THE INTERNET IS THINKING
Earlier sources: Science
Science investigates the natural world through observation, experiments, and mathematical models. Explore papers and developments in biology, medicine, materials, neuroscience, physics, climate, and mathematics; a reported finding is not necessarily established consensus.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗1709 classified signals in the fourteen-day window. Recent momentum: steady. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- Europe PMC · Published · First archived
Real-World Therapeutic Use of Ketamine in Clinical and Non-Clinical Settings: A Cross-Sectional Survey. ↗
The use of ketamine as a treatment for mood disorders continues to grow in popularity. However, the differences between individuals consuming ketamine within clinical settings and those self-medicating in casual, non-clinical settings has not been yet characterized. Using the 2023 Global Psychedelic Survey, this study aimed to examine the demographic and clinical characteristics, as well as the self-reported effectiveness and hallucination-related side effects, of ketamine use by comparing individuals using ketamine with and without medical supervision. Compared to clinical ketamine consumers
- Europe PMC · Published · First archived
Genome-Wide DNA Methylation Profiling in Patients with Hypertension and Asymptomatic Intracranial Atherosclerotic Stenosis. ↗
Background Hypertension is a major risk factor for intracranial atherosclerotic stenosis (ICAS), a leading cause of ischemic stroke in Asian populations. However, conventional risk factors only partially account for the pathogenesis of ICAS, underscoring the potential roles of epigenetic mechanisms. Methods We performed genome-wide DNA methylation profiling of 218 Chinese patients with hypertension using an Illumina Infinium Methylation EPIC 850K BeadChip. Identified differentially methylated positions (DMPs) were validated via pyrosequencing in 281 patients without asymptomatic ICAS (aICAS) w
- Europe PMC · Published · First archived
A probiotic Bifidobacterium pseudocatenulatum converts hesperidin to bioactive hesperetin and improves metabolic dysfunction in aging mice. ↗
Dietary flavonoids often require microbial metabolism to generate bioactive metabolites that influence host physiology. Hesperidin, a citrus flavanone glycoside, exhibits limited intestinal absorption and depends on gut microbial biotransformation to yield its active aglycone, hesperetin. Hesperetin activates CDGSH iron-sulfur domain 2 (CISD2), a pro-longevity gene whose expression declines with age, and its pharmacological activation has emerged as a strategy to promote healthy aging. Here, we identified a probiotic strain, Bifidobacterium pseudocatenulatum CL256B, that efficiently converts h
- Europe PMC · Published · First archived
Diminished Positive Affect as an Understudied Feature of Nicotine Withdrawal: Development and Validation of a Short Withdrawal Symptom Scale (SWiSS). ↗
Introduction Given the burgeoning evidence that low positive affect (PA) and anhedonia are important smoking withdrawal symptoms, we added the PA/Friendly items of the Profile of Mood States (POMS) alongside established withdrawal items from the Shiffman-Jarvik Withdrawal Questionnaire (SJWQ) to identify the best subsets of items for predicting smoking relapse. The Short Withdrawal Symptom Scale (SWiSS) was generated from these selected items. Methods Secondary data analysis was conducted with four randomized clinical trials of cessation-seeking smokers (N = 333) who maintained abstinence for
- Europe PMC · Published · First archived
Periodontitis, Edentulism, and Accelerated Biological Aging: A Population-Based Study of Epigenetic Clocks. ↗
Aim To examine whether periodontitis and its ultimate sequela (edentulism) are associated with accelerated epigenetic aging in older adults. Methods A total of 1 926 adults aged ≥ 50 years with DNA-methylation (DNAm) and oral health data from the NHANES 1999-2002 cycles were included. Periodontitis (stages/grades) and edentulism were classified using the 2018 AAP/EFP framework via the ACES system. Epigenetic age acceleration was estimated using genome-wide DNAm for four clocks: HannumAge, HorvathAge, PhenoAge, and GrimAge2Mort. Survey-weighted linear regression models, adjusted for relevant co
- Europe PMC · Published · First archived
Molecular characteristics of KPC-producing Klebsiella pneumoniae isolates from children and adults in Kunming. ↗
The increasing prevalence of KPC-producing Klebsiella pneumoniae (KPC-Kp) poses a critical public health threat. While Sequence Type 11 (ST11) is the dominant carbapenem-resistant clone in China, the comparative molecular characteristics of isolates affecting distinct patient demographics remain understudied. Fifty non-duplicate KPC-Kp clinical isolates (18 from children, 32 from adults) were prospectively collected from four hospitals in Kunming during 2023. Whole-genome sequencing was performed to determine multilocus sequence types (MLST), capsular serotypes (KL types), plasmid replicons, a
- Europe PMC · Published · First archived
A comprehensive report on the 1st Swiss-EUCAST Antimicrobial Susceptibility Testing (AST) Meeting. ↗
Antimicrobial susceptibility testing (AST) is being reshaped by increasingly complex resistance mechanisms, revised interpretive frameworks, and rapid phenotypic and genomic technologies. The first Swiss-EUCAST AST Meeting, held in Zurich on 4 May 2026, brought together more than 100 clinical microbiologists, researchers, and infectious diseases specialists to discuss how these developments should be translated into routine diagnostics. The meeting focused on three topics: the limitations of genotype-phenotype prediction, the ongoing need for standardized interpretation within the European Com
- Europe PMC · Published · First archived
Disentangling local adaptation and phenotypic plasticity in traits associated with altitude and temperature in widespread tropical butterflies. ↗
Climatic stratifications, in particular differences in temperature, occur along altitudinal clines. Understanding divergence across these regions can give insight into speciation and diversification, as well as how species may respond to climate change scenarios. Most past research has focused on temperate regions, yet year-round stable temperatures in the tropics make altitudinal temperature variation more pronounced and increase the likelihood of local adaptation across relatively narrow gradients. Here we investigate how genetics and the environment influence a wide range of traits in two w
- Europe PMC · Published · First archived
Genomic and functional divergence analysis of closely related Teseptimavirus phages reveals dual HNH endonuclease positioning and its role in plaque formation. ↗
Antibiotic resistance has renewed interest in bacteriophages as antimicrobials, yet the complexity of phage-host interactions often leads to inconsistent infection outcomes, underscoring the need to unravel the molecular basis of phenotypic diversity among closely related phages. Here, we compared two closely related T7-like phages, polyvalent phages C5 and N30, both belonging to Teseptimavirus , which share 89.67% genomic identity and an identical host range. While C5 exhibited a higher adsorption rate, plaque size, and efficiency of plating, N30 showed stronger bacteriostatic activity and la
- Europe PMC · Published · First archived
Identification and characterization of the hydratase ThnL preparing for the second-ring cleavage in anaerobic naphthalene degradation. ↗
Anaerobic degradation of polycyclic aromatic hydrocarbons (PAHs) proceeds through CoA-activated intermediates and β-oxidation-like reactions; however, the enzymes responsible for key hydration and hydrolytic steps remain insufficiently defined. In the sulfate-reducing enrichment culture N47, the thn operon encodes multiple putative hydratases and hydrolases proposed to participate in anaerobic naphthalene degradation. Here, we cloned, heterologously expressed, and purified six candidate enzymes (ThnA, ThnH, ThnI, ThnL, ThnM, and ThnU) to elucidate their substrate specificities. Among them, Thn
Live window recorded . This is the ingestion observation time, not the publication or discovery date of each source.
How to assess evidence about Science
Check each original source for its methods, release status, limitations, and supporting data. A repository announcement, a preprint, and a published study provide different kinds of evidence. SYMTRI’s subject classification helps discovery; it does not independently validate the source’s claims.
See the collection and counting methodology ↗ · Read the weekly synthesis ↗
Follow a thread
Explore related regions
These navigation suggestions are part of the map’s editorial structure, rather than measured evidence of a connection.