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Earlier sources: Biotechnology
This science thread follows biotechnology through original research, public projects, and source reports. Read the evidence below to see which developments are represented in SYMTRI’s archive.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗229 classified signals in the fourteen-day window. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- OpenAlex · Published · First archived
Genome-wide discovery of cis-regulatory elements in a large genome ↗
Identifying cis- regulatory elements typically relies on trial and error to test the activity of DNA fragments using reporter constructs. This approach is particularly challenging in large eukaryotic genomes, where cis- regulatory elements can be dispersed over long distances, separated by large stretches of non-functional DNA. Here, we generate two types of resources that can be used to narrow the search for such elements in the 3.6 Gbp genome of Parhyale hawaiensis . First, we use bulk ATAC-seq to uncover genome-wide patterns of chromatin accessibility in Parhyale embryonic and adult tissues…
- OpenAlex · Published · First archived
Human Protein Biomarkers Outperform Bacterial Proteins in Colorectal Cancer Detection ↗
Colorectal cancer (CRC) generally develops from precancerous adenomatous lesions, including advanced adenomas (AA), through a sequence of carcinogenic molecular alterations. The composition of the gut microbiota and the fecal proteome is known to differ between individuals with AA and CRC compared to controls, providing opportunities for biomarker discovery. This study aims to assess the potential of bacterial proteins as non-invasive biomarkers alone or in combination with human proteins. Therefore, two fecal sample sets from a colonoscopy-controlled population were analyzed: sample set 1 (CR…
- OpenAlex · Published · First archived
Retrospective Application of Genome-Based Newborn Screening Platforms Identifies Diagnoses in Critically Ill Children ↗
Purpose To evaluate the proportion of children in intensive care units (ICU) that were diagnosed with genetic diseases that could have been identified by population newborn screening by genome sequencing (gNBS) at birth. Methods A multi-site retrospective observational cohort study of patients admitted to the neonatal, pediatric, or cardiac ICU at two tertiary children's hospitals between July 2017 and March 2025 and received rapid diagnostic genomic sequencing (RDGS) during ICU admission. RDGS results were translated to gNBS results for 778 genes included in three gNBS research platforms. Res…
- OpenAlex · Published · First archived
Genome-wide analysis of genetic modifiers of Crohn’s disease and ulcerative colitis risk in response to tobacco smoking ↗
Background Gene-environment interactions (GxE) are fundamental for understanding the mechanisms of human diseases. Tobacco smoking is of particular interest for Inflammatory bowel disease (IBD), as it worsens Crohn's disease (CD) but protects against ulcerative colitis (UC). Here, we systematically examined the genome-wide genetic modifiers of tobacco smoking and analysed functional smoking-dependent expression quantitative trait loci (eQTL) in IBD intestinal tissues. Methods Multiplicative interaction effects of genetic variants and tobacco smoking were estimated and meta-analysed from two in…
- OpenAlex · Published · First archived
Caenorhabditis elegans small heat-shock protein HSP-12.6 has a highly specialized protective function towards muscle thick filaments in vivo ↗
Small heat-shock proteins (sHSPs) are an ancient and diverse class of molecular chaperones, acting as a first line of defence against proteotoxic stresses. While the canonical sHSPs prevent uncontrollable aggregation of a broad range of non-native substrates, a subset of sHSPs do not exhibit this broad activity in vitro, and their functions in vivo are poorly understood. Interestingly, several such sHSPs are selectively expressed in muscle tissues, including by myogenic programmes, indicating probable functional roles. We examined in vivo function of Caenorhabditis elegans HSP-12.6, which poss…
- OpenAlex · Published · First archived
Draft genome sequence of Acinetobacter soli CELK8 isolated from the taro ( Colocasia esculenta ) rhizosphere ↗
CELK8, isolated from the taro rhizosphere in Bangladesh, revealed a 3,478,463 bp genome assembled into 126 contigs with 43.0% GC content and 126.5× coverage. Genome analysis predicted genes linked to plant growth-promoting (PGP) traits and biosynthetic gene clusters, highlighting its multi-trait PGP potential.
- OpenAlex · Published · First archived
Peptide-protein interactions in drug discovery ↗
Peptide-protein interactions are emerging as a major focus in drug discovery because they underpin many biological processes and provide a powerful means to modulate protein-protein interactions (PPIs), including targets long considered "undruggable." Peptide therapeutics occupy a unique middle ground between small molecules and biologics, combining high target selectivity with structural and functional versatility. This review integrates experimental and computational perspectives, summarizing current strategies for peptide ligand discovery, AI-based modeling, and generative peptide design. W…
- Europe PMC · Published · First archived
Base-mismatched crRNA in CRISPR Enabled Universal One-pot Rapid Nucleic Acid Detection ↗
CRISPR-Cas12a-based diagnostics are promising for field detection yet are often constrained by two step workflows or laborious optimization of one-pot reactions. Herein, we present a universal one-pot RPA/CRISPR-Cas12a strategy using base-mismatched crRNA in the seed region (positions 1-6). Introducing of single-nucleotide mismatches (complementary or error) into crRNA suppresses cis‑cleavage activity, enabling amplification and detection in a single tube without PAM re-design or costly modified crRNA. Molecular dynamics (MD) simulations indicated that moderate potential energy (PE) variation
- Europe PMC · Published · First archived
Chromosome-level genome assembly of the Olympia oyster (Ostrea lurida), the only oyster species native to the West Coast of North America ↗
The Olympia oyster ( Ostrea lurida ) was once a major food source and a key component of coastal marine ecosystems and culture on the US West Coast. Overfishing and habitat contamination in the early to mid-20th century severely depleted populations of Olympia oysters, and the species is currently considered a species of concern. Although multiple restoration efforts are underway, progress understanding the species biology and recovery potential has been limited by the historical lack of genomic resources. Here, we report a chromosome-level assembly of the Olympia oyster. The assembly was buil
- Europe PMC · Published · First archived
Cross-source proteogenomic profiling of human microglia reveals a conserved core membrane protein and HERV signature ↗
Microglia are essential immune cells of the brain parenchyma which are responsible for maintaining homeostasis and responding to brain injury. When activated, they induce immune signaling and become phagocytic. In the context of neurodegenerative diseases, they exhibit both pro- and anti-inflammatory properties. Human endogenous retroviruses (HERVs) are the remnants of ancient retroviral germline infections that integrated into the human genome, and their expression has been directly linked to microglial-mediated neurodegenerative diseases. Despite this, HERV expression is not consistently inc
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How to assess evidence about Biotechnology
Check each original source for its methods, release status, limitations, and supporting data. A repository announcement, a preprint, and a published study provide different kinds of evidence. SYMTRI’s subject classification helps discovery; it does not independently validate the source’s claims.
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