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Earlier sources: Science
Science investigates the natural world through observation, experiments, and mathematical models. Explore papers and developments in biology, medicine, materials, neuroscience, physics, climate, and mathematics; a reported finding is not necessarily established consensus.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗1646 classified signals in the fourteen-day window. Recent momentum: steady. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- OpenAlex · Published · First archived
PrePssmCas: fusing pre-trained features and PSSM features for Cas protein classification ↗
Abstract Background Clustered regularly interspaced short palindromic repeats (CRISPR) and their associated (Cas) proteins play a vital role in prokaryotic adaptive immune systems, defending against foreign genetic material. However, the classification of CRISPR-Cas systems remains challenging due to limited direct identification techniques. Distinct classes of Cas proteins perform different roles, offering an opportunity for system classification through their identification. The accurate identification of specific Cas proteins is therefore essential for advancing CRISPR-Cas system classifica…
- OpenAlex · Published · First archived
Fermented protein foods as modulators of the gut-muscle axis: mechanisms, evidence, and future directions ↗
Abstract Skeletal muscle has a profound influence on metabolic health, functional capacity and resilience across the lifespan. Beyond dietary protein and physical activity, the gut microbiome may have the capacity to impact skeletal muscle mass and function through the bidirectional network termed the gut-muscle axis (GMA). Fermented protein foods (FPFs) are protein rich matrices transformed by microbial activity that integrate modified protein structures, bioactive peptides, and live microorganisms, or components thereof, which could modulate skeletal muscle physiology. Here, we review mechan…
- OpenAlex · Published · First archived
RCSB PDB AI Help Desk: retrieval-augmented generation for protein structure deposition support ↗
Abstract Motivation Structural biologists have contributed more than 260,000 experimentally determined three-dimensional structures of biological macromolecules to the Protein Data Bank. Incoming depositions are validated and biocurated by approximately 20 expert biocurators at the collaborating data centers worldwide. Biocurators at the Research Collaboratory for Structural Bioinformatics Protein Data Bank, who process more than 40% of global depositions, face growing difficulty sustaining efficient Help Desk operations, having received roughly 19,000 depositor messages across some 8,000 entr…
- OpenAlex · Published · First archived
Qubit-parity interference despite unknown interaction phases ↗
Abstract Quantum interference between interacting systems is fundamental to basic science and quantum technology, but it typically requires precise control of the interaction phases of lasers or microwave generators. Can interference be observed if those interaction phases are stable but unknown, usually prohibitive for complex state without active control? Here, we answer this question by experimentally preparing a Schrödinger-cat-like state of an internal qubit and a motional oscillator of a trapped 40 Ca + ion, and its robustness to such uncontrolled phases. By applying alternating red and…
- OpenAlex · Published · First archived
Multimode and Random-Access Optical Quantum Memory via Adiabatic Phase Imprinting ↗
A photonic quantum memory that can store multiple qubits and later recall any randomly chosen subset is essential for large-scale quantum networking and computing. This capability, similar to random-access memory in classical computers, has been difficult to achieve due to the lack of a versatile random-access mechanism and the limited multi-mode storage capacity of existing quantum memory protocols. One promising route uses photon-echo protocols, which apply optical rephasing pulses to selectively read out frequency-multiplexed photonic qubits within a broadened optical transition. Here we ad…
- Europe PMC · Published · First archived
Testis-predominant gene Mfap3l is dispensable for spermatogenesis under physiological conditions. ↗
The microfibril-associated protein (MFAP) family members play critical roles in extracellular matrix (ECM) assembly and tissue homeostasis maintenance. Among them, MFAP3L (microfibril-associated protein 3-like), a paralog of MFAP3, is predominantly expressed in testicular tissue. Conventional hypotheses propose that it may participate in spermatogenesis by regulating ECM remodeling; however, direct functional evidence and mechanistic insights remain limited. To test this hypothesis, we generated a systemic Mfap3l knockout mouse model using the clustered regularly interspaced short palindromic
- arXiv · Published · First archived
Weather and Climate Without Fluid Mechanics ↗
Even if it were possible, attempting to model the motion of a fluid in a pipe by tracking each individual molecule would be an extraordinary waste of computation. The emergent laws of fluid mechanics accomplish the same goal on a laptop instead of a datacenter. But a sufficiently complex fluid such as in Earth's atmosphere again requires a datacenter, this time to resolve the many contortions in the fields making up our weather. Might there be some analogous set of emergent laws that would represent the effect of these perturbations without needing their explicit representation on a numerical…
- Hacker News · Posted on Hacker News · First archived
Opus 5.5 refuses basic molecular biology questions ↗
Hacker News discussion.
- arXiv · Published · First archived
Toward Actionable Predictability of Tropical Mesoscale Convective Systems through Large-scale Recurrent Environments in Northern South America ↗
Mesoscale convective systems (MCSs) produce much of the extreme precipitation, floods, and landslides that affect northern South America (NOSA), yet remain difficult to anticipate because they are strongly governed by local processes. On the night of 31 March 2017, an MCS triggered a catastrophic flash flood in Mocoa, Colombia ---an event whose severity was not foreseen with sufficient lead time for emergency action, which typically requires several hours to a couple of days. Motivated by this disaster, this study investigates whether such events emerge within recurrent environments that provi…
- arXiv · Published · First archived
Understanding Perturbed Parameter Ensemble Sensitivities Using A Contrastive Learning Approach ↗
Perturbed parameter ensembles (PPEs) reveal how physics parameters affect climate simulations, but interpreting parameter sensitivities across multivariate, spatially structured outputs remains challenging, particularly when calibrating models against observations. We develop an explainable contrastive learning model that maps 5 monthly cloud and radiation fields into a shared representation space. We train the model on the fields of two 100-member Community Atmosphere Model version 6 (CAM6) PPEs, spanning 34 parameters, that only differ in the warm rain microphysics scheme: KK2000, the defaul…
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How to assess evidence about Science
Check each original source for its methods, release status, limitations, and supporting data. A repository announcement, a preprint, and a published study provide different kinds of evidence. SYMTRI’s subject classification helps discovery; it does not independently validate the source’s claims.
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