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Earlier sources: Science
Science investigates the natural world through observation, experiments, and mathematical models. Explore papers and developments in biology, medicine, materials, neuroscience, physics, climate, and mathematics; a reported finding is not necessarily established consensus.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗1614 classified signals in the fourteen-day window. Recent momentum: steady. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- Hacker News · Posted on Hacker News · First archived
The feedback loop of mathematics research ↗
Hacker News discussion.
- arXiv · Published · First archived
Digital Twin Modeling of Quantum Dynamical Systems: Dissipative Quantum Reservoir Computing ↗
Modeling the response of driven many-body quantum systems from input--output data is difficult: the dynamics are nonlinear, history dependent, and expensive to simulate as system size grows. A paradigmatic case is High-Harmonic Generation~(HHG), where a strong field drives a medium to emit radiation that is highly sensitive to the drive and encodes long-range temporal correlations. We introduce a dissipative quantum reservoir computing~(DQRC) framework that builds a digital twin of such a system, learning its input--output map directly from data while the reservoir---itself a small open quantu…
- Hacker News · Posted on Hacker News · First archived
Bananas That Don't Go Brown to Hit Supermarkets Thanks to DNA Editing ↗
Hacker News discussion.
- OpenAlex · Published · First archived
Glucuronyl Glucosyloleanolate, an AI-Discovered Saponin: From Melanocyte Assays to Clinical Skin Lightening-Brightening in a Multi-Ethnic Panel ↗
Most of the depigmenting active ingredients currently in use work by inhibiting the catalytic activity of tyrosinase, and several of them are now subject to increasingly stringent regulatory and tolerance requirements. Glucuronylglucosyloleanolate (GGO), a natural triterpene saponin, was identified from public compound databases using an AI-based discovery platform combining in-silico predictions, physchem parameters and market requirements; and was subsequently subjected to a series of stepwise experiments. In normal human epidermal melanocytes, GGO reduced melanin production by up to 86% at…
- OpenAlex · Published · First archived
Egg white protein alleviated high-fat-diet-induced obesity in mice by modulating lipid metabolism and gut microbiota: novel insights into synergistic effect ↗
Abstract Egg white protein (EWP) is considered an optimal dietary protein for weight management due to its superior amino acid profile, high biological value, and diverse metabolic regulatory functions. The study explored the effects of EWP on lipid metabolism in high-fat diet (HFD)-induced obese mice through transcriptomic and gut microbiota analyses. These results showed that EWP intake significantly influenced body weight, adipose tissue, and glucose tolerance in obese mice. EWP-1200 reduced blood lipid characteristics, decreased adipocyte size and improved hepatic injury. Moreover, EWP sup…
- OpenAlex · Published · First archived
Conventional and Quantum Feature Selection and Federated Learning Applications for Anomaly Detection in IoT Healthcare Networks ↗
Privacy is a major concern in the Internet Healthcare of Things (IoHT), where threat actors may intrude systems to access personally identifiable data. Federated Learning (FL) is a well suited Machine Learning (ML) approach to preserve confidentiality, availability, and integrity in such settings during data analysis. In this work, we introduce a Network of Quantum ML (N-QML) approach for IoHT intrusion detection, integrating quantum PCA (QPCA) with Quantum FL (QPCA+QFL), tested on a subset of the data set WUSTL-EHMS-2020 using classical and quantum computing experiments across three seeds, co…
- OpenAlex · Published · First archived
Enhanced physics-informed neural networks for Vlasov–Poisson simulations ↗
Kinetic theory is one of the fundamental descriptions in plasma physics. Large-scale numerical simulations for kinetic models such as the non-relativistic Vlasov–Poisson system and the Vlasov–Maxwell system are computationally demanding. To save computer resources, this work uses physics-informed neural network (PINN) and its variant separable PINN (SPINN) to approach the Vlasov–Poisson system. We constructed PINN and SPINN solvers for the multi-dimensional Vlasov–Poisson system and implemented the simulation of Landau damping and two-stream instabilities. The SPINN is proved to be effective f…
- OpenAlex · Published · First archived
Synthetic biology resurrects bacterial cancer therapy ↗
Engineered bacteria are being developed as living cancer therapeutics that can localize to selected tumor niches, produce payloads in situ, remodel the tumor microenvironment, and engage antitumor immunity. Their clinical translation has nevertheless been limited by heterogeneous colonization, attenuation-related loss of fitness, host clearance, uncertain pharmacology, and product-control challenges. To complement recent landscape reviews, this article applies a design-to-translation framework that links chassis selection, genetic control, delivery route, tumor and microbial ecology, human pha…
- OpenAlex · Published · First archived
Comparable clinical outcomes and redislocation rates after isolated medial patellofemoral ligament reconstruction in patients with and without borderline anatomical risk factors for patellar instability ↗
Abstract Purpose The purpose of this study was to compare mid‐ to long‐term clinical outcomes and redislocation rates after isolated medial patellofemoral ligament (MPFL) reconstruction in patients with and without borderline anatomical risk factors. It was hypothesized that isolated MPFL reconstruction would provide comparable outcomes regardless of borderline anatomical abnormalities. Methods A retrospective comparative study was performed on 51 patients (55 knees) treated with isolated MPFL reconstruction for recurrent patellar instability between 2013 and 2023. Patients were divided into a…
- OpenAlex · Published · First archived
Development of G Protein-Coupled Receptor 183 Benzimidazole Antagonists Utilizing a Core-Hopping Approach ↗
G protein-coupled receptor 183 (GPR183, EBI2) has emerged as a promising therapeutic target for neuropathic pain due to its role in neuroinflammatory signaling. Previously, our group identified SAE-14 as a potent GPR183 antagonist and lead scaffold for analgesic development. To further explore the structural requirements for receptor antagonism, a ligand-based core-hopping strategy was employed to identify novel chemotypes derived from SAE-14. Virtual screening identified a trisubstituted benzimidazole scaffold as a promising candidate for further investigation. A focused series of benzimidazo…
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How to assess evidence about Science
Check each original source for its methods, release status, limitations, and supporting data. A repository announcement, a preprint, and a published study provide different kinds of evidence. SYMTRI’s subject classification helps discovery; it does not independently validate the source’s claims.
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