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Earlier sources: Science
Science investigates the natural world through observation, experiments, and mathematical models. Explore papers and developments in biology, medicine, materials, neuroscience, physics, climate, and mathematics; a reported finding is not necessarily established consensus.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗1620 classified signals in the fourteen-day window. Recent momentum: steady. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- OpenAlex · Published · First archived
A physics-guided machine learning approach to screening spectral induced polarization measurements ↗
Spectral induced polarization (SIP) measurements are increasingly used in time-lapse monitoring studies and require consistent quality control before interpretation. SIP spectra are information-rich but susceptible to acquisition artifacts, noise, and nonphysical behavior, making reliable screening essential before spectra are used to infer material or process changes. Existing approaches rely largely on manual expert review or automated classifiers that do not explicitly evaluate physical plausibility. Here, we develop a physics-guided machine-learning workflow for raw SIP quality control tha…
- OpenAlex · Published · First archived
Aharonov–Bohm interference in a $${\pmb{\mathbb{Z}}}_{\bf{2}}$$ lattice gauge theory on a hybrid qubit–oscillator quantum computer ↗
Abstract Lattice gauge theories, which have both dynamical matter and gauge fields, are strongly coupled problems that lie beyond the reach of classical computation. Quantum simulations may provide a tractable approach for studying lattice gauge theories, but implementing gauge-invariant encodings and real-time evolution remains experimentally challenging. Here we demonstrate a resource-efficient encoding of a $${{\mathbb{Z}}}_{2}$$ Z 2 lattice gauge theory using a hybrid qubit–oscillator trapped-ion quantum device, with the qubits representing the gauge fields and the vibrational modes of the…
- OpenAlex · Published · First archived
BCAM-AKT2 fusion protein promotes unfolded protein response driven oncogenic signaling in SKOV3 epithelial ovarian cancer cell line ↗
In view of the rapidly increasing evidence that gene fusion mutations are frequent drivers of cancer, a deeper understanding of the molecular and functional hallmarks of specific gene fusions in epithelial ovarian cancer (EOC) is essential. In this work we sought to identify the molecular signature of the BCAM-AKT2 fusion protein in ovarian cancer cell lines and to assess the biological impact of the novel fusion in these cells. Our in-vitro results show that the BCAM-AKT2 fusion protein is engaged in proliferative action within EOC cell lines. Furthermore, RNA-seq analysis shows that the effe…
- OpenAlex · Published · First archived
FACT–(H3-H4) complex stimulates Pol α activity to coordinate DNA synthesis with nucleosome assembly ↗
DNA replication is an exquisitely regulated process that requires tight coordination at the eukaryotic replication fork, operating within the compacted chromatin environment. Minimizing exposure of naked DNA is critical to prevent nuclease degradation and genome instability, a hallmark of cancer. Cells, therefore, require a surveillance mechanism that links nucleosome assembly status to DNA replication. Here, we show that histone H3-H4 delivered by the chaperone facilitates chromatin transaction (FACT) directly stimulates the DNA polymerase activity of the polymerase α (Pol α, primase-polymera…
- OpenAlex · Published · First archived
Nutritional Accuracy and Clinical Applicability of Large Language Model-Generated Therapeutic Diet Plans for Phenylketonuria: A Comparative Simulation Study ↗
Background: Large language models (LLMs) are increasingly used to generate nutrition-related recommendations, but their reliability for therapeutic diets requiring precise nutrient control remains uncertain. This study evaluated AI-generated one-day diet plans for standardized simulated cases of classical phenylketonuria (PKU). Methods: Eight standardized simulated cases representing infancy, adolescence, adulthood, and maternal PKU were evaluated. Between 8 and 10 February 2026, ChatGPT-5.2, Claude 4.5, and Gemini 3 were each used through their standard consumer-facing chat interfaces to gene…
- OpenAlex · Published · First archived
Hypoglycemic Effect of Hemp Seed Cake Protein Hydrolysates in Streptozotocin-Induced Diabetic Mice ↗
The potential of plant-based bioactive peptides to be used as an alternative or complementary therapy for the safe management of metabolic diseases such as diabetes is garnering increasing attention. In this in vivo study, the hypoglycemic effect of bromelain hydrolysates of hemp seed cake protein is analyzed in streptozotocin-induced diabetic mice. The results demonstrate that treatment of mice with the hydrolysate at a dose of 200 mg/kg/day for 4 weeks leads to a significant decrease in blood glucose levels (by 39%), serum triglyceride levels (16.44%), total cholesterol (13.50%), and low-den…
- OpenAlex · Published · First archived
Protein-enriched soups as a practical strategy to meet protein needs in older adults ↗
Soups are routinely included in home-delivery meals for the elderly, making them an effective vehicle for increasing protein intake in this population at risk of malnutrition. Adequate protein and essential amino acids, particularly branched-chain amino acids (BCAAs), are critical for preserving muscle mass in this group, prompting this study to examine whether enriching vegetable-based soups could improve their nutritional quality. Five soups (pumpkin, lentil, chickpea, mushroom, and split pea) were enriched with animal-derived ingredients, including ham, La Vache qui rit® processed cheeses,…
- OpenAlex · Published · First archived
Multiple strategies to improve the yield of snake thrombin-like enzyme agkihpin from Gloydius halys pallas in Pichia pastoris ↗
Abstract Background In our previous research, we successfully identified agkihpin, a snake venom thrombin-like enzyme (SVTLE) from Gloydius halys pallas . It possesses thrombin-like activity and exhibits multiple functions, including inhibition of tumor invasion and metastasis. Its unique enzymatic properties make agkihpin a promising candidate for thrombolytic and anti-metastatic therapies. In an earlier study, we attempted to produce agkihpin recombinantly in Escherichia coli ( E. coli ). However, the protein was predominantly expressed as inclusion bodies, with low solubility and negligible…
- OpenAlex · Published · First archived
Decentralizing Clinical Tumor Exome Analysis: On-Premises GPU-Based Secondary Analysis in a Clinical Molecular Laboratory ↗
Background/Objectives: Clinical tumor sequencing has become central to precision oncology, yet secondary genomic analysis remains heavily dependent on cloud or centralized computational infrastructure, creating barriers related to cost, turnaround time, data governance, and accessibility. We demonstrate that secondary analysis of clinical tumor exomes can be performed entirely within a clinical molecular laboratory using workstation-class GPU hardware, eliminating dependence on external computational infrastructure. Methods: Sequence data generated off site were analyzed on premises with a var…
- OpenAlex · Published · First archived
Regulating Lipid Metabolism in Cancer: The Therapeutic Potential of Traditional Chinese Medicine ↗
Lipid metabolic reprogramming is a key feature of tumor cells to adapt to the microenvironment and plays an important role in tumor growth, invasion, and metastasis. This article provides a systematic review of the pathological mechanisms underlying lipid metabolism disorders in tumor cells, including abnormalities in fatty acid (FA) and cholesterol metabolism and their association with tumor progression. Furthermore, it summarizes the mechanisms by which traditional Chinese medicine (TCM) and its natural active compounds regulate lipid metabolism through multiple targets and pathways, such as…
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Check each original source for its methods, release status, limitations, and supporting data. A repository announcement, a preprint, and a published study provide different kinds of evidence. SYMTRI’s subject classification helps discovery; it does not independently validate the source’s claims.
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