THE INTERNET IS THINKING
Earlier sources: Biotechnology
This science thread follows biotechnology through original research, public projects, and source reports. Read the evidence below to see which developments are represented in SYMTRI’s archive.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗230 classified signals in the fourteen-day window. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- OpenAlex · Published · First archived
Genome-Wide Identification of the WRKY Gene Family in Mulberry and Screening of Consistently Drought-Responsive Candidates ↗
Background: WRKY transcription factors are widely involved in plant responses to drought. Mulberry (Morus alba) is an economically important tree in Southwest China, yet its WRKY gene family has not been systematically characterized at the genome level. Methods: In this study, we identified the WRKY gene family in mulberry by integrating bioinformatic analysis with transcriptome data and experimental verification. Results: A total of 56 MnWRKY genes were identified and classified into three major groups (I–III), with group II further divided into five subgroups (IIa–IIe). Promoter analysis det…
- OpenAlex · Published · First archived
Assessment of serological markers (interleukin-37, interleukin-40, antinuclear antibody and PA-Ab) and protein tyrosine phosphatase nonreceptor type 22 genetic profiles in children with immune thrombocytopenia: A case–control study ↗
Abstract: BACKGROUND: Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by reduced platelet count; this condition ranges from mild symptoms to life-threatening bleeding. The protein tyrosine phosphatase nonreceptor type 22 ( PTPN22) gene codes for an enzyme called phosphatase, which controls cell signals in immune responses, specifically in T-cells. Mutations within this gene could impact the functioning of the immune system and have been considered risk factors in ITP patients. OBJECTIVES: To assess immune biomarkers (interleukin [IL]-37, IL-40, Antinuclear antibody (ANA)…
- OpenAlex · Published · First archived
The genome sequence of the Warted Knot-Horn moth, Acrobasis repandana Fabricius, 1798 ↗
We present a genome assembly from an individual female specimen of Acrobasis repandana (Warted Knot-Horn moth; Arthropoda; Insecta; Lepidoptera; Pyralidae). The genome sequence has a total length of 620.40 megabases. Most of the assembly (99.78%) is scaffolded into 32 chromosomal pseudomolecules, including the Z and W sex chromosomes. The mitochondrial genome has also been assembled and is 15.21 kilobases in length. Gene annotation of this assembly on Ensembl identified 11,522 protein-coding genes.
- OpenAlex · Published · First archived
Conserved and Tissue‐Specific RNA and Protein Cargos of Small Extracellular Vesicles From 120 Tissue Sites Across 34 Organs in a Single Pig ↗
ABSTRACT Small extracellular vesicles (sEVs) carry diverse cargo essential for intercellular communication, but their organism‐wide characterization across all tissues is still limited. Here, we present a multi‐omics sEV atlas covering the whole‐body of 120 tissue sites, four body fluids and nine gastrointestinal contents from the same pig. We identified 7995 proteins, 337 miRNAs as well as 105,409 transcripts (93,409 full‐length) in sEVs by mass spectrometry, next‐ and third‐generation RNA sequencing. Among these, a conserved cargo set of 252 proteins, 18 miRNAs and 1227 transcripts was defin…
- OpenAlex · Published · First archived
Genome-wide identification of the YABBY gene family in wax gourd (Benincasa hispida) and functional analysis of BhYAB2 in fruit and leaf development ↗
Abstract Background The YABBY transcription factor family plays a central regulatory role in lateral organ morphogenesis in plants, yet its functions in wax gourd ( Benincasa hispida ) remain poorly understood. Results Eight BhYAB genes belonging to five subfamilies were identified in the wax gourd genome, each closely related to homologous proteins of Arabidopsis thaliana and other cucurbits. Gene structure and conserved motifs were highly conserved within the family, and the promoters contained multiple hormone-responsive elements. BhYAB2 , the member with the most fruit-specific expression…
- OpenAlex · Published · First archived
One-Step Protein Half-Life Estimation from Irreversible Inhibition and Degradation Time Courses ↗
Abstract The half-life of proteins plays a pivotal role in understanding their stability, turnover rate, and functional lifespan within a cell. In this work, we analyze the turnover equation for irreversible protein modifications, such as those occurring during covalent inhibition and targeted protein degradation by PROTACs or molecular glue degraders. Based on this analysis, we introduce a formula for straightforwardly determining protein half-life directly from the time course of unmodified protein. This approach offers a practical and efficient alternative for estimating half-lives, complem…
- OpenAlex · Published · First archived
TCR–mTORC1 signaling promotes epigenetic stabilization of Foxp3 expression in regulatory T cells via TET protein translation ↗
Regulatory T (Treg) cell differentiation and function rely on stable expression of the master transcription factor Foxp3. While Foxp3 expression is epigenetically stabilized through DNA demethylation of a Foxp3 enhancer (the Treg-specific demethylated region, TSDR), the mechanisms underlying this process remain unclear. Here, we show that strong and sustained T cell receptor (TCR) signaling promotes TSDR demethylation, stabilizes Foxp3 expression, and confers suppressive activity in in vitro–induced Treg (iTreg) cells through activation of mTORC1. Mechanistically, TCR–mTORC1 signaling promotes…
- OpenAlex · Published · First archived
Complete genome sequence of Photobacterium damselae strain HNDF01 isolated from diseased Plectropomus leopardus in Hainan, China ↗
ABSTRACT We report the complete genome sequence of Photobacterium damselae subsp. damselae strain HNDF01, isolated from diseased Plectropomus leopardus in Hainan, China. The genome consists of two circular chromosomes (4,174,829 bp) and one plasmid (160,669 bp), encoding 3,753 protein-coding genes, 217 tRNAs, 47 rRNAs, and 10 sRNAs.
- OpenAlex · Published · First archived
The haplotype-resolved, chromosome-scale genome assembly of the hexaploid Magnolia wufengensis provides valuable insights into genome evolution and the biosynthesis genes for flower color and fragrance ↗
Magnolia wufengensis is a newly discovered species within the Magnoliaceae family. This tree is notable for its attractive fragrance and striking red flowers. Although M. wufengensis has significant ecological and ornamental value, a lack of genomic resources hindered use and protection of this tree. Here, a high-quality, haplotype-resolved chromosome-scale genome assembly of 11.98 Gb was generated, comprising 114 pseudochromosomes. Genome duplication analysis indicated that the hexaploid formation occurred approximately 6.8 million years ago (MYA), which is later than the divergence time from…
- OpenAlex · Published · First archived
Sclerostin regulates bone morphogenetic protein ( BMP ) bioavailability through interactions with BMP complexes and fibrillin microfibrils ↗
Sclerostin (SOST) is a secreted glycoprotein that antagonizes Wnt and BMP signaling, however, the molecular mechanisms regulating its extracellular distribution and growth factor (GF) interactions remain poorly understood. Here, we identify fibrillin microfibrils as high-affinity extracellular binding partners of SOST. Recombinant SOST bound specifically to fibrillin-1 positive fibers in cell culture and localized near the bead region of purified tissue fibrillin microfibrils. Surface plasmon resonance (SPR) mapping revealed that SOST recognizes the N-terminal regions of fibrillin-1 and fibril…
Live window recorded . This is the ingestion observation time, not the publication or discovery date of each source.
How to assess evidence about Biotechnology
Check each original source for its methods, release status, limitations, and supporting data. A repository announcement, a preprint, and a published study provide different kinds of evidence. SYMTRI’s subject classification helps discovery; it does not independently validate the source’s claims.
See the collection and counting methodology ↗ · Read the weekly synthesis ↗
Related threads
Explore related regions
These navigation suggestions are part of the map’s editorial structure, rather than measured evidence of a connection.