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Earlier sources: Science
Science investigates the natural world through observation, experiments, and mathematical models. Explore papers and developments in biology, medicine, materials, neuroscience, physics, climate, and mathematics; a reported finding is not necessarily established consensus.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗1706 classified signals in the fourteen-day window. Recent momentum: steady. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- OpenAlex · Published · First archived
From Closed to Mighty: How GTP-Induced Allosteric Dynamics, Dimerization, and Membrane Binding Transform a Bacterial Dynamin-like Protein ↗
Abstract Dynamins, crucial GTPases involved in membrane remodeling, play key roles in processes like endocytosis and membrane fission. While their importance is well-established, the precise dynamics of their conformational changes remain unclear. This study investigates the bacterial dynamin-like protein (BDLP) from Nostoc punctiforme, which undergoes a dramatic closed-to-open transition upon GTP binding. Using standard and enhanced all-atom molecular dynamics simulations, we map this transition, revealing a complex energetic landscape. The initial barrier arises from disruption of salt bridg…
- OpenAlex · Published · First archived
Long non-coding RNAs in tuberculosis: Immune regulation and clinical biomarker potential ↗
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains the leading infectious cause of mortality worldwide, with an estimated 1.25 million deaths in 2023. Despite therapeutic advances, the lack of precise early screening tools continues to impede epidemic control. Long non-coding RNAs (lncRNAs) have emerged as essential modulators of host anti-Mtb immunity, and elucidating their functional mechanisms is pivotal for developing effective interventions. This review systematically synthesizes lncRNA-mediated immune regulation during Mtb infection, with emphasis on their roles in mo…
- OpenAlex · Published · First archived
Integrated lncRNA and mRNA Transcriptome Analysis Reveals Candidate Regulatory Networks Associated with Postnatal Longissimus Dorsi Muscle Development in Hanper Sheep ↗
Skeletal muscle development is a key determinant of meat production and meat-quality traits in sheep, but the coordinated long non-coding RNA (lncRNA) and messenger RNA (mRNA) co-expression landscape underlying postnatal muscle development in Hanper sheep remains unclear. In this study, RNA sequencing was performed on Longissimus Dorsi muscle samples from Hanper sheep at 1 month (M1), 7 months (M7), and 13 months (M13) of age to characterize lncRNA and mRNA expression profiles during postnatal growth. A total of 13,940 candidate lncRNAs were identified, and these lncRNAs exhibited typical stru…
- OpenAlex · Published · First archived
Designing an mRNA vaccine encoding multi-epitopes to combat Pipistrellus bat coronavirus BtHKU5-CoV-2 based on consensus sequence using an immunoinformatics approach ↗
The bat-derived Pipistrellus bat coronavirus BtHKU5-CoV-2, a merbecovirus lineage, is an emerging zoonotic risk due to its ability to utilize human ACE2 receptors and ongoing spike protein recombination events that enhance cross-species transmission potential. At the moment no authorized vaccines are available against this emerging threat which emphasizes the urgent need for proactive vaccine development. This study employed reverse vaccinology and immunoinformatics approaches to design a novel mRNA vaccine candidate encoding multiple epitopes, aiming at conserved regions across four structura…
- OpenAlex · Published · First archived
Fully Complementary Interactions of Human mRNA Genes with miRNAs from NCBI Database ↗
miRNA has been studied for over 30 years, but the interaction of miRNA with mRNA has not been sufficiently studied to date. Problems in this area of research include the lack of adequate methods for predicting the characteristics of miRNA-mRNA interactions, and wet lab experiments are many times more labor-intensive and time-consuming. The aim of this study was to determine the characteristics of fully complementary interactions of miRNAs from the 2568 miRNAs of the NCBI database with mRNAs of 17,508 protein-coding genes using the MirTarget program. It was found that mRNAs from 384 genes have…
- OpenAlex · Published · First archived
Single-nucleus transcriptome-wide association study of human brain disorders ↗
Abstract Common brain disorders impose a substantial health burden, but localizing their genetic risk in the brain remains challenging 1 . Although genome-wide association studies have identified numerous loci associated with neuropsychiatric and neurodegenerative disorders, many of these loci lie in non-coding regions that influence gene expression in specific cell types 2–5 . Traditional bulk brain transcriptomic analyses, which often focus on European ancestry cohorts, average over cellular diversity, obscuring genetic risk-related changes in gene expression. Here we use single-nucleus gene…
- OpenAlex · Published · First archived
Peptide-Based Molecular Glues for Targeted Protein Degradation ↗
Targeted protein degradation has transformed drug discovery by replacing occupancy-driven inhibition with event-driven removal of disease-causing proteins, opening previously “undruggable” targets, including transcription factors, scaffolding proteins, and intrinsically disordered regions, to therapeutic intervention. Within this landscape, peptide-based molecular glues have emerged as a distinct and underexplored modality, combining the extended, adaptable interaction surfaces of peptides with the mechanistic simplicity of induced-proximity pharmacology. Unlike bifunctional degraders such as…
- OpenAlex · Published · First archived
Complete Genome Sequence of Lysinibacillus xylanilyticus PK6, Isolated from Soybean Rhizosphere Soil in a Nitrogen-Deficient Field ↗
The genus Lysinibacillus (family Caryophanaceae, phylum Bacillota) comprises Gram-positive, spore-forming, rod-shaped bacteria that are widely distributed in soil and the plant rhizosphere, where several members display plant growth-promoting and biocontrol activities [1].Lysinibacillus xylanilyticus was originally described as a xylan-degrading bacterium isolated from forest humus [2].Here we report the complete genome sequence of strain PK6, its taxonomic assignment, its plant-beneficial gene content and a preliminary genomebased safety screen relevant to its use as a rhizosphere inoculant.S…
- OpenAlex · Published · First archived
Prevalence of carbapenem-resistant Klebsiella pneumoniae and associated carbapenemase genes among clinical isolates in Iran: a systematic review and meta-analysis ↗
Background Carbapenem-resistant Klebsiella pneumoniae (CRKP) has emerged as a major global public health threat due to limited treatment options and high morbidity and mortality. This systematic review and meta-analysis aimed to estimate the pooled prevalence of CRKP among clinical isolates in Iran based on studies incorporating molecular detection of carbapenemase-encoding genes and to characterize the distribution of major carbapenemase-encoding genes among clinical isolates. Methods Relevant studies conducted in Iran and involving clinical K. pneumoniae isolates obtained from human patients…
- OpenAlex · Published · First archived
Mechanics of electroadhesion by polycation interfacial bridging: sticky electrophoresis, ionic complexation and chain entanglement ↗
Abstract An e-GLUE is a polymer network containing interpenetrating polycations, which can bond the anionic network of mucosa by polycation interfacial bridging under an electric field. This paper formulates a theoretical model to study such electroadhesion by electrophoresis of polycations, ionic complexation between polycations and the anionic network, and polycation-network entanglement. We use a diffusion- drift model coupled with a Bell-like field-dependent chain friction to describe the sticky electrophoresis of polycations in the anionic network. We determine the formation of ionic bond…
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