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Earlier sources: Science
Science investigates the natural world through observation, experiments, and mathematical models. Explore papers and developments in biology, medicine, materials, neuroscience, physics, climate, and mathematics; a reported finding is not necessarily established consensus.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗1322 classified signals in the fourteen-day window. Recent momentum: steady. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- OpenAlex · Published · First archived
Association between the C-reactive protein-to-albumin ratio and mechanical circulatory support device application in patients with advanced heart failure ↗
Abstract Background The C-reactive protein-to-albumin ratio (CAR) is an easily accessible biomarker that reflects both systemic inflammation and nutritional reserve. This study aimed to evaluate the association between CAR and mechanical circulatory support (MCS) device application in patients with advanced heart failure. Methods This single-center retrospective observational study included 246 patients evaluated for advanced heart failure between January 2024 and December 2024. Advanced heart failure was defined according to European Society of Cardiology criteria. Patients were grouped accor…
- OpenAlex · Published · First archived
ERGA-BGE genome of Valencia hispanica (Valenciennes, 1826): a critically endangered Iberian toothcarp ↗
The reference genome of Valencia hispanica , a critically endangered actinopterygian species endemic to the Iberian Peninsula, is key to unravelling its genetic architecture and adaptation to freshwater ecosystems. This genomic resource will enable targeted conservation efforts and shed light on the species’ essential role in ecological dynamics, including its contributions to algal biomass regulation and role in the aquatic food web while also highlighting the challenges it faces from habitat degradation and invasive species. Furthermore, it offers opportunities to gain valuable insights into…
- OpenAlex · Published · First archived
Circulating Tumor DNA (ctDNA) for Minimal Residual Disease (MRD) Detection in Colorectal Cancer (CRC): Current Evidence, Clinical Applications, and Future Directions ↗
Minimal residual disease (MRD) is a major contributor to colorectal cancer (CRC) recurrence following curative-intent treatment, yet conventional surveillance methods may fail to detect residual disease at its earliest stages. Circulating tumor DNA (ctDNA) has emerged as a minimally invasive biomarker for MRD detection and postoperative monitoring. We conducted a structured PubMed-based literature review and included 94 publications evaluating ctDNA in CRC. Across the literature, postoperative ctDNA positivity was consistently associated with increased recurrence risk and poorer disease-free a…
- OpenAlex · Published · First archived
Genetic Diversity and Clonal Dissemination of ESBL-Producing Klebsiella pneumoniae from Clinical, Food, and Animal Sources in Bouaké, Côte d’Ivoire ↗
Klebsiella pneumoniae is a major opportunistic pathogen responsible for multidrug-resistant infections in both hospital and community settings. The emergence and spread of extended-spectrum β-lactamase (ESBL)-producing strains have become a major public health concern due to limited treatment options and their potential spread among human, animal, and food reservoirs. This study aimed to assess the genetic relatedness of ESBL-producing K. pneumoniae isolates collected from human clinical samples, ready-to-eat foods, and animal sources using ERIC-PCR profiling. A total of 98 ESBL-producing K. p…
- OpenAlex · Published · First archived
Irreversible electroporation for liver metastases not amenable to conventional treatments, an experience with technical challenges, clinical outcomes, and complications ↗
Irreversible electroporation (IRE) is a non-thermal ablation technique for perivascular liver tumors unsuitable for conventional thermal ablation due to heat-sink effects. This prospective, single-center, single-arm study (2020–2025) evaluated IRE in 14 patients with 16 anatomically challenging liver metastases (median size 20 mm; range 6–50 mm) following multidisciplinary exclusion from resection or thermal ablation. At one month, primary technical success was 94.4%, achieving complete responses in 100% of tumors 3 cm. Median local recurrence-free survival was 9 months, with a 2-year local re…
- OpenAlex · Published · First archived
Rational Control of Antibody Orientation for Enhancing Sensitivity and Specificity in Lateral Flow Immunoassays With Clinical Validation ↗
Lateral flow assays (LFAs) are widely used for point-of-care diagnostics, but their sensitivity is often limited by inefficient antibody orientation and poor signal transduction. Herein, we report a universal strategy integrating orientation-controlled antibody conjugation at the immunoprobe with a biotin-streptavidin-modified test line to enhance LFA sensitivity, specificity, and analytical reliability. Using an orientation-controlled conjugation approach (P-6, Scheme 1), antigen accessibility was maximized while nonspecific adsorption and false-positive signals were suppressed. Compared with…
- OpenAlex · Published · First archived
Chromatin Modifications Orchestrate DNA Repair Pathway Choice: Epigenetics Strategies for Enhancing CRISPR –Cas9‐Mediated Knock‐In Efficiency ↗
CRISPR-Cas9-mediated precise gene knock-in relies on homology-directed repair (HDR) at low frequencies in most mammalian cells, limiting precise gene editing in both research and therapeutic applications. Although multiple strategies have been developed to increase knock-in efficiency, their application can be restricted by technical complexity, limited applicability, or potential safety concerns. In this review, we propose a shift in focus from conventional strategies toward epigenetic methods to increase knock-in efficiency. It has been proved that histone modifications such as H3K36me3, H3K…
- OpenAlex · Published · First archived
Pyroglutamyl peptide–rich rice protein hydrolysate restores cecal N -acetyl amino acids in high-fat-diet–fed rats, outperforming short-chain fatty acids as early microbial markers ↗
Abstract Pyroglutamyl-leucine (pyroGlu-Leu) is a food-derived modified peptide known to modulate the gut microbiota. This study examined the effects of orally administered rice protein hydrolysate (RPH) containing pyroGlu-Leu in rats fed a 45% high-fat diet that induced mild dysbiosis without obesity or severe liver dysfunction. In addition to short-chain fatty acids (SCFAs), several N-acetyl amino acids (NAAAs) were detected in cecal contents. The high-fat diet significantly decreased both SCFAs and NAAAs, whereas administration of RPH or synthetic pyroGlu-Leu restored the levels of NAAAs des…
- OpenAlex · Published · First archived
Multi-locus genome-wide association study reveals the genetic architecture of kernel fat content in maize ↗
Kernel fat content (KFC) is a key determinant of oil quality and nutritional value in maize, yet the genetic architecture underlying its natural variation remains incompletely understood. Here, we performed a genome-wide association study (GWAS) using 239 maize inbred lines genotyped with 1.25 million single nucleotide polymorphisms (SNPs), applying six complementary statistical models: MLM, MLMM, FarmCPU, BLINK, SUPER, and 3VmrMLM. KFC exhibited substantial phenotypic variation across the three environments, ranging from 5.48% to 8.72%, with a broad-sense heritability (H²) of 0.81. In total,…
- OpenAlex · Published · First archived
Protocol for genome-wide differential methylation using long-read DNA sequencing in the cortex of a mouse model of Alzheimer’s disease ↗
Third-generation sequencing enables direct detection of genome-wide 5-methylcytosine without bisulfite conversion. Here, we present a protocol for generating long-read DNA sequencing from mouse cortex and performing genome-wide differential methylation analysis. We describe steps for high-molecular-weight DNA extraction, data generation, and downstream analysis. We demonstrate the workflow in the App NL-G-F mouse model of amyloid pathology and provide a reproducible pipeline that links modified-base BAM (modBAM) files to annotated differentially methylated regions and functional enrichment res…
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How to assess evidence about Science
Check each original source for its methods, release status, limitations, and supporting data. A repository announcement, a preprint, and a published study provide different kinds of evidence. SYMTRI’s subject classification helps discovery; it does not independently validate the source’s claims.
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