throughput screening methods. Here we introduce Algorithm-Guided Experimental design for lipid Nanoparticle Thermostabilization (AGENT), an artificial intelligence (AI)-driven framew…
- OpenAlex · Published · First archived
Pathogen genome enrichment sequencing to support a city-wide Legionnaires’ disease outbreak investigation ↗
Pathogen genomics can provide high-confidence source attribution for epidemiological investigations of Legionnaires' disease (LD) outbreaks. However, the utility of culture-based genomics can be undermined by long lead times for Legionella pneumophila culture or a lack of isolates when dealing with non-culturable bacteria or low-biomass specimens. Here, during a large 2024 LD outbreak in Melbourne, Australia, we compared direct specimen, hybridization-based enrichment sequencing with traditional culture-based whole-genome sequencing of 18 clinical and 5 environmental L. pneumophila specimens.…
- OpenAlex · Published · First archived
MCM10 and SLD-2/RECQL4 jointly activate the CMG helicase during metazoan DNA replication initiation ↗
Eukaryotic cells regulate the assembly and activation of the essential DNA helicase at the heart of the chromosome replication machinery, to ensure that the chromosomes are copied just once per cell cycle. The Mcm10 protein is essential for helicase activation in budding yeast, but an equivalent role for MCM10 orthologues in animal cells has not been explored. Moreover, complete deletion of the mcm-10 gene is viable in the nematode Caenorhabditis elegans, suggesting the involvement of additional factors. Here we show that MCM-10 and a second factor called SLD-2 are recruited to chromatin after…
- OpenAlex · Published · First archived
Can physics review catch prescription and PTV margin errors in fully automated radiotherapy plans? A hazard study ↗
Abstract Purpose End‐to‐end AI‐based automated contouring and radiotherapy planning systems promise substantial gains in efficiency and consistency but also introduce new safety risks, including user input errors that occur early in the workflow. This study evaluates the ability of standard physics plan review to detect user errors in prescription and planning target volume (PTV) margin entry in a fully automated planning workflow. Methods A prototype of the Radiation Planning Assistant (RPA) was used to generate fully automated prostate cancer treatment plans for 20 patients. Five cases inten…
- OpenAlex · Published · First archived
Physics-Based Waveform Representation for Geometry-Aware Object Recognition ↗
This paper presents the RaDICAL sensing framework, a monostatic passive radar concept that combines a Sparse Uniform Circular Array (SUCA), deterministic multifrequency dither, and dictionary-based waveform recognition for target detection and classification. Rather than forming conventional spatial images or relying primarily on Doppler processing, RaDICAL encodes target geometry directly into a composite receiver waveform and performs hypothesis testing by matching measured signals to a library of predicted responses. This study develops the SUCA-based signal model for point and extended tar…
- OpenAlex · Published · First archived
Whole-Genome Analysis of Genomic Diversity and Antimicrobial Resistance Among Clinical Klebsiella pneumoniae Isolates from Farwaniya Hospital in Kuwait ↗
Background: K. pneumoniae is a major opportunistic pathogen recognized by the World Health Organization as a critical-priority antimicrobial-resistant pathogen. This study characterized isolates for antibiotic resistance determinants, virulence-associated genes, mobile genetic elements, and population structure of the isolates, and evaluated the correlation between antimicrobial resistance genotype and phenotype. Methods: Ninety-five isolates were collected from different clinical specimens in August–December 2024 in Farwaniya Hospital, Kuwait. Fifty-six isolates were selected for whole-genome…
- OpenAlex · Published · First archived
A multidimensional trustworthiness evaluation framework for AI-enabled clinical decision support: a HER2 breast cancer case study ↗
Abstract Machine learning models are increasingly being incorporated into AI-enabled decision-support systems, particularly in high-stakes domains such as healthcare. However, evaluation of such systems continues to rely predominantly on predictive performance metrics, which provide only a partial assessment of whether an AI-based decision-support system can be considered trustworthy for consequential decision-making. Recent advances in trustworthy artificial intelligence (AI) emphasize that characteristics such as explainability, reliability, robustness, and domain relevance should also be co…
- OpenAlex · Published · First archived
Refining the Immersive Technology Evaluation Measure for Virtual Reality Clinical Skills Among Native Arabic-Speaking Medical Students: Qualitative Study ↗
Abstract Background Extended reality technologies, including virtual reality (VR), augmented reality, and mixed reality, are increasingly used in medical education to create immersive and interactive learning environments. As these modalities expand, validated instruments are needed to measure learners’ experiences accurately. The Immersive Technology Evaluation Measure (ITEM) is a multidomain questionnaire assessing immersion, motivation, cognitive load, usability, and debriefing. Although cognitive interviewing informed its original development, less is known about how ITEM questions functio…
- OpenAlex · Published · First archived
Matrix conditioning and magnetic bead target transfer for fluorescence aptamer-CRISPR/Cas12a detection of kanamycin in river water ↗
Fluorescence aptamer-CRISPR/Cas12a assays provide efficient signal conversion and amplification for the detection of small molecules. However, their practical application in complex environmental water remains limited. Matrix components can cause signal loss before CRISPR amplification. In this study, a fluorescence aptamer-CRISPR/Cas12a assay was developed by integrating matrix conditioning and magnetic bead target transfer for kanamycin (KAN) detection in complex water matrices. Matrix conditioning reduced interference from humic acid (HA) and inorganic ions, while magnetic bead target trans…
- OpenAlex · Published · First archived
Association between habitual physical activity and mitochondrial DNA copy number in healthy middle-aged adults ↗
Abstract Mitochondrial dysfunction is linked to metabolic disturbances, and mitochondrial DNA copy number (mtDNAcn) is widely recognized as an accessible biomarker of mitochondrial content and capacity. Although physical activity (PA) may support mitochondrial health, its relationship with mitochondrial function remains unclear. This study examined the association between PA and mtDNAcn in middle-aged South Korean adults. This cross-sectional study included 256 community-dwelling middle-aged adults. Subjective PA was assessed using the Korean version of the International Physical Activity Ques…
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How to assess evidence about Science
Check each original source for its methods, release status, limitations, and supporting data. A repository announcement, a preprint, and a published study provide different kinds of evidence. SYMTRI’s subject classification helps discovery; it does not independently validate the source’s claims.
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