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Earlier sources: Science
Science investigates the natural world through observation, experiments, and mathematical models. Explore papers and developments in biology, medicine, materials, neuroscience, physics, climate, and mathematics; a reported finding is not necessarily established consensus.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗1324 classified signals in the fourteen-day window. Recent momentum: steady. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- OpenAlex · Published · First archived
Role of calcineurin B homologous protein 3 in C2C12 myogenic differentiation ↗
Calcineurin B homologous protein 3 (CHP3), also known as tescalcin, has been implicated in the regulation of cardiomyocyte hypertrophy, but its function in skeletal muscle remains unclear. Here, we investigated the role of CHP3 in C2C12 myogenic differentiation. CHP3 expression was upregulated during the differentiation of mouse C2C12 myoblasts into myotubes. Genetic deletion of CHP3 impaired myogenic differentiation, as evidenced by reduced myogenin and myosin heavy chain (MHC) expression and myocyte fusion. These defects were accompanied by decreased phosphorylation of key signaling proteins…
- OpenAlex · Published · First archived
Robust NbN‐on‐Si/SiGe Hybrid Microwave Quantum Circuits With Long‐Term Stability ↗
ABSTRACT Large‐scale quantum computing requires superconducting microwave circuits that simultaneously exhibit ultra‐low loss, long‐term reliability, and scalable integration with semiconductor technologies. Achieving these capabilities within a CMOS‐compatible platform remains a major challenge, with microwave losses arising from material defects, interfaces, and fabrication processes limiting scalability. Here, we demonstrate robust niobium nitride (NbN) coplanar waveguide resonators fabricated on Si/SiGe quantum‐well heterostructures, establishing a hybrid superconducting–semiconducting mic…
- OpenAlex · Published · First archived
Graph symmetry organizes exceptional dynamics in open quantum systems ↗
Exceptional points (EPs) play a central role in non-Hermitian physics, yet most theoretical studies begin from deliberately engineered low-dimensional effective Hamiltonians whose parameters are tuned to produce spectral degeneracies. In realistic open quantum systems, however, dynamics are governed by Lindblad superoperators whose spectral structure is high-dimensional, symmetry-constrained, and generally not amenable to a priori reduction. A general framework for identifying exceptional dynamics directly from microscopic dissipative models has therefore been lacking. Here we introduce a symm…
- OpenAlex · Published · First archived
A mathematical theory of redox biology ↗
Abstract Redox biology is commonly described through functional labels, such as oxidant, reductant, antioxidant, signalling mediator or damage mediator. However, these labels do not define invariant molecular properties. A molecule may realize different functions depending on reaction partner, local coupling, spatial domain and prior trajectory. Function is therefore not primitive but emergent. Here, we develop a mathematical theory of redox biology from first principles. At the mesoscopic level, chemically defined molecular states are treated as objects and reactions as transformations, yield…
- Europe PMC · Published · First archived
Human FACT complex coordinates cohesin and transcription on chromatin ↗
The spatial organisation of eukaryotic genomes is critical for coordinating DNA-dependent processes such as transcription and replication. Cohesin contributes to this organisation by extruding chromatin loops; however, how cohesin achieves processive translocation along nucleosome-dense chromatin in vivo remains poorly understood. Here, we identify the histone chaperone FACT as a regulator of cohesin dynamics in human cells. We show that the FACT subunit SUPT16H colocalises and interacts with cohesin on chromatin. Depletion of FACT impairs cohesin translocation from its loading sites, leading
- Europe PMC · Published · First archived
Development of inducible genetic systems to finely tune efficacy of InhA-targeting anti-tuberculous drugs ↗
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a leading global health threat, especially due to multidrug-resistant strains. The first-line drug isoniazid (INH) and second-line drugs ethionamide (ETH) and prothionamide (PTH), are prodrugs that target the essential enoyl-ACP reductase InhA, a key enzyme involved in mycolic acid biosynthesis. Resistance to these drugs primarily arises from genetic mutations that inactivate the enzymatic function of their respective bioactivating enzymes. While the recent development of chemical boosters has shown promising results in res
- Europe PMC · Published · First archived
Loss of the Y chromosome drives basal identity and metastatic potential via epigenetic reprogramming in pancreatic cancer ↗
Loss of the Y chromosome (LOY) has been largely unexplored in pancreatic ductal adenocarcinoma (PDAC), and no mechanistic framework previously explained its role in tumor biology. We identify LOY as a recurrent, functionally consequential alteration affecting ~50% of male PDAC patients across two independent cohorts, with strong enrichment in advanced disease and, critically, in the basal subtype, establishing LOY as a clinically actionable biomarker. Comprehensive genomic profiling positions LOY as a distinct genetic event associated with TP53 mutations, implicating it in aggressive tumor evo
- Europe PMC · Published · First archived
Limitations of Genomic Foundation Models for Decoding Regulatory Mechanisms in ALS ↗
Genomic foundation models promise to infer regulatory consequences of genetic variants directly from DNA sequence, but how well these predictions translate to clinical utility remains unclear. To probe this question, we evaluate AlphaGenome (AG) for understanding amyotrophic lateral sclerosis (ALS) genetics without any disease-specific fine-tuning across three settings of increasing difficulty: recovering measured variant effects, reconstructing a known splicing mechanism, and generating de novo regulatory hypotheses at unresolved loci. At population scale, AG failed to recover measured effect
- Europe PMC · Published · First archived
Separating biological signal from statistical artifact in trait trade-off inference ↗
Trade-offs are commonly assumed when the statistical parameters used to define biological traits are negatively correlated. However, parameter correlations can emerge from the geometry of the model, rather than underlying biological signal. We characterize this phenomenon generally, and develop a framework to parse biological signal from statistical artifact in parameter correlations. Using the widely reported trade-off between thermal sensitivity and static upper critical thermal limit as a case study, we show that an extreme correlation between these parameters is expected even in the absenc
- Europe PMC · Published · First archived
Long-read sequencing reveals genomic landscape of structural variants in a major disease vector ↗
The southern house mosquito Culex quinquefasciatus is a major disease vector for multiple arboviruses, including West Nile virus and St. Louis encephalitis virus. Insecticides are widely used to control Cx. quinquefasciatus populations, but resistant mosquitoes have emerged in numerous locations across the globe, including the United States. Much progress has been made in recent years in identifying insecticide resistance (IR) mutations in various pest species. In most species, these studies have focused primarily on SNPs as they are readily detectable. However, several genomic structural vari
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Check each original source for its methods, release status, limitations, and supporting data. A repository announcement, a preprint, and a published study provide different kinds of evidence. SYMTRI’s subject classification helps discovery; it does not independently validate the source’s claims.
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