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Earlier sources: Science
Science investigates the natural world through observation, experiments, and mathematical models. Explore papers and developments in biology, medicine, materials, neuroscience, physics, climate, and mathematics; a reported finding is not necessarily established consensus.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗1684 classified signals in the fourteen-day window. Recent momentum: steady. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- OpenAlex · Published · First archived
Fungal -omics resources and the challenges of function prediction toward unlocking the potential of enzyme biocatalysts ↗
Fungal enzymes represent a versatile and underexploited resource for sustainable industrial biocatalysis due to their extensive functional diversity and metabolic adaptability. Recent advances in multi-omics technologies, genome mining platforms, and enzyme classification systems have significantly enhanced the identification and annotation of fungal enzymes and biosynthetic gene clusters. However, current discovery pipelines remain constrained by limited integration across predictive genome mining tools, functional genomics resources, and experimentally validated enzyme and metabolite dataset…
- OpenAlex · Published · First archived
Perceived digital competence following virtual reality-supported physics learning in junior secondary schools ↗
Abstract Virtual reality-supported physics learning is increasingly recognized as a promising approach for strengthening both science understanding and digital competence in school settings. This study described students’ perceived digital competence after participation in virtual reality-supported solar system learning across four junior secondary schools. Using a quantitative post-intervention design, the study involved 144 students, with 36 students drawn from each school, who completed the 25-item Assessment of Digital Competence for Students (ADI-S), a self-report questionnaire covering o…
- OpenAlex · Published · First archived
Oncolytic virotherapy in cancer: cellular mechanisms, engineering strategies, and clinical translation ↗
Abstract Oncolytic viruses (OVs) combine tumour-selective infection and replication with direct tumour-cell destruction and the capacity to induce antitumour immune responses. This review critically synthesises the cellular mechanisms, engineering strategies, preclinical development, clinical translation, major limitations, and future directions of oncolytic virotherapy. A narrative synthesis was conducted using the mechanistic, preclinical, clinical, regulatory, and translational literature assembled in the source review. The evidence encompasses naturally occurring and genetically engineered…
- Europe PMC · Published · First archived
A hydrogen-producing mitochondrion in an anaerobic eukaryotrophic rhizarian ↗
Diverse eukaryotes thrive under low oxygen conditions, in part through highly modified mitochondrion-related organelles (MROs) that use alternate metabolic pathways to support ATP production and cofactor recycling. Anaerobic lifestyles have evolved repeatedly across the eukaryotic tree of life, each providing an independent opportunity to understand how eukaryotes adapt to life in low oxygen conditions. Here, we use single-cell transcriptomics to reconstruct the MRO metabolism of PCE SSF, a benthic eukaryotrophic flagellate and the first cultivated representative of Novel Clade 12 (NC12; Rhiza
- Europe PMC · Published · First archived
Temporal control of mitochondrial mutagenesis reveals the fate of mtDNA mutations with age ↗
Mutations in the mitochondrial genome (mtDNA) play a critical role in the aging process and a wide variety of age-related diseases. However, it remains unclear when the mutations that drive physiological decline arise. To answer this question, we generated a new mouse model in which mitochondrial mutagenesis can be confined to a defined window of time. Surprisingly, we found that mutations that arise during the first two months of life are sufficient to drive a wide variety of age-related pathologies, and that the severity of this pathology is broadly regulated by distinct, tissue-specific sel
- Europe PMC · Published · First archived
Genetic architecture of immune-mediated thrombotic thrombocytopenic purpura in Han Chinese individuals ↗
Thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening thrombotic microangiopathy caused by a severe deficiency of the ADAMTS13 protease. We performed the first large-scale genome-wide association study (GWAS) of TTP in 1,344 individuals of Han Chinese ancestry, comprising a discovery cohort (n = 913) and a validation cohort (n = 431). We identified two independent susceptibility loci, including the known locus 6p21 and the novel locus 14q32. At the known locus 6p21, the lead signal rs2187668 is near HLA-DQA1 and strongly associated with TTP risk (P = 5.35e-10; Odds Ratio [OR] =
- Europe PMC · Published · First archived
A founder population reveals genetic variation with major effect on serious mental illness ↗
Genetic studies of serious mental illness (SMI, including schizophrenia and bipolar disorder) have implicated two classes of risk variant: common variants 1–3 , each of small effect but collectively accounting for most population–level risk, and ultra–rare coding variants 4,5 which confer large risk in a small number of individuals. Most such studies cannot directly assess the impact of specific variants on SMI, transdiagnostically, as the phenotypic information that they collect is focused on a single diagnosis. Here we report results of association analysis of predicted deleterious variants
- Europe PMC · Published · First archived
Breaking the link between demyelination and axon loss: SARM1 inhibition as a neuroprotective strategy for multiple sclerosis ↗
Axonal degeneration is a principal driver of irreversible neurological disability in multiple sclerosis (MS), yet current treatments fail to target this neurodegenerative phase directly. Sterile alpha and TIR domain-containing protein 1 (SARM1) has emerged as an executioner of programmed axon destruction and is overexpressed in grey and white matter MS tissue, making its inhibition a promising therapeutic strategy. However, the effects of SARM1 inhibition on localized neurodegeneration versus systemic and central inflammation remain poorly understood in complex autoimmune environments like MS.
- Europe PMC · Published · First archived
Uncorrected publication bias distorts the spindle-memory link: Comment on Chen et al (2024) “Sleep spindles consolidate declarative memory with tags: A meta-analysis of adult data” ↗
The recent meta-analyis by Chen et al (2024) investigates the link between sleep spindles and the consolidation of tagged declarative memory traces and reports substantial publication bias. The present commentary discusses the significance of publication bias in the literature of the cognitive neuroscience of sleep spindles. Using the dataset published by the original authors, it is demonstrated that with adequate controls for publication bias, the link between sleep spindles and memory consolidation is greatly diminished or absent, in line with the pattern seen in other recent meta-analyses.
- Europe PMC · Published · First archived
Neuroscience-Informed Psychoeducation for Dementia ↗
Dementia is a progressive syndrome characterized by neurodegeneration across distributed brain networks that results in cognitive, behavioral, and functional declines. Conventional psychoeducation provides disease facts and resources but often lacks the mechanistic grounding needed to translate knowledge into durable caregiver skills. Neuroscience-informed psychoeducation (NIPE) extends traditional approaches by offering brain-based explanations of symptoms and caregiving challenges, paired with learning principles optimized for stressed learners. This chapter proposes a dementia-specific NIPE
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How to assess evidence about Science
Check each original source for its methods, release status, limitations, and supporting data. A repository announcement, a preprint, and a published study provide different kinds of evidence. SYMTRI’s subject classification helps discovery; it does not independently validate the source’s claims.
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