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Earlier sources: Science
Science investigates the natural world through observation, experiments, and mathematical models. Explore papers and developments in biology, medicine, materials, neuroscience, physics, climate, and mathematics; a reported finding is not necessarily established consensus.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗1452 classified signals in the fourteen-day window. Recent momentum: steady. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- Europe PMC · Published · First archived
High-throughput serial two-photon tomography with BakingTray and BrainSaw ↗
Volumetric imaging is increasingly important in fields such as neuroscience, where quantifying structure and mapping features are inherently three-dimensional problems. Block-face serial two-photon tomography (STPT) has emerged as a powerful approach for high-resolution, whole-organ volumetric imaging. STPT avoids complex sample preparation and balances image quality, speed, and scalability. However, STPT remains niche, in part because of the absence of flexible, general-purpose control software. Here we present BakingTray, an open-source software platform for STPT that extends ScanImage. Baki
- Europe PMC · Published · First archived
The molecular basis of hard cornification in the keratinized jaw sheaths and keratodonts of anuran tadpoles ↗
Hard cornification is the developmental process that produces the hardened epidermal structures that characterize tetrapod diversity, including scales, feathers, hair, and claws. This process relies on keratin proteins and additional reinforcing proteins that assemble, cross-link, and strengthen tissues to become mechanically resilient. Although the molecular composition of hard cornified tissues is known to vary among tetrapods, the program is least understood in amphibians. Within frogs, hard cornification occurs in the mouthparts of most tadpoles and in the nuptial pads, hindfoot claws, and
- Europe PMC · Published · First archived
Heterogeneous evolution of effective recombination landscapes across percomorph fishes ↗
Recombination shapes allelic combinations across the genome and plays a central role in adaptation and speciation. While recombination rates are known to vary and evolve, how recombination landscapes diverge between populations and which processes drive this divergence remains poorly understood. Here, we use the Population Recombination Divergence Index (PRDI) to quantify divergence in effective recombination landscapes between seven pairs of populations and species from four percomorph fish lineages (cichlids, sticklebacks, killifish, and clownfish). While accounting for stochasticity and con
- Europe PMC · Published · First archived
GWAS of flag leaf primary metabolites uncovers metabolic QTL hubs linked to grain yield stability under drought in field-grown indica rice ↗
Reproductive stage drought disrupts flag leaf metabolism in rice (Oryza sativa), limiting photoassimilate translocation to developing grains and reducing grain yield (GY). How natural variation in this response relates to GY remains poorly understood. This study combines untargeted metabolomics of flag leaves from 271 indica rice accessions grown under well-watered (WW) and reproductive-stage water-limited (WL) field conditions with genome-wide association studies of 89 annotated polar metabolites. A total of 180 metabolite quantitative trait loci (mQTLs) were identified: 93 detected only unde
- Europe PMC · Published · First archived
Complete pangenome graph annotation with GrAnnoT and GrAPEx ↗
Background: Pangenome variations graphs (PVG) are promising structures to study diversity and reduce reference bias in genomics. However, it is not currently possible include complete annotation of the PVG. In a previous work, we introduced GrAnnoT, a tool for transferring the annotation from a reference genome to a PVG, and from a PVG to its embedded genomes. However, GrAnnoT was limited to transferring one annotation to the graph, and thus could not include all genes. Results: We implemented new options to GrAnnoT, that can now handle annotations of multiple genomes, and integrate them in th
- Europe PMC · Published · First archived
Harnessing historical collections to reconstruct the invasion history of Microstegium vimineum (Poaceae) ↗
The evolutionary processes underlying successful invasions are often difficult to disentangle. Historical collections provide a temporal perspective, offering great potential to reconstruct invasion histories and identify the processes driving invasions. Japanese stiltgrass (Microstegium vimineum) is an invasive C4 grass introduced to eastern North America over a century ago and now established in 31 USA states. To reconstruct its invasion history, we leveraged low-coverage whole-genome sequencing of 142 herbarium and 330 contemporary samples spanning the temporal and spatial extent of the Nor
- Europe PMC · Published · First archived
Genomic Consequences of Altered Flood Regimes: Gene Flow and Adaptation in a Threatened Floodplain Plant ↗
Floodplains are highly dynamic ecotones where species persistence depends on synchrony between natural flow regimes and life-history. Artificial river engineering has profoundly altered these systems by reducing the frequency and magnitude of spring floods while increasing the unpredictability of flood timing and intensity during summer. These hydrological changes have disrupted historical patterns of dispersal, growth, reproduction, and competitive success among floodplain specialists. Effective conservation in these ecosystems therefore requires understanding how human-altered flow regimes h
- Europe PMC · Published · First archived
A 23-copy tandem repeat of a cytochrome P450 gene underlies an adaptive introgression breakthrough in Ciona intestinalis ↗
Introgression between highly divergent species is generally selected against, yet some foreign alleles can break through species barriers when they provide a sufficient selective advantage, a process known as adaptive introgression. Here, we characterize the structural variant underlying adaptive introgression from Ciona robusta into C. intestinalis, two species separated by 14.5% net molecular divergence. Previous work identified a narrow peak of C. robusta ancestry on chromosome 5 that reached high frequency in several C. intestinalis populations despite otherwise restricted introgression. U
- Europe PMC · Published · First archived
Functional modelling of human infertility-associated genetic variants using C. elegans and mice ↗
Infertility affects one in six couples worldwide and has a significant genetic component. Genome sequencing efforts have identified increasing numbers of potentially pathogenic variants, including in conserved meiotic genes. However, the lack of functional validation remains a major barrier to establishing variant pathogenicity and clinical diagnoses. Here, we establish an experimental pipeline integrating C. elegans and mouse in vivo models with in silico protein structure predictions to functionally validate potentially pathogenic infertility-associated variants. Using CRISPR-Cas9 we generat
- Europe PMC · Published · First archived
A bifunctional RNase H protein supports DNA replication and transcription in nucleus-forming Chimalliviridae phages ↗
Jumbo bacteriophages of the Chimalliviridae family replicate their genomes within a proteinaceous phage nucleus that spatially segregates viral DNA replication and transcription from translation. While the phage nucleus protects viral DNA from host defenses, it also imposes unique constraints on genome replication and gene expression. Here we identify the phage-encoded protein Rhc (RNase H-clamp) as a central mediator of genome transactions within the phage nucleus. Using the Escherichia coli infecting bacteriophage Goslar, we show that Rhc functions as an essential component of a non-canonica
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