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Earlier sources: Science
Science investigates the natural world through observation, experiments, and mathematical models. Explore papers and developments in biology, medicine, materials, neuroscience, physics, climate, and mathematics; a reported finding is not necessarily established consensus.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗1622 classified signals in the fourteen-day window. Recent momentum: steady. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- Europe PMC · Published · First archived
Repeatability of an SD-OCT biometer (MS-39 AL) and agreement with a validated biometer (IOLMaster 700). ↗
Purpose To evaluate the repeatability of biometric measurements obtained with the MS-39 AL (CSO) and to assess their agreement with those provided by the IOLMaster 700 (Carl Zeiss). Setting IRCCS Bietti Foundation, Rome, Italy. Design Prospective evaluation of diagnostic test. Methods Patients were classified in Group A (with cataract) and Group B (with clear lens). For repeatability analysis, three measurements were obtained with the MS-39 AL. Agreement was analyzed by comparing the first MS-39 AL measurement with the corresponding measurement by the IOLMaster 700. Results 111 eyes were enrol
- Europe PMC · Published · First archived
Integrated cross-sectoral surveillance of antimicrobial resistance genotypes and phenotypes across disparate reservoirs. ↗
Antimicrobial-resistant (AMR) bacteria and genes are continually exchanged among humans, animals, and environmental reservoirs. Disparate and siloed surveillance methods present a major challenge for tracing and disrupting AMR transmission, with clinical monitoring focusing on detecting specific pathogens or specific genes of interest, and environmental surveys often relying on inferences drawn from indicator organisms. Here, we demonstrate that, following sample-specific pre-processing, common surveillance approaches can be applied consistently to profile AMR abundance, distribution, and phen
- Europe PMC · Published · First archived
Limited evidence for reduced learning rate adaptation in anxious-depression, before or after treatment. ↗
Background Prior research shows that humans adjust their learning rate based on environmental volatility. This adaptation has been shown to be reduced in individuals with high levels of anxious-depression, but past studies have been cross-sectional, making it unclear whether this adaptation is trait-like or responsive to treatment. There are also questions about the basic replicability of this effect with recent studies failing to find robust associations. Method In the Precision in Psychiatry study, we examined changes in learning rate adaptation in a points-loss task, following four weeks of
- Europe PMC · Published · First archived
Selective lifelong suppression of an odor processing channel in response to critical period experience. ↗
Sensory circuits undergo experience-dependent plasticity during early-life critical periods, attuning the nervous system to levels of key environmental stimuli. During a critical period in the Drosophila olfactory system, we found that exposure to ethyl butyrate (EB) induces glial phagocytosis of odorant receptor Or42a-positive olfactory sensory neuron (OSN) axon terminals which terminate in the VM7 glomerulus (Leier et al., 2025). Here, we extend these findings by establishing functional significance and circuit selectivity in this critical period paradigm. First, using a combination of two-p
- Europe PMC · Published · First archived
Tonoplast-Localized ABCC Transporters Enhance Heterologous Production of the Antidiabetic Montbretin A and Its Analogues in Nicotiana benthamiana. ↗
The plant-derived specialized metabolite montbretin A (MbA) is under development as an improved treatment for Type 2 diabetes, a worldwide epidemic. MbA is an acylated flavonol glycoside so far only found in small amounts in montbretia (Crocosmia × crocosmiiflora) corms. The compound's structural complexity and low natural abundance present major challenges for large-scale production. To enable the development of a scalable MbA production system, we have previously engineered Nicotiana benthamiana to produce MbA. In addition to low levels of MbA, N. benthamiana also produces the pharmaceutical
- Europe PMC · Published · First archived
Neuroprotective Effects of Nanocurcumin in Spinal Cord Injury: Modulation of Inflammatory and Inflammasome-Associated Signaling in an Integrated In Vivo , In Silico , and Machine-Learning Study. ↗
Spinal cord injury (SCI) triggers secondary neuroinflammatory and inflammasome-associated responses that contribute to tissue damage and functional impairment. This study evaluated nanocurcumin in experimental SCI using integrated experimental, computational, and exploratory machine-learning approaches. Adult male Wistar rats were allocated to Sham, SCI, or SCI + nanocurcumin groups. SCI was induced by T6 contusion, and nanocurcumin (50 mg/kg, intraperitoneally) was administered every 12 hours for 72 hours. Functional, histological, molecular, and inflammatory outcomes were assessed using BBB
- Europe PMC · Published · First archived
Genome-wide-scale prediction of compound-protein interactions using foundation and language models based on three-dimensional structures of compounds and proteins. ↗
Motivation The identification of compound-protein interactions (CPIs) is crucial in the early stages of drug discovery. However, machine-learning (ML)-based methods based on one- and two-dimensional representations cannot capture important geometric information on the binding sites of CPIs, which limits their predictive accuracy. Results We propose DESTIN (dual structure-guided estimation of substance-target interaction networks), an ML framework for CPI prediction on a genome-wide scale from the three-dimensional (3D) structures of compounds and proteins. We constructed compound feature vecto
- Europe PMC · Published · First archived
Genetic and cellular architecture of breast cancer risk across ancestries. ↗
Background Breast cancer genome-wide association studies (GWAS) have identified more than 200 susceptibility loci, but most studies are dominated by European and East Asian populations. Methods We analyzed breast cancer GWAS summary statistics from African (AFR), East Asian (EAS), European (EUR), and Hispanic/Latina (H/L) samples (159,297 cases and 212,102 controls). We estimated logit-scale SNP-based heritability, polygenicity, and cross-ancestry genetic correlation, partitioned heritability across functional annotations, and integrated GWAS results with the Tabula Sapiens single-cell atlas u
- Europe PMC · Published · First archived
Synbiotic supplementation may attenuate osteoporosis following spinal cord injury in a rat model. ↗
Context Spinal cord injury (SCI) often leads to severe bone loss and a higher risk of osteoporosis. Current treatments have not fully addressed bone deterioration, which remains a major clinical issue. New research suggests that the gut microbiota may influence bone health, and probiotics might help improve bone status. This study aimed to assess the effect of synbiotic supplementation, which combines probiotics and prebiotics, on bone health in a rat model of SCI-induced osteoporosis. Methods Male Wistar rats were randomly divided into three groups: control (sham), SCI, and SCI + synbiotic. S
- Europe PMC · Published · First archived
The acceptability of and adherence to a high-dose walking booster program after stroke (HiWalk): a multi-method study of stroke survivors' experiences nested within a randomised controlled trial. ↗
Purpose To evaluate the acceptability of a high-dose walking booster program for community-dwelling stroke survivors by examining adherence and identifying barriers and facilitators to participation. The program was a short duration, high-dose motor training program for walking, delivered up to three hours daily over three weeks. Materials and methods A multi-method study was conducted parallel to a Phase II randomised trial (HiWalk). Adherence to the program was measured using attendance and repetition counts. Nineteen participants from the experimental group were interviewed using a schedule
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How to assess evidence about Science
Check each original source for its methods, release status, limitations, and supporting data. A repository announcement, a preprint, and a published study provide different kinds of evidence. SYMTRI’s subject classification helps discovery; it does not independently validate the source’s claims.
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