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Earlier sources: Science
Science investigates the natural world through observation, experiments, and mathematical models. Explore papers and developments in biology, medicine, materials, neuroscience, physics, climate, and mathematics; a reported finding is not necessarily established consensus.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗1373 classified signals in the fourteen-day window. Recent momentum: steady. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- OpenAlex · Published · First archived
Advances in circulating tumor DNA detection from traditional methods to diversified signal amplification biosensing strategies ↗
Circulating tumor DNA (ctDNA), as the core biomarker of liquid biopsy, carries many tumor-specific molecular characteristics and is a key carrier for non-invasive early screening and dynamic monitoring of cancer. However, the low abundance and the interference of ctDNA in peripheral blood have long constrained the development and application. Signal amplification biosensing strategies have become the core technical path to break through the bottleneck of ctDNA detection due to their high sensitivity, rapid response, and miniaturization potential. Based on the technical characteristics of vario…
- OpenAlex · Published · First archived
Differential Effects of Antibiotics on the Horizontal Transfer of blaKPC Plasmid in Clinical Klebsiella pneumoniae Strain ↗
Horizontal transfer of blaKPC-bearing plasmids contributes significantly to the dissemination of carbapenem resistance among Enterobacterales; however, the influence of mechanistically distinct antibiotics on this process remains incompletely understood. This study investigated the effects of meropenem, gepotidacin, and omadacycline on plasmid-mediated transfer of blaKPC from the carbapenem-resistant K. pneumoniae donor strain CDC120 to the ESBL-producing K. pneumoniae recipient strain DS073. Conjugation assays were performed under sub-inhibitory antibiotic concentrations, and plasmid transfer…
- OpenAlex · Published · First archived
Leviathan: fast, memory-efficient, and scalable taxonomic and pathway profiling for (pan)genome-resolved metagenomics and metatranscriptomics ↗
Functional profiling of meta-omics is essential for understanding microbial communities, yet support for custom genome-resolved reference databases is limited. We introduce Leviathan for integrated taxonomic and functional profiling at both genome and pangenome resolution. Leviathan combines Sylph for ultrafast alignment-free taxonomic profiling with Salmon for pseudo-alignment-based read quantification in DNA space against (pan)genome-resolved gene catalogs, producing dual metrics per (pan)genome: pathway abundance and graph-based pathway coverage. Benchmarking alignment backends on synthetic…
- OpenAlex · Published · First archived
Design of a novel chimeric multi-epitope vaccine construct against Staphylococcus lugdunensis using pan-genome analysis and immunoinformatics approaches ↗
Abstract Staphylococcus lugdunensis has emerged as an increasingly important opportunistic pathogen associated with invasive infections and rising antimicrobial resistance, creating a need for new preventive approaches. In this study, a reverse-vaccinology strategy integrated with immunoinformatics analyses was applied to genomic datasets derived from 29 complete genomes. Pan-genome evaluation identified 1689 conserved core proteins, from which four surface-associated proteins were prioritized as potential vaccine targets based on their predicted antigenic properties and favorable safety profi…
- OpenAlex · Published · First archived
Harnessing Paeonia lactiflora-derived antioxidant carbon dots as oral nanomedicine for ulcerative colitis therapy by restoring intestinal mucosal barrier and microbiota homeostasis ↗
The clinical management of ulcerative colitis (UC) necessitates the development of safe and efficacious oral therapeutic agents. Guided by network pharmacology predictions, this study successfully synthesized novel Paeonia lactiflora -derived carbon dots (PL-CDs) via a one-pot hydrothermal method using a single traditional Chinese medicine precursor. Physicochemical characterization and in vitro antioxidant assays demonstrated that PL-CDs possess robust, broad-spectrum radical scavenging capacity and SOD-mimetic antioxidant capacity. Cellular experiments revealed that PL-CDs were efficiently i…
- OpenAlex · Published · First archived
Case Report A Rare Cause of Cardiofaciocutaneous Syndrome—KRAS p.Pro34arg: Clinical Delineation, Diagnostic Challenges, and Implications for RASopathy Classification ↗
Background and Clinical Significance: Cardiofaciocutaneous syndrome (CFC) is a rare autosomal dominant RASopathy characterized by craniofacial dysmorphism, congenital heart defects, cutaneous abnormalities, growth impairment, and neurodevelopmental delay. Pathogenic variants in KRAS account for a minority of cases and define cardiofaciocutaneous syndrome type 2 (CFC2). Establishing a molecular diagnosis is often challenging because of the substantial clinical overlap among RASopathies, including Noonan and Costello syndromes. Case Presentation: We describe a one-year-old boy presenting with ma…
- OpenAlex · Published · First archived
Toward accessible gait analysis: a cross-modal evaluation of performance, cost and clinical validation ↗
Traditional gait analysis is based on laboratory experiments that use motion capture and force plates. While these systems deliver precise results, they also have drawbacks in terms of high cost and lack of portability, motivating research into cost-effective solutions. The following review summarizes approximately 180 recent studies spanning low-cost prototype and commercial gait analysis systems, with commercial systems included as performance benchmarks. The low-cost alternatives reviewed span five modality types: vision-based systems, inertial measurement units (IMUs), electromyography (EM…
- OpenAlex · Published · First archived
Gut microbiome enterotypes associate with distinct metabolomic landscapes and clinical outcomes in inflammatory bowel disease: a multi‑omics dissection ↗
The gut microbiota contributes to inflammatory bowel disease (IBD), but patient‑to‑patient variation in microbial dysbiosis remains poorly characterised. The gut‑brain axis is implicated in the high rate of psychiatric comorbidities in IBD, though the microbial and metabolic mediators are not fully defined. We recruited 71 healthy individuals and 178 IBD patients (104 ulcerative colitis, 74 Crohn’s disease) and performed faecal metagenomic and untargeted metabolomic sequencing. Non‑negative matrix factorisation (NMF) consensus clustering defined gut microbiome enterotypes, followed by integrat…
- OpenAlex · Published · First archived
Healthcare burden and clinical spectrum of symptomatic polycystic liver disease in Japan: a nationwide epidemiological survey ↗
Abstract Background Polycystic liver disease (PLD) is often asymptomatic, but some patients develop symptoms or complications requiring care or intervention. The nationwide burden of symptomatic PLD remains poorly defined. We conducted a nationwide survey to estimate the number and prevalence of patients with symptomatic PLD in Japan and characterize clinical features, treatment patterns, healthcare utilization, and outcomes. Methods A nationwide two-stage questionnaire survey was conducted. Symptomatic PLD was defined as 10 or more hepatic cysts with cyst-related symptoms or complications. In…
- OpenAlex · Published · First archived
Whole-genome 5-hydroxymethylation profiling of human neurons for regulatory and biological insight ↗
Abstract While 5-methylcytosine (5mC) DNA methylation is a well-known player in genome stability and transcriptional regulation, the role of 5-hydroxymethylcytosine (5hmC), particularly prevalent in neurons, remains largely unknown. Here, we used long-read Oxford Nanopore Technology (ONT) to profile whole-genome, native 5mC and 5hmC levels in sorted neuronal nuclei samples from human post-mortem brain tissue. Genomic annotation revealed high 5hmC levels in actively transcribed genes and enhancers, which were enriched in neuron-related pathways, with functional variety when stratifying across c…
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Check each original source for its methods, release status, limitations, and supporting data. A repository announcement, a preprint, and a published study provide different kinds of evidence. SYMTRI’s subject classification helps discovery; it does not independently validate the source’s claims.
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