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Earlier sources: Science
Science investigates the natural world through observation, experiments, and mathematical models. Explore papers and developments in biology, medicine, materials, neuroscience, physics, climate, and mathematics; a reported finding is not necessarily established consensus.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗1706 classified signals in the fourteen-day window. Recent momentum: steady. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- OpenAlex · Published · First archived
Adaptive evolution of cancer-associated extrachromosomal DNA under therapeutic pressure: origin attribution, structural remodeling, mechanisms of acquired resistance, and therapeutic implications ↗
Cancer-associated extrachromosomal DNA (ecDNA) increases intratumoral heterogeneity through non-Mendelian inheritance, high-copy-number oncogene amplification, and structural plasticity, thereby facilitating clonal selection under therapeutic pressure. Following chemotherapy or molecularly targeted therapy, ecDNA may undergo copy-number gain or loss, transient loss and re-emergence after treatment withdrawal, structural remodeling, and switching of amplification topology between extrachromosomal and intrachromosomal forms. These changes may reflect selection of pre-existing low-frequency ecDNA…
- OpenAlex · Published · First archived
Physics-Guided Dual-Branch Domain Generalization with Confidence-Adaptive Decision Fusion for Cross-Speed Fault Diagnosis of Planetary Gearboxes ↗
Data distribution shift across different rotational speeds limits domain generalized fault diagnosis for planetary gearboxes. Existing single-representation domain generalization (DG) methods degrade severely in cross-speed extrapolation, with different representations showing speed-dependent advantages. The core contribution of this paper is a sample-wise confidence-adaptive decision fusion mechanism under the pure DG constraint. For each test sample, the fusion weights are computed online from the relative softmax prediction confidence of the two branches. The mechanism requires neither targ…
- OpenAlex · Published · First archived
Multi-graph interactive oil production prediction network integrating physics priors and data-driven approaches ↗
Abstract In the digital transformation of smart oilfields, accurate oil production prediction is essential for optimizing production strategies. However, the production process is a complex nonlinear system involving coupled electrical, fluid, and thermodynamic domains where sensor data is high-dimensional and noisy. Traditional mechanistic models struggle with parameter calibration, while standard data-driven models like LSTM often overlook spatial topological relationships and physical constraints. To address these challenges, this paper proposes the multi-graph interaction learning network…
- OpenAlex · Published · First archived
MicroRNAs in Cutaneous Melanoma: Biological Roles, Clinical Utility, and Future Directions ↗
Cutaneous melanoma remains a malignancy with substantial metastatic potential, and conventional diagnostic and surveillance tools such as biopsy and imaging have recognized limitations in sensitivity, specificity, and invasiveness. Circulating microRNAs (miRNAs) have emerged as promising non-invasive biomarkers because of their stability in body fluids and their disease-specific expression patterns. This narrative review summarizes current evidence on the biological roles of miRNAs in melanoma, acting as either oncogenes or tumor suppressors, and their potential clinical utility across diagnos…
- OpenAlex · Published · First archived
Comprehensive Evaluation of Gastrointestinal Factors Influencing the Stability and Function of mRNA‐Encapsulated Lipid Nanoparticles ↗
Owing to the intrinsic instability of mRNA, its routes of administration are limited, and to date, only injectable delivery has been clinically applied. In contrast, oral administration exposes mRNA to a variety of substances in the gastrointestinal (GI) tract. Despite these challenges, oral delivery remains the most familiar and convenient route for patients, making the development of orally administrable mRNA-encapsulated lipid nanoparticles (mRNA-LNPs) highly desirable. However, no studies have directly examined how mRNA-LNPs are affected within the GI environment. In the present study, we…
- OpenAlex · Published · First archived
Effective Sequence-to-Expression Prediction for a Model Membrane Protein Using Machine Learning and Computational Protein Design ↗
Abstract The recombinant expression of integral membrane proteins is notoriously challenging. One way to address this challenge is via computational genotype-to-phenotype models that determine how particular sequence features correlate with protein expression levels. However, the potential of such approaches is yet to be fully realized, at least partly because so few expression datasets are available. Here, we study the sequence-to-expression relationships of a variant library originally derived from combinatorial computational design. The controlled sequence diversity of this library makes th…
- OpenAlex · Published · First archived
Mission-Profile-Aware Physics-of-Failure Reliability Assessment and Quantitative FMEA of a 10 kW Solid-State Transformer ↗
Solid-state transformers (SSTs) are pivotal for next-generation power systems, yet their widespread adoption is hindered by reliability uncertainties under diverse operational conditions. This paper introduces a mission-profile-aware, physics-of-failure (PoF) reliability assessment framework that explicitly links operating conditions, degradation mechanisms, and statistical uncertainty. The approach combines PoF models for stress-sensitive components with handbook-based reliability models for passive elements, employing Joint Electron Device Engineering Council (JEDEC)-aligned statistical meth…
- OpenAlex · Published · First archived
Distribution of Escherichia coli Pathotypes in Poultry by Host, Clinical Relevance, and Serogroup ↗
Escherichia coli (E. coli) infections in poultry represent a significant disease burden, causing economic losses and posing public health risks due to their zoonotic potential. Although E. coli is generally characterized by low host specificity, the genetic diversity and acquisition of virulence factors enable the emergence of distinct pathotypes associated with different disease outcomes. In this review, the global and Türkiye-specific distribution of poultry-associated E. coli pathotypes was evaluated in terms of host species, clinical relevance, and serogroup diversity. The most frequently…
- OpenAlex · Published · First archived
Standardising embodied diagnostic knowledge: pulse diagnosis terminology in WHO Chinese medicine standards ↗
Pulse diagnosis is a culturally embedded form of medical knowledge in Chinese medicine, combining tactile experience, diagnostic judgement, and conceptual classification. When such knowledge is represented in international terminology standards, translation is not only a linguistic matter but also a process of conceptual standardisation. This study examines how English renderings of Chinese pulse diagnosis terminology are revised across two World Health Organization (WHO) terminology standards. The study compared 49 Chinese pulse diagnosis terms shared by the 2007 International Standard Termin…
- OpenAlex · Published · First archived
The complete chloroplast genome sequence and phylogenetic analysis of Zinnia elegans Jacq. 1792 (Asteraceae) ↗
The complete chloroplast genome of Zinnia elegans Jacq. 1792 was sequenced, assembled, and annotated. The 151,933-bp circular genome comprised an 83,124-bp large single-copy region, an 18,601-bp small single-copy region, and two 25,104-bp inverted repeat regions; its overall GC content was 37.48%. The finalized annotation contained 132 gene copies, including 87 protein-coding, 37 tRNA, and eight rRNA gene copies. Comparative analyses identified conserved genome organization and localized sequence-divergence hotspots . A maximum-likelihood analysis of 79 shared chloroplast protein-coding genes…
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Check each original source for its methods, release status, limitations, and supporting data. A repository announcement, a preprint, and a published study provide different kinds of evidence. SYMTRI’s subject classification helps discovery; it does not independently validate the source’s claims.
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