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Earlier sources: Science
Science investigates the natural world through observation, experiments, and mathematical models. Explore papers and developments in biology, medicine, materials, neuroscience, physics, climate, and mathematics; a reported finding is not necessarily established consensus.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗1450 classified signals in the fourteen-day window. Recent momentum: steady. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- OpenAlex · Published · First archived
Genome-Wide Identification and Expression Pattern Analysis of the Phenylalanine Ammonia-Lyase (PAL) Gene Family in Wheat Under Stripe Rust ↗
Phenylalanine ammonia-lyase (PAL) has been identified as the key rate-limiting enzyme of the phenylpropanoid metabolic pathway, which affects the synthesis of plant secondary metabolites and stress responses. To investigate the composition and function of the PAL gene family in wheat against wheat stripe rust, 54 TaPAL gene family members were identified based on the wheat IWGSC RefSeq v2.1 genome data. Phylogenetic analysis of PAL proteins from wheat, maize, rice, tobacco, and Arabidopsis indicated that wheat PAL genes are more closely related to those of maize and rice. Promoter analysis rev…
- OpenAlex · Published · First archived
m6A-modified mRNA–LNP system enables in vivo CAR expression and is associated with antitumor immune responses ↗
Messenger RNA (mRNA) therapeutics have emerged as a versatile modality for transient gene delivery, but strategies to incorporate epitranscriptomic regulation into synthetic mRNA design remain limited. Among RNA modifications, N6-methyladenosine (m 6 A) is a major regulator of mRNA stability, translation, and cellular signaling through coordinated actions of methyltransferases, binding proteins, and demethylases. However, the use of engineered m 6 A-modified mRNAs to modulate immune responses in vivo has been relatively unexplored. Here, we developed a tunable lipid nanoparticle (LNP) delivery…
- OpenAlex · Published · First archived
Sex-dependent cerebral inflammatory responses underlie sepsis-associated encephalopathy with altered brain oxylipin metabolism ↗
Sepsis-associated encephalopathy (SAE) is a common complication of sepsis with significant sex dimorphism, yet the underlying mechanisms remain unclear. Oxylipin signaling plays a crucial role in neuroinflammation, but how sex modulates cerebral oxylipin profiles during sepsis has not been systematically explored. Sepsis was induced in male and female C57BL/6 mice via cecal ligation and puncture (CLP). Targeted oxylipin metabolomics of brain tissue was performed 24 h post-CLP using LC-MS/MS. Protein expression of key enzymes and transporters was analyzed by western blot and immunofluorescence;…
- OpenAlex · Published · First archived
Early-Life Gut Microbiota and the Pediatric Gut–Lung Axis: A Systematic Review of Clinical, Preclinical, and Mechanistic Evidence ↗
Background/Objectives: The early-life gut microbiota plays a pivotal role in immune maturation and may influence respiratory health through the gut–lung axis. However, evidence linking microbial development, dysbiosis, microbial metabolites, and microbiota-targeted interventions to pediatric respiratory outcomes remains heterogeneous. This systematic review aimed to synthesize clinical and preclinical evidence on the pediatric gut–lung axis and its underlying mechanisms. Methods: This systematic review followed PRISMA 2020 guidelines and a prospectively registered PROSPERO protocol (CRD4202510…
- OpenAlex · Published · First archived
Aging-associated SATB1 deficiency remodels 3D genome architecture and transcriptional programs in naive CD4 + T cells ↗
Precise three-dimensional (3D) genome organization is crucial for regulating gene expression during development, yet its role in age-related transcriptional changes and physiological decline remains elusive. Here, we show that aging reshapes chromatin architecture and gene regulation in murine naive CD4 + T cells, a quiescent T cell population essential for adaptive immunity. Aged naive CD4 + T cells exhibit intrinsic transcriptional reprogramming marked by increased expression of inflammatory and T cell activation–related genes, rendering them more prone to activation. Intriguingly, these cha…
- OpenAlex · Published · First archived
InAsSb surface quantum well with in situ deposited Nb as a platform for hybrid devices ↗
Abstract Semiconductor-superconductor hybrid materials form the basis of quantum devices ranging from gate-tunable qubit platforms to topological quantum applications. These applications require material combinations that offer strong spin-orbit coupling and a large superconducting gap. Here, we present a semiconductor-superconductor hybrid material based on a molecular beam epitaxially grown Indium Arsenide Antimonide surface quantum well with an in-situ deposited Niobium layer. The Indium Arsenide Antimonide surface quantum well offers a low effective mass and strong spin-orbit interaction,…
- OpenAlex · Published · First archived
Design and Evaluation of Novel Peptides Targeting Protein Disulfide Isomerase as Antiplatelet Agents ↗
Extracellular protein disulfide isomerase (PDI) is a critical mediator of thrombus formation and a promising target for novel antithrombotic therapies aiming to overcome the bleeding risks associated with current antiplatelet agents. This study aimed to design and evaluate novel, targeted peptide-based PDI inhibitors with a safe physiological profile. We utilized a bioinformatics-driven rational design approach, based on the evolutionary conservation of the PDI active site, to generate a library of 34 targeted peptides. The inhibitory mechanism and biological efficacy of the lead candidate, pe…
- OpenAlex · Published · First archived
Protein Intake and Resistance Training Across Clinical Populations: A PRISMA-Guided Rapid Review of Observational and Randomized Evidence ↗
Background/Objectives: Guidance on protein and physical activity rests on population-wide minima with little differentiation by age or disease. We examined how protein intake and resistance training relate to muscle, function and mortality across clinical populations. Methods: PRISMA-guided rapid review: Fifty-eight logged PubMed queries returned 7544 unique records for screening (the analytic corpus); Europe PMC, Semantic Scholar and ClinicalTrials.gov were tested for coverage only. Estimates were extracted by a deterministic script and adjudicated by the authors; random-effects models were f…
- OpenAlex · Published · First archived
Retinol-Binding Protein 4 in Obesity-Associated Metabolic Dysfunction: Mechanisms, Controversies, and Therapeutic Opportunities ↗
Retinol-binding protein 4 (RBP4) is the primary carrier of retinol in the circulation and is produced mainly by the liver. Interest in RBP4 expanded after reports of elevated circulating levels in insulin-resistant mice and some human populations, leading to its proposal as an adipokine, an immunometabolic mediator, and a biomarker of obesity-related metabolic disease. However, subsequent research has revealed that its biology is considerably more complex. The metabolic effects of RBP4 are influenced by multiple factors, including its tissue of origin, retinol-binding status, association with…
- OpenAlex · Published · First archived
Genome-Wide Identification and Expression Dynamics of ABC Transporters in Morchella sextelata During Fruiting Body Development and Selenium Supplementation ↗
ATP-binding cassette (ABC) transporters constitute a superfamily of transmembrane transport proteins that are ubiquitously present across prokaryotic and eukaryotic organisms, exhibiting extensive substrate diversity and significant functional versatility. Yet, systematic genome-wide characterization of ABC transporters in Morchellasextelata remains largely unexplored. Here, a total of 33 ABC transporter genes were identified in M. sextelata and classified into eight subfamilies: ABCA (1), ABCB (7), ABCC (5), ABCD (6), ABCE (1), ABCF (4), ABCG (7), and ABCI (2), based on the features of domain…
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Check each original source for its methods, release status, limitations, and supporting data. A repository announcement, a preprint, and a published study provide different kinds of evidence. SYMTRI’s subject classification helps discovery; it does not independently validate the source’s claims.
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