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Earlier sources: Science
Science investigates the natural world through observation, experiments, and mathematical models. Explore papers and developments in biology, medicine, materials, neuroscience, physics, climate, and mathematics; a reported finding is not necessarily established consensus.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗1682 classified signals in the fourteen-day window. Recent momentum: steady. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- OpenAlex · Published · First archived
Diet, Obesity and Cardiovascular Health: Molecular Mechanisms, Clinical Evidence and Future Perspectives ↗
Background: Obesity and unhealthy dietary habits are among the leading modifiable determinants of cardiovascular disease, acting through biological mechanisms that extend far beyond excess body weight. Adipose tissue dysfunction, chronic low-grade inflammation, oxidative stress, endothelial impairment, mitochondrial dysfunction, and gut microbiota dysbiosis contribute to the development and progression of cardiometabolic disease. Consequently, nutrition should be regarded as a key biological modulator of cardiovascular risk, capable of influencing multiple interconnected metabolic and molecula…
- OpenAlex · Published · First archived
The GrimAge clock corresponds to brain ageing and social determinants of health in people with HIV ↗
BACKGROUND: DNA methylation (DNAm)-based epigenetic clocks can measure biological ageing. However, newer epigenetic clocks sensitive to morbidity, mortality, and longitudinal change have not been compared to brain health biomarkers in virally suppressed people with HIV (PWH) and without HIV (PWoH). METHODS: Participants in this case-control study underwent blood draws, brain MRI, and neuropsychological testing. Four DNAm-based epigenetic clocks were calculated: GrimAge (mortality-predictive), PhenoAge (morbidity-sensitive), DunedinPACE (longitudinal), and DNAm telomere length. Clocks were corr…
- OpenAlex · Published · First archived
Shield strike shatter in DNA topology and nuclease interactions ↗
DNA degradation by nucleases is central to genome maintenance, immune defense, and the clearance of extracellular DNA, yet its execution at the single-molecule level remains poorly defined. Here, we use high-speed atomic force microscopy (HS-AFM) to directly visualize the real-time dynamics of DNA digestion by DNase I at nanometer resolution. DNase I repeatedly revisits structurally strained DNA regions before cleavage initiation, revealing a topology-sensitive mode of interaction that is inaccessible to ensemble biochemical approaches. Time-resolved imaging further uncovers a multistep degrad…
- OpenAlex · Published · First archived
High-Intensity Focused Ultrasound Technology: Physical Principles, Biological Effects, and Clinical Applications in Facial and Neck Rejuvenation ↗
High-Intensity Focused Ultrasound (HIFU) has emerged as a revolutionary non-invasive technology in aesthetic medicine, enabling targeted tissue remodelling and skin rejuvenation through precise thermal and mechanical effects. This narrative review provides a comprehensive examination of the physical foundations of HIFU, including acoustic wave propagation, piezoelectric energy conversion, and transducer design. It also explores its biological mechanisms, including collagen denaturation, neocollagenesis, fibroblast activation, and extracellular matrix remodelling. Clinically, HIFU has shown sig…
- OpenAlex · Published · First archived
A Batch-Aware, Subject-Grouped Pipeline to Prioritize HIIT-Associated DNA Methylation Candidates with Cross-Cohort Evaluation in Skeletal Muscle ↗
Skeletal muscle DNA methylation is closely associated with molecular adaptation to exercise training, but longitudinal studies in this area are constrained by the difficulty of repeated muscle biopsy sampling and extended follow-up. The resulting datasets are typically small, with repeated measurements within individuals and complex sub-cohort or batch structure. To address these limitations, we developed a methylation candidate-discovery pipeline that integrates batch-aware statistical screening, subject-grouped nested cross-validation, and a binary/multi-class/temporal three-axis consensus s…
- OpenAlex · Published · First archived
Operator-Budget Evaluation of Residual-Adaptive Sampling in Physics-Informed Neural Networks ↗
Residual-adaptive collocation is commonly compared at equal optimizer steps, although maintaining its sampling proposal requires PDE-residual evaluations in addition to those used for training. Such comparisons can obscure whether an apparent gain comes from point placement or from additional information work. We introduce an operator-budget evaluation framework that records training and proposal-maintenance residual calls in a common ledger, distinguishes fixed-update cost from work-matched accuracy, and requires a joint cost–accuracy decision. Amortized residual proposal maintenance (ARPM) s…
- OpenAlex · Published · First archived
GenPTM: a generalizable framework for protein post-translational modification information extraction from the scientific literature ↗
Abstract Background Protein post-translational modification (PTM) plays a pivotal role in cellular activities and biological processes. Although several databases curate PTM information, most cover only a limited number of PTMs. Although the scientific literature continues to accumulate a vast amount of PTM-related knowledge, these databases are not updated regularly. This growing information gap highlights the need for automated information extraction (IE) systems that can identify modified proteins and their specific amino acid sites directly from the literature. While numerous PTMs have bee…
- OpenAlex · Published · First archived
Uncovering potential autotrophs in coal seams: characterization, enrichment, and genome-resolved metabolisms of a subsurface coal seam microbiome ↗
ABSTRACT Biological transformation of inorganic carbon into organic compounds is an extremely important biosynthetic process, and many organisms catalyze this reaction autotrophically, using CO 2 as the sole carbon source. Natural autotrophic pathways are diverse, as are the organisms that employ them, driven in part by the varied ecological niches they inhabit. One understudied ecological niche, coal seams, contains autotrophic acetogens that catalyze an intermediate step in the conversion of coal to methane. Here, we characterize the geochemistry and microbiology of coal seam produced water…
- OpenAlex · Published · First archived
A Macro-Anchored Physics-Informed GAN for RUL Prediction Under Continuous Block Missing Data ↗
Continuous block missingness in condition monitoring data poses a major challenge to the reliability of Remaining Useful Life (RUL) prediction for industrial equipment. Existing frameworks, including direct prediction from incomplete observations and decoupled two-stage imputation–prediction pipelines, suffer from a noticeable performance decline under prolonged data voids. Although Generative Adversarial Network (GAN)-based generative models have shown promise in data repair, they remain limited by dimensionality contamination from fixed-dimension architectures, purely data-driven over-smooth…
- OpenAlex · Published · First archived
An optimized nanopore-based bioinformatic pipeline for PKD1 variant detection: development and validation with clinical samples ↗
Abstract Background Accurate variant detection in PKD1 , the primary causative gene of autosomal dominant polycystic kidney disease (ADPKD), requires long-range PCR (LR-PCR) strategies to selectively amplify the functional gene and circumvent interference from highly homologous pseudogenes. Oxford Nanopore Technology (ONT) offers a cost-accessible sequencing alternative to short-read platforms, with particular relevance for clinical implementation in public health systems and low-resource settings. However, ONT data are characterized by higher error rates compared to Illumina sequencing, makin…
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How to assess evidence about Science
Check each original source for its methods, release status, limitations, and supporting data. A repository announcement, a preprint, and a published study provide different kinds of evidence. SYMTRI’s subject classification helps discovery; it does not independently validate the source’s claims.
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