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Earlier sources: Science
Science investigates the natural world through observation, experiments, and mathematical models. Explore papers and developments in biology, medicine, materials, neuroscience, physics, climate, and mathematics; a reported finding is not necessarily established consensus.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗1616 classified signals in the fourteen-day window. Recent momentum: steady. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- OpenAlex · Published · First archived
Low-carbon core-shell cold-bonded lightweight aggregates using expanded polystyrene and limestone calcined clay cement: Particle-scale performance, sustainability, and physics-informed prediction ↗
Cold-bonded core-shell lightweight aggregates (CSLWAs) using an expanded polystyrene (EPS) core with a limestone calcined clay cement (LC3) shell offer a promising route to low-carbon lightweight aggregates; however, the coupled effects of core size, shell thickness, LC3 composition, and curing regime on particle-scale performance remain insufficiently understood. This study develops EPS-LC3-based CSLWAs by combining three discrete EPS core diameters (8, 10, and 12 mm) with three LC3 shell binders of 30%, 50%, and 70% cement content (denoted LC30, LC50, and LC70). The aggregates were cured und…
- OpenAlex · Published · First archived
The genome sequence of the Warted Knot-Horn moth, Acrobasis repandana Fabricius, 1798 ↗
We present a genome assembly from an individual female specimen of Acrobasis repandana (Warted Knot-Horn moth; Arthropoda; Insecta; Lepidoptera; Pyralidae). The genome sequence has a total length of 620.40 megabases. Most of the assembly (99.78%) is scaffolded into 32 chromosomal pseudomolecules, including the Z and W sex chromosomes. The mitochondrial genome has also been assembled and is 15.21 kilobases in length. Gene annotation of this assembly on Ensembl identified 11,522 protein-coding genes.
- OpenAlex · Published · First archived
A simulator-based quantum framework for molecular dynamics and multiscale materials modeling ↗
Introduction: Quantum computing has the potential to transform scientific computing by providing efficient algorithms for solving large-scale numerical problems that arise in engineering and materials science. However, integrating quantum algorithms into multiscale mechanics remains largely unexplored due to the complexity of coupling atomistic and continuum models and the nonlinear nature of molecular dynamics. In this work, we develop a unified hybrid classical–quantum framework for molecular dynamics and multiscale materials modeling based on the Variational Quantum Linear Solver (VQLS). Ma…
- OpenAlex · Published · First archived
Conserved and Tissue‐Specific RNA and Protein Cargos of Small Extracellular Vesicles From 120 Tissue Sites Across 34 Organs in a Single Pig ↗
ABSTRACT Small extracellular vesicles (sEVs) carry diverse cargo essential for intercellular communication, but their organism‐wide characterization across all tissues is still limited. Here, we present a multi‐omics sEV atlas covering the whole‐body of 120 tissue sites, four body fluids and nine gastrointestinal contents from the same pig. We identified 7995 proteins, 337 miRNAs as well as 105,409 transcripts (93,409 full‐length) in sEVs by mass spectrometry, next‐ and third‐generation RNA sequencing. Among these, a conserved cargo set of 252 proteins, 18 miRNAs and 1227 transcripts was defin…
- OpenAlex · Published · First archived
The effect of nutritional support on clinical disease progress and malnutrition in inflammatory bowel patients ↗
Abstract Individuals with inflammatory bowel disease (IBD) are at continuous risk of malnutrition, which significantly impacts their prognosis. This study aimed to evaluate the effects of a high-protein diet (HPD) and a high-protein enteral-supplemented diet on disease severity and nutritional status in IBD patients. Forty-eight IBD patients with malnutrition (18–64 years) were assigned to a HPD ( n 24) or a high-protein enteral-supplemented diet ( n 24) for 12 weeks. Nutritional Risk Screening (NRS-2002), disease activity (CDAI/Mayo) and anthropometric parameters were evaluated at baseline, w…
- OpenAlex · Published · First archived
Five-year availability of early antibiotic-specific susceptibility results for Enterobacterales and their clinical actionability in intensive care ↗
Abstract Early availability of microbiological identification and antimicrobial susceptibility of Enterobacterales may support timely antimicrobial decision-making. The objectives were (i) to describe the cumulative antimicrobial susceptibility patterns of Enterobacterales ; (ii) to evaluate the ability of the BD Phoenix M50 antimicrobial susceptibility testing (AST) system to generate same-day results in Enterobacterales ; (iii) to assess the clinical impact of rapid Enterobacterales identification by MALDI-TOF combined with the same-day AST by M50 in an intensive care unit (ICU) setting. A r…
- OpenAlex · Published · First archived
Post-measurement readout and class-resolved hardware sensitivity of a variational quantum classifier on two IBM Heron r2 backends ↗
Variational quantum classifiers (VQCs) are increasingly evaluated on real quantum processors, yet their deployment behaviour can depend on post-measurement readout and variation across independently trained models. We study a four-qubit VQC for three-class traffic-state classification on two IBM Heron r2 backends. In a single-seed comparison, a four-channel linear-projection readout achieves higher clean balanced accuracy than a three-channel direct-argmax readout (94.4% versus 78.9%), whereas their hardware recoveries on ibm_kingston are 53.0% and 94.4%, respectively. A matched synthetic-nois…
- OpenAlex · Published · First archived
Genome-wide identification of the YABBY gene family in wax gourd (Benincasa hispida) and functional analysis of BhYAB2 in fruit and leaf development ↗
Abstract Background The YABBY transcription factor family plays a central regulatory role in lateral organ morphogenesis in plants, yet its functions in wax gourd ( Benincasa hispida ) remain poorly understood. Results Eight BhYAB genes belonging to five subfamilies were identified in the wax gourd genome, each closely related to homologous proteins of Arabidopsis thaliana and other cucurbits. Gene structure and conserved motifs were highly conserved within the family, and the promoters contained multiple hormone-responsive elements. BhYAB2 , the member with the most fruit-specific expression…
- OpenAlex · Published · First archived
One-Step Protein Half-Life Estimation from Irreversible Inhibition and Degradation Time Courses ↗
Abstract The half-life of proteins plays a pivotal role in understanding their stability, turnover rate, and functional lifespan within a cell. In this work, we analyze the turnover equation for irreversible protein modifications, such as those occurring during covalent inhibition and targeted protein degradation by PROTACs or molecular glue degraders. Based on this analysis, we introduce a formula for straightforwardly determining protein half-life directly from the time course of unmodified protein. This approach offers a practical and efficient alternative for estimating half-lives, complem…
- OpenAlex · Published · First archived
TCR–mTORC1 signaling promotes epigenetic stabilization of Foxp3 expression in regulatory T cells via TET protein translation ↗
Regulatory T (Treg) cell differentiation and function rely on stable expression of the master transcription factor Foxp3. While Foxp3 expression is epigenetically stabilized through DNA demethylation of a Foxp3 enhancer (the Treg-specific demethylated region, TSDR), the mechanisms underlying this process remain unclear. Here, we show that strong and sustained T cell receptor (TCR) signaling promotes TSDR demethylation, stabilizes Foxp3 expression, and confers suppressive activity in in vitro–induced Treg (iTreg) cells through activation of mTORC1. Mechanistically, TCR–mTORC1 signaling promotes…
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Check each original source for its methods, release status, limitations, and supporting data. A repository announcement, a preprint, and a published study provide different kinds of evidence. SYMTRI’s subject classification helps discovery; it does not independently validate the source’s claims.
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