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Earlier sources: Biotechnology
This science thread follows biotechnology through original research, public projects, and source reports. Read the evidence below to see which developments are represented in SYMTRI’s archive.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗224 classified signals in the fourteen-day window. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- OpenAlex · Published · First archived
Effects of a chickpea protein hydrolysate on exercise-induced biomarkers of muscle damage and inflammation in federated road cyclists ↗
Background This randomized, double-blind, placebo-controlled trial examined the effects of a chickpea protein hydrolysate (CPH) on biomarkers associated with exercise-induced muscle damage and inflammation in federated male road cyclists.Methods Twenty-four participants completed a 14-day intervention receiving either 12 g/day of chickpea protein hydrolysate (EXP) or a placebo (PLA) following training sessions. The selected dose was based on previous studies demonstrating antioxidant and immunomodulatory bioactive properties of the hydrolysate. Nutritional intake and training were registered.…
- OpenAlex · Published · First archived
A curated genome-scale nucleotide diversity panel of non-human primates ↗
Primates constitute one of the most phylogenetically and ecologically diverse eutherian mammalian orders and have a central role in advancing our knowledge of human evolution, speciation processes, and conservation biology. Although thousands of whole-genome sequences are available across many primate taxa, discrepancies in data processing—particularly the lack of ploidy-aware variant calling in sex-linked regions—have limited the utility of existing datasets for large-scale comparative analyses. Here, we use publicly available short-read sequencing data from non-human primates, recently publi…
- OpenAlex · Published · First archived
GroScore: Automated Scoring of Protein–Protein Interactions Using Bidirectional Steered Molecular Dynamics ↗
Abstract GroScore is an open-source Python toolkit that automates the scoring of protein–protein structures using bidirectional steered molecular dynamics (SMD) simulations with explicit solvent. Building on a previously published unidirectional pulling approach, the current version introduces bidirectional pulling (unbinding and rebinding), interface cutout for reduced computational cost, support for three force fields (AMBER19SB, CHARMM36m, GROMOS 54A8), and automated handling of small molecules and noncanonical amino acids (using OpenFF), structural ions, and crystal waters. GroScore integr…
- Europe PMC · Published · First archived
Caregiver's perspectives toward genome sequencing in children with neurodevelopmental disorders: Integrating genomic information into pediatric care. ↗
The increasing integration of clinical genome sequencing (GS) into pediatric care has the potential to improve diagnostic understanding for children with neurodevelopmental disorders (NDDs), yet questions remain regarding how families interpret and experience genomic information. This study examined caregivers' decision-making regarding GS, their understanding and emotional responses to genetic results, and the perceived significance and utility of GS among families of children with NDDs. Participants (N = 12) were self-identified Black or Hispanic/Latino(a) caregivers of children with NDDs (a
- Europe PMC · Published · First archived
Efficient production of recombinant human serum albumin in Escherichia coli via oxidative folding mediated by the a domain of protein disulfide isomerase. ↗
Efficient production of properly folded, disulfide-rich proteins in the cytosol of Escherichia coli remains challenging because the cytosol is highly reducing. Here, we developed an expression system for recombinant human serum albumin (rHSA) by fusing the a domain of human protein disulfide isomerase (PDI) to the N-terminus of HSA. PDI(a)-mediated cis-fusion enabled high-level production of soluble rHSA in oxidizing E. coli strains under low-temperature conditions. Purified E. coli-rHSA was predominantly monomeric and had the molecular mass expected for HSA containing 17 intramolecular disulf
- Europe PMC · Published · First archived
Genome-Wide Characterization of the DUF966 Gene Family in Rice and Functional Analysis of OsDSR6 via Overexpression. ↗
We previously identified seven members of the domain of unknown function 966 (DUF966) family in rice and showed that OsDSR2 and OsDSR3 regulate tolerance to drought, salinity and alkali stresses. However, bioinformatic characterization of this family remains limited, and the biological functions of the remaining members are largely unexplored. In this study, we performed a systematic bioinformatic analysis of the structure and potential function of the rice DUF966 family and focused on the unidentified member OsDSR6 in salinity tolerance. Phylogenetic and collinearity analyses showed that DUF9
- Europe PMC · Published · First archived
Construction of red-spotted grouper nervous necrosis virus (RGNNV) nonstructural protein B1/B2 mutant strains and dynamics during infection. ↗
Nervous necrosis virus (NNV) is a neurotropic pathogen that causes serious losses in aquaculture worldwide. B1 and B2 proteins, nonstructural proteins of NNV, play vital roles in viral function. In this study, a plasmid-based reverse genetics system was established for red-spotted grouper nervous necrosis virus (RGNNV), and codon mutations on B1 and B2 proteins were introduced. One recombinant virus (recomb) and five mutant viruses (B1QM, B2QM, BoQM, B1JM, and B2JM) were successfully rescued. Mature virions of approximately 30 nm in diameter within intracellular vacuoles were observed under tr
- Europe PMC · Published · First archived
Multi-environment genome-wide association study reveals genetic loci associated with drought tolerance during wheat germination. ↗
This study used multi-index evaluation and GWAS to identify QTLs and candidate genes for wheat germination drought tolerance, notably a 5D pleiotropic hotspot associated with multiple traits, offering breeding targets. Drought tolerance during wheat germination is critical for uniform seedling establishment in arid and semi-arid regions, ultimately affecting final yield. However, the genetic basis of drought tolerance at this stage remains less understood compared to later growth phases. In this study, a natural population of 389 wheat varieties was evaluated under three independent annual env
- Europe PMC · Published · First archived
Complete assembly of Onobrychis viciifolia mitochondrial genome reveals evolutionary dynamics. ↗
This study presents the mitogenome characteristics analysis of Onobrychis viciifolia, including anatomization of repeat sequences, RNA editing site prediction, substitution rate estimation, and phylogenetic and collinearity analyses. Onobrychis viciifolia is a perennial forage legume with high crude protein content. Although its chloroplast genome has been characterized, the mitochondrial genome (mitogenome) had not previously been annotated. In this study, we assembled the first complete mitogenome of O. viciifolia using a hybrid approach, integrating Illumina NovaSeq short-read and Nanopore
- Europe PMC · Published · First archived
Cell-resolved testing of network-pharmacology candidates in dilated cardiomyopathy: PI3K-AKT-associated transcriptional differences are distributed across cardiac lineages and are not enriched above a genome-wide background. ↗
Network pharmacology nominates targets but cannot show that they are altered in the relevant cell, distinguishable from a hypothesis-free analysis of the same data, or linked to disease. Taking the candidates nominated for Yangxin Decoction in dilated cardiomyopathy (DCM) and viral myocarditis, we asked how many survive independent functional-genomic testing. Few did. A direct-evidence intersection returned 61 genes, but across four bulk cardiac datasets the set was differentially expressed no more often than the transcriptome-wide background in any human cohort, and AKT1 was significant in no
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How to assess evidence about Biotechnology
Check each original source for its methods, release status, limitations, and supporting data. A repository announcement, a preprint, and a published study provide different kinds of evidence. SYMTRI’s subject classification helps discovery; it does not independently validate the source’s claims.
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