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Earlier sources: Neuroscience
This science thread follows neuroscience through original research, public projects, and source reports. Read the evidence below to see which developments are represented in SYMTRI’s archive.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗24 classified signals in the fourteen-day window. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- Europe PMC · Published · First archived
Increased CCR2-immunopositive myeloid cells in the putamen and cerebellar white matter with blood-brain barrier disruption in multiple system atrophy. ↗
Multiple system atrophy (MSA) is a progressive neurodegenerative disease characterized by parkinsonism, cerebellar ataxia, and autonomic dysfunction. Recently, a close relationship of neuroinflammation to MSA pathogenesis was identified. Studies in mouse models of MSA have indicated that peripheral-type myeloid cells and endogenous microglia promote neuroinflammation in MSA. However, their distinct roles in MSA pathogenesis remain unknown. We performed immunohistochemical analyses of brain tissues obtained at autopsy from patients with MSA and age-matched controls to examine the putamen and ce
- Europe PMC · Published · First archived
Centrally administered SGLT2 inhibitor improves gut barrier function through the brain orexin, AMPK, dopamine D2 signaling and the vagal pathway in rats. ↗
Leaky gut, defined as increased intestinal permeability, has been associated with many diseases. Recent studies suggest the brain is involved in maintaining gut barrier function. Since tofogliflozin, a sodium/glucose cotransporter 2 (SGLT2) inhibitor acts centrally to increase food intake, and feeding and gut functions are deeply associated, this study aimed to clarify the hypothesis that gut barrier function is influenced by centrally administered SGLT2 inhibitors in rats using Evans blue method. Intracisternal SGLT2 inhibitor blocked colonic hyperpermeability in response to lipopolysaccharid
- OpenAlex · Published · First archived
Sex-dependent cerebral inflammatory responses underlie sepsis-associated encephalopathy with altered brain oxylipin metabolism ↗
Sepsis-associated encephalopathy (SAE) is a common complication of sepsis with significant sex dimorphism, yet the underlying mechanisms remain unclear. Oxylipin signaling plays a crucial role in neuroinflammation, but how sex modulates cerebral oxylipin profiles during sepsis has not been systematically explored. Sepsis was induced in male and female C57BL/6 mice via cecal ligation and puncture (CLP). Targeted oxylipin metabolomics of brain tissue was performed 24 h post-CLP using LC-MS/MS. Protein expression of key enzymes and transporters was analyzed by western blot and immunofluorescence;…
- Europe PMC · Published · First archived
Take it personally: Promoting a personalised neuroscience informed approach to cognitive rehabilitation following psychopathology. ↗
People suffering from schizophrenia, depression and other severe mental illnesses often suffer from cognitive problems. In most people, these problems persists after the major symptomatic episode is over, and in some cases cognitive problems also preceded an episode. Unfortunately, even after symptomatic remission, full recovery of cognitive functions often does not occur, thereby severely and enduringly impeding daily life functioning. Although it’s recognized in the field of psychiatry and psychology that these cognitive problems persist, there is little mechanistic understanding of how thes
- Europe PMC · Published · First archived
Establishment of a human pluripotent stem cell-derived sensory neuron platform for studying diabetes-associated metabolic and oxidative stress-induced neuronal injury. ↗
Diabetic peripheral neuropathy (DPN) lacks effective disease-modifying therapies, partly due to the limited availability of standardized human-relevant in vitro models. Human pluripotent stem cell (hPSC)-derived sensory neurons provide a potential platform for investigating human neuronal vulnerability under diabetes-associated stress conditions and evaluating neuroprotective strategies. In this study, we established an hPSC-derived sensory neuron-enriched platform to model diabetes-associated neuronal stress. Human PSCs were differentiated into sensory neuron-enriched cultures characterized b
- Europe PMC · Published · First archived
From "neural activity" to "neural activities": a metabolic framework cultivates an integrative neuroscience by forcing a reexamination of foundational assumptions. ↗
Haueis and Colaço avoid referencing "neural activity," instead of speaking "neural activities". This subtlety speaks to a strength of their framework: Their metabolically oriented account helps bypass abstractions and stimulus-response assumptions endemic to traditional neuroscience paradigms. We highlight two advantages of this pivot to "neural activities," and how they pave the way for a unified, metabolically grounded, systems neuroscience.
- Europe PMC · Published · First archived
International Modified Delphi Consensus on Assessment and Management of Covert Brain Infarction. ↗
BackgroundCovert brain infarction (CBI) is a frequent incidental neuroradiological finding increasingly recognized as clinically relevant due to its association with stroke, cognitive decline, and other adverse outcomes. However, substantial uncertainty remains regarding its optimal assessment and management, and existing guidelines provide limited and heterogeneous recommendations. We aimed to develop an international expert consensus on the evaluation and management of CBI using a modified Delphi methodology.MethodsA modified Delphi process was conducted with an international, multidisciplin
- arXiv · Published · First archived
MIRTO: a registration-gated, multiverse-tested evaluation protocol for unsupervised anomaly segmentation in brain MRI ↗
Unsupervised anomaly detection (UAD) methods for brain MRI are ranked by a single score, yet that score rests on choices that are rarely reported: how each anomaly map is aligned with the reference, how and on which data the threshold is set, and which false-positive budget, metric, aggregation and lesion definition are used. We present MIRTO, an evaluation protocol that makes these choices explicit and measures their effect. It gates the geometry of every comparison with a registration check and label-free diagnostics of known power, sets thresholds on validation data alone and reports the fa…
- OpenAlex · Published · First archived
Dosimetric analysis of CT/MRI-based target delineation differences in radiotherapy for brain metastases close to the skull ↗
To quantify the dosimetric differences associated with CT/MRI-based target delineation in radiotherapy for brain metastases close to the skull (BMCS), and to provide dosimetric evidence for target delineation and treatment-plan evaluation. This retrospective study included 245 BMCS lesions from 132 patients who underwent radiotherapy, including 88 lesions treated with whole-brain radiation therapy (WBRT), 67 treated with local radiation therapy (LRT), and 90 treated with simultaneous integrated boost (SIB). The gross tumor volumes (GTVs) from the original clinical treatment plans, which had be…
- Europe PMC · Published · First archived
Toward A Whole-Brain Interface Enabled by High-Resolution Surface Electrophysiology ↗
The goal of building a whole-brain interface - capable of generating a real-time digital representation of the state of the entire central nervous system - has long been framed as a hardware challenge of recording simultaneously from ever-larger numbers of microelectrodes. Advances in high-resolution neural interfaces now enable electrophysiologic interaction with the human nervous system at spatial and temporal resolutions previously unattainable without disrupting tissue architecture or physiology. These capabilities create new opportunities for mechanistic neuroscience, neuroprosthetics, an
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How to assess evidence about Neuroscience
Check each original source for its methods, release status, limitations, and supporting data. A repository announcement, a preprint, and a published study provide different kinds of evidence. SYMTRI’s subject classification helps discovery; it does not independently validate the source’s claims.
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