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Earlier sources: Science
Science investigates the natural world through observation, experiments, and mathematical models. Explore papers and developments in biology, medicine, materials, neuroscience, physics, climate, and mathematics; a reported finding is not necessarily established consensus.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗1411 classified signals in the fourteen-day window. Recent momentum: steady. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- Europe PMC · Published · First archived
Genetic susceptibility, risk prediction, and druggable targets for oropharyngeal cancer: a UK Biobank study. ↗
This study aimed to systematically identify and annotate oropharyngeal cancer (OPC) genetic risk, construct OPC risk prediction models, and identify candidate drug targets for OPC treatment. The OPC genome-wide association study was conducted in the UK Biobank involving 208 OPC patients and 328,248 healthy individuals. Functional annotations were performed using the FUMA website and the Sclinker statistical framework. OPC risk prediction models were constructed using logistic regression. Mendelian randomization (MR) was employed to identify potential OPC-related drug target genes. We identifie
- Europe PMC · Published · First archived
Developmental trajectories of tonic and phasic irritability from ages 12 to 21: early predictors, co-development, and psychiatric outcomes in young adulthood. ↗
Irritability is a common and impairing, transdiagnostic feature of youth psychopathology. Theory distinguishes tonic irritability (persistent irritable mood) from phasic irritability (episodic temper outbursts), yet little is known about how these dimensions co-develop across adolescence into young adulthood and relate to later psychiatric outcomes. Participants were drawn from a longitudinal community cohort assessed at ages 12, 15, 18, and 21 (N = 532 with data at one or more waves). Tonic and phasic irritability were derived from youth-report items spanning multiple measures. We tested the
- Europe PMC · Published · First archived
Genomic epidemiology of Omicron (BA.1) as a driver of Pakistan's fifth SARS-CoV-2 wave. ↗
The emergence of the SARS-CoV-2 Omicron variant led to Pakistan's Omicron wave from December 2021 to March 2022. This study investigated the molecular epidemiology of the early Omicron wave in Pakistan through genomic surveillance and travel history-informed Bayesian phylogeographic inference. PCR-based genotyping and whole-genome sequencing shows a shift from the BA.1 lineage's early replacement of Delta as Pakistan's dominant lineage in December 2021, until it was replaced by BA.2 predominance by March 2022. We identify rare spike protein mutations and the absence of key mutations in circula
- Europe PMC · Published · First archived
Early target volume dynamics during MR-guided radiotherapy for glioblastoma: first results from the prospective MARGA-I trial. ↗
Serial MRI during radiotherapy may enable early response assessment and guide adaptive treatment strategies; however, data on intratreatment volumetric changes remain limited. We herein report results of the MARGA-I-study, investigating target volume changes during MR-linac-based radio-(chemo-)therapy. In this prospective single-center-study, 25 patients with glioblastoma were treated on a 0.35-T-MR-linac. TrueFISP and T2-FLAIR images were acquired before treatment and every fifth fraction. TrueFISP-based extended resection cavity (cavity/tumor residue) and FLAIR-hyperintense volumes were cont
- Europe PMC · Published · First archived
Immunomodulatory effects of lithium treatment in bipolar disorder: A prospective cohort study. ↗
Bipolar disorder pathophysiology remains incompletely understood but is thought to involve immune dysregulation and metabolic dysfunction. Although lithium is widely used in treatment, its biomolecular effects are not fully characterized, and no validated biomarker of treatment response exists. We conducted a prospective, longitudinal cohort study to investigate peripheral immune-related and cardiometabolic protein levels in 50 lithium-naïve patients with bipolar disorder, compared with 42 healthy controls, aiming to identify baseline differences, persistent proteomic changes during lithium tr
- Europe PMC · Published · First archived
Photo-Enhanced Electronic Metal-Support Interaction Boosts Low-Temperature Water-Gas Shift Reaction via Ni δ+ -O V -Ce 3+ Interfacial Redox Cycling. ↗
Nickel (Ni) is an attractive non-noble-metal catalyst for the water-gas shift reaction (WGSR), yet strong CO adsorption and competing methanation severely limit its activity and selectivity. Herein, we develop a series of NiCe layered double hydroxide-derived catalysts (NCO-T) through reduction-induced Ni exsolution. The optimized NCO-450 catalyst achieves 92.53% CO conversion and an H 2 production rate of 103.24 µmol·g cat -1 ·s -1 at ambient pressure and a catalyst temperature of 83°C. In situ spectroscopic analyses and theoretical calculations reveal that isolated interfacial oxygen vacanci
- Europe PMC · Published · First archived
Postbiotics enhance immune competence in black rockfish (Sebastes schlegelii): linking innate immunity, apoptosis, and resistance to bacterial infection. ↗
Background This study investigated the functional potential and safety of postbiotics derived from Latilactobacillus curvatus NBL2305 as a dietary feed additive for juvenile black rockfish (Sebastes schlegelii). Fish were fed diets supplemented with NBL2305-derived postbiotics, and their effects on growth performance, immune responses, antioxidant capacity, apoptosis-related gene expression, intestinal microbiota, and disease resistance were evaluated. Results Supplementation with postbiotics significantly improved growth performance and feed utilization, as indicated by increased weight gain
- Hacker News · Posted on Hacker News · First archived
Is Mathematics Over, or Just Graduating? ↗
Hacker News discussion.
- arXiv · Published · First archived
Topology-independent quantum advantage in communication networks ↗
Quantum communication can outperform classical communication in a variety of information-processing tasks, but such advantages are typically established for a fixed communication network. Here we introduce topology-independent quantum advantage, in which a quantum protocol outperforms every classical protocol subject to the same communication constraint, irrespective of how the classical communication resource is distributed among the parties or which communication topology is employed, even when the parties may share unlimited classical randomness. We first demonstrate this phenomenon through…
- arXiv · Published · First archived
Sum-of-squares compilation of matrix-model dynamics for NISQ and fault-tolerant hardware ↗
The SU$(N)$ matrix-model potential $V=-\tfrac{g^2}{4}\sum_{I,J}Tr[X_I,X_J]^2$, the interaction of the BFSS/BMN family, whose thermal large-$N$ states are dual to black holes, is diagonal in the coordinate basis and is compiled in the literature as a phase polynomial with $O(d^2N^4Q^4)$ rotations per Trotter step. That cost is close to optimal for its gate class: we show that for a generic Trotter step the Walsh support $m_{\min}$ lower-bounds both the rotation count and the two-qubit count of every circuit over $\{CNOT,CZ,CPhase,R_{ZZ},SWAP,X,R_z\}$, ancillas included, and we build a parity ne…
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Check each original source for its methods, release status, limitations, and supporting data. A repository announcement, a preprint, and a published study provide different kinds of evidence. SYMTRI’s subject classification helps discovery; it does not independently validate the source’s claims.
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