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Earlier sources: Biotechnology
This science thread follows biotechnology through original research, public projects, and source reports. Read the evidence below to see which developments are represented in SYMTRI’s archive.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗235 classified signals in the fourteen-day window. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- OpenAlex · Published · First archived
Complete genome sequence of the putative plant growth-promoting bacterium Pseudomonas gorinensis strain NG1 isolated from a high-lipid algae strain ↗
ABSTRACT We report the genome sequence of Pseudomonas gorinensis NG1 isolated from alongside the alga Nannochloropsis gaditana . Bacteria capable of growing alongside algae cultured for biofuel production were isolated. The genome is 7,017,688 bp with 60.73% GC content and was sequenced with Oxford Nanopore technology and assembled with Flye.
- OpenAlex · Published · First archived
Targeting of Protein Persulfidation in Aging and Age-Related Disorders ↗
Aging is associated with a progressive loss of proteostasis and increased susceptibility to neurodegenerative and metabolic disorders. Among the molecular mechanisms implicated in these processes, protein persulfidation, a hydrogen sulfide (H2S)-mediated cysteine modification, has emerged as a critical regulator of protein function and redox homeostasis. Recent studies demonstrate that aging is accompanied by a decline in persulfidation and a concomitant increase in irreversible cysteine hyperoxidation, leading to protein dysfunction and aggregation. Beyond its established role in protecting p…
- OpenAlex · Published · First archived
Chromosome‐Level Genome Assembly of Strauchbufo raddei and Multi‐Omic Insights Into Drought Adaptation ↗
ABSTRACT Understanding how amphibians adapt to terrestrial and arid environments is important for elucidating vertebrate terrestrialization. In this study, we present the first chromosome‐level, high‐quality genome assembly of Strauchbufo raddei , constructed using PacBio HiFi long‐read sequencing and Hi‐C scaffolding. The assembled genome is 4.47 Gb in size, with a scaffold N50 of 575 Mb and 94.5% BUSCO completeness, and 99.8% of sequences anchored to 11 chromosomes, providing a valuable genomic resource for amphibian evolutionary and ecological studies. Comparative genomic analyses identifie…
- OpenAlex · Published · First archived
A selectivity filter in Tim17 mediates intramitochondrial protein sorting ↗
Abstract Mitochondria import hundreds of proteins into the matrix and the inner membrane (IM). The translocase of the IM of mitochondria (TIM23 complex) sorts these proteins using topogenic signals in their structure and directs them into the matrix or inserts them into the IM. How these signals are deciphered is unknown. Here we show that Tim17, the protein-conducting subunit of the TIM23 complex, contains a highly conserved selectivity filter for incoming proteins. Using a fluorescence-based sorting reporter, we identified the mitochondrial oxidoreductase Dmo2 (akin to DMAC1 in humans) as fa…
- OpenAlex · Published · First archived
High-throughput single-spore genome sequencing of filamentous ascomycete fungi using the SAG-gel platform ↗
Abstract Background Fungal genomic resources remain biased toward taxa that can be cultured, enriched, or isolated in sufficient biomass. Amplicon and metagenomic surveys reveal extensive diversity but do not preserve the genome context of individual propagules, and recovery of low-abundance fungal genomes from complex samples remains difficult. Fungal single-cell genomics provides a complementary approach, but current workflows remain limited in throughput, taxonomic scope, and sample requirements. Unicellular spores provide a practical target because they are discrete biological units of dis…
- OpenAlex · Published · First archived
Mitochondrial Unfolded Protein Response Under Hypoxic Conditions ↗
Hypoxia is a critical condition affecting the physiological and pathophysiological processes in the cellular environment due to depleted oxygen levels.Under hypoxic conditions, cells undergo a series of changes to adapt to the lack of oxygen that is vital for cellular metabolism in higher organisms.Importantly, hypoxia may induce organelle-specific molecular alterations, including misfolded/unfolded proteins.As a fundamental response to these changes, the unfolded protein response (UPR) is triggered by organelles, including the endoplasmic reticulum (ER) and mitochondria.UPR in mitochondria (U…
- OpenAlex · Published · First archived
Advances in and Applications of Genome Editing in Precision Crop Breeding ↗
Genome editing is becoming an important tool for crop improvement by enabling precise modification of genetic variation. CRISPR-Cas technologies have expanded beyond nuclease-induced mutations to include base and prime editing, transcriptional and epigenetic regulation, multiplex editing, organelle editing and targeted DNA insertion. These advances support the development of agronomically valuable alleles and extend crop improvement beyond conventional selection, recombination and random mutagenesis. Applications now include plant architecture, yield-related traits, resistance to biotic and ab…
- OpenAlex · Published · First archived
Ligation-assisted DNA strand displacements and CRISPR/Cas14 cleavage for ultrasensitive detection of PIWI-interacting RNA ↗
PIWI-interacting RNA (piRNA) as a type of small non-coding RNA holds great promise for managing disease occurrence and progression. Herein, we construct a ligation-assisted DNA strand displacement strategy for enhanced CRISPR/Cas14 cleavage, which provides remarkable SERS and electrochemical responses to indicate trace piRNA information. The upstream reaction is rationally designed to integrate traditional strand displacement amplification (SDA) and ligation-mediated target recycling, which benefits improvement of the efficiency. The generated single-stranded DNA products can activate trans-cl…
- OpenAlex · Published · First archived
Genome accessibility reveals disease risk that gene expression misses ↗
Most disease-associated genetic alterations do not affect the genes themselves, but instead change how strongly they are expressed, often by modifying genome accessibility. Gene expression and accessibility have now been analysed simultaneously in 10 million immune cells from 1,108 people, linking disease-associated changes in accessibility to gene expression. The effects of disease-associated genetic variants on gene expression and genome accessibility have been analysed together.
- OpenAlex · Published · First archived
Complete genome sequence and methylome analysis of Dermacoccus nishinomiyaensis strain 1-2 isolated from sushi ↗
ABSTRACT Dermacoccus nishinomiyaensis is an actinomycete whose isolation from diverse environments and potential for opportunistic pathogenicity have been documented. Here, we report the complete genome sequence of D. nishinomiyaensis 1-2, isolated from sushi. We provide annotation statistics and insights, such as the antiphage systems arsenal of the strain, including its methylome.
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How to assess evidence about Biotechnology
Check each original source for its methods, release status, limitations, and supporting data. A repository announcement, a preprint, and a published study provide different kinds of evidence. SYMTRI’s subject classification helps discovery; it does not independently validate the source’s claims.
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