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Earlier sources: Science
Science investigates the natural world through observation, experiments, and mathematical models. Explore papers and developments in biology, medicine, materials, neuroscience, physics, climate, and mathematics; a reported finding is not necessarily established consensus.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗1675 classified signals in the fourteen-day window. Recent momentum: steady. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- arXiv · Published · First archived
Beyond NISQ Assumptions: One-time Memory in the Classically Accessible Random-Oracle Model ↗
Quantum information enables many cryptographic primitives that are impossible in the classical world. A line of works has developed cryptographic protocol under the assumption that quantum adversaries are restricted to noisy intermediate-scale quantum (NISQ) computing power, enabling strong one-time functionalities. But the advent of early fault-tolerant quantum computers eras will allow deeper logical quantum circuits, calling into questions the applicability of these NISQ-based assumptions. In this work, we adapt the classically accessible random oracle model (CAROM) as in [BDF+11] and [AK22…
- arXiv · Published · First archived
Spall Failure of Coral Skeleton beneath Gas-Laden Canopies: An Idealized Blast-Fishing Model ↗
Improvised explosives used for fishing on shallow Indonesian reefs shatter coral skeleton, yet the damage they cause has been described largely through empirical radii and ecological surveys. We formulate an idealized model of how free gas held within a coral canopy modifies the shock loading that such a charge delivers to skeletal plates. The canopy is treated as a relaxed bubbly mixture whose shock impedance follows from the conservation of mass and momentum, and the reef is represented as a layered column of water, canopy, skeletal plate, and canopy struck at normal incidence. Three closed-…
- OpenAlex · Published · First archived
Single‐Shot Simultaneous Recovery of Phase and Degree of Polarization in Multimode Fibers via Physics‐Constrained Global Attention ↗
ABSTRACT Concurrently recovering the vectorial optical field, including the spatial phase and degree of polarization at the distal end of a multimode fiber using interferometer‐free measurements remains an open challenge. Existing computational approaches typically retrieve phase or polarization separately, as jointly decoding both quantities from a single scalar measurement constitutes a highly ill‐posed. Here, we demonstrate single‐shot simultaneous reconstruction of phase and degree of polarization from a single non‐interferometric speckle intensity frame. A dual‐path spatial‐multiplexing s…
- OpenAlex · Published · First archived
Computational evaluation of novel hydantoin hydrazone hybrids as potential antimicrobial candidates against DNA gyrase and CYP51 ↗
Abstract Hydantoin hydrazone hybrids, including compounds 2 , 3a–d , 4a–b , 5a–b , and 6 , were computationally investigated as potential dual-target antimicrobial candidates using an integrated workflow comprising density functional theory (DFT), molecular docking, molecular dynamics (MD) simulations, and MM-PBSA binding free energy analysis. DFT calculations at the APFD/6-311 + + G(d, p) level in the gas phase and DMSO using the SMD solvation model revealed favorable solvation free energies ranging from − 94.84 to − 121.45 kJ/mol. Solvation increased the dipole moments and polarizabilities o…
- OpenAlex · Published · First archived
CRISPR-based gene drive systems alter the transcriptome in Anopheles gambiae mosquitoes ↗
CRISPR-based gene drive systems have emerged as promising strategies for mosquito population control to reduce the impact of vector-borne diseases such as malaria. However, their broader molecular impact on the mosquito transcriptome remains poorly understood. We performed an RNA sequencing analysis of Anopheles gambiae gene drive (GD) mosquitoes under three conditions: males fed with sugar, females fed with sugar, and females fed with blood. Principal component analyses identified sex and diet as the major drivers of transcriptomic variation, although differential expression analyses identifi…
- OpenAlex · Published · First archived
A Tularemia cluster in Manisa, Türkiye: clinical characteristics and investigation of a probable waterborne source ↗
Abstract Background Tularemia is a re-emerging zoonotic disease caused by Francisella tularensis. In Türkiye, water-associated transmission is an important epidemiological pattern and oropharyngeal disease is common. This study aimed to describe the clinical characteristics of a tularemia cluster identified in Manisa, western Türkiye, and to evaluate the epidemiological and environmental findings supporting a probable waterborne source. Methods This retrospective, observational, two-center study included 13 adult patients with clinically compatible tularemia and a single positive microagglutin…
- OpenAlex · Published · First archived
The genome sequence of Grey Alder, Alnus incana Moench, 1794 (Fagales: Betulaceae) ↗
We present a genome assembly of Alnus incana (Grey Alder; Streptophyta; Magnoliopsida; Fagales; Betulaceae). The assembly consists of two haplotypes with total lengths of 514.98 megabases and 520.08 megabases. Most of haplotype 1 (97.02%) is scaffolded into 14 chromosomal pseudomolecules. Haplotype 2 was assembled to scaffold level. The mitochondrial sequences have lengths of 505.31 and 154.63 kilobases and the plastid genome assembly has a length of 160.8 kilobases. This assembly was generated as part of the Darwin Tree of Life project, which produces reference genomes for eukaryotic species…
- OpenAlex · Published · First archived
CRISPR-dCas13a-based electrochemical biosensor for sensitive detection of miR-331-5p as a potential biomarker of Parkinson's disease ↗
This study aimed to develop a CRISPR-dCas13a-based electrochemical biosensor as a proof-of-concept analytical platform for the sensitive and selective detection of miR-331-5p, which has been reported to be associated with Parkinson's disease. The biosensor was prepared by sequentially forming a self-assembled monolayer with 11-mercaptoundecanoic acid (MUA) on a gold electrode, functionalizing the surface with a generation-4 polyamidoamine (PAMAM-G4) dendrimer, immobilizing dCas13a, and assembling the target-specific sgRNA recognition complex. The electrode-modification steps were evaluated usi…
- OpenAlex · Published · First archived
Genome-wide variant atlas of cucumber sex determination reveals line-specific molecular networks as a candidate resource for cucumber breeding ↗
Abstract Background Sex determination in cucumber ( Cucumis sativus L.) shapes yield, hybrid-seed production and breeding efficiency, yet most genomic studies have focused on single phenotypes or individual loci. A broader, integrative genomic comparison of cucumber lines representing contrasting sexual phenotypes is still lacking. Results We generated > 20 million 100-bp paired-end reads for each of five lines that represent a broad spectrum of contrasting cucumber sexual phenotypes - male (859), recessive gynoecious (2gg), dominant gynoecious (Gy3) and two independent hermaphrodites (2667, H…
- OpenAlex · Published · First archived
Engineering a compact CgCas12n platform for efficient genome and base editing in mammalian cells ↗
Type V CRISPR-Cas12 systems evolved from transposon-encoded TnpB proteins, with type V-U4 nucleases (Cas12n) as evolutionary intermediates linking TnpB to larger type V effectors. Despite their compact size, most Cas12n orthologs, including Corynebacterium glutamicum Cas12n (CgCas12n), exhibit low genome-editing activity in mammalian cells. Here, we engineered CgCas12n using an arginine enrichment strategy, generating a variant with approximately 60-fold enhanced editing efficiency. Concurrently, we optimized the sgRNA scaffold to reduce its size without compromising activity. These improvemen…
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