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Earlier sources: Science
Science investigates the natural world through observation, experiments, and mathematical models. Explore papers and developments in biology, medicine, materials, neuroscience, physics, climate, and mathematics; a reported finding is not necessarily established consensus.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗1687 classified signals in the fourteen-day window. Recent momentum: steady. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- OpenAlex · Published · First archived
Clinical application of trio-based whole-exome sequencing in children born small for gestational age with failed catch-up growth or multisystem anomalies ↗
Abstract Objective To evaluate the molecular diagnostic utility of trio-based whole-exome sequencing (trio-WES) in a clinically selected subgroup of children born small for gestational age (SGA) who had failed catch-up growth and/or multisystem anomalies. Methods We retrospectively studied 99 children born small for gestational age (SGA) who had failed catch-up growth and/or multisystem anomalies. Trio-WES included sequence-variant and copy-number variant (CNV) analysis. Sequence variants were confirmed by Sanger sequencing. CNVs were inferred from trio-WES read-depth data, and parental segreg…
- OpenAlex · Published · First archived
digitalMLPA EZtec-MS: A new highly multiplexed DNA probe-based technique for neonatal screening ↗
Decreasing DNA sequencing costs has paved the way to the use of next generation sequencing (NGS) to expand the number of conditions tested in routine newborn screening (NBS) programs. Expanding NBS programs by NGS, however, raises technical, ethical and economic concerns that are important for low-middle income countries or countries that are hesitant to use sequencing in a public health setting. qPCR-based DNA analyses have already been implemented in routine NBS programs; however, qPCR cannot be highly multiplexed. digitalMLPA (dMLPA) is a highly multiplexed probe-based DNA technique. Here,…
- OpenAlex · Published · First archived
RNA-binding protein CIRBP mediates PKM2 intron retention to negatively regulate multiple myeloma progression and macrophage alternative activation ↗
Multiple myeloma (MM) is a systemic malignancy characterized by the induction of osteolytic lesions. Cold-inducible RNA binding protein (CIRBP) has garnered attention in cancer research due to its dual role as either an oncogene or a tumor suppressor. In this study, publicly available single-cell RNA sequencing data, MM cell lines, and an in vivo xenograft model are utilized to assess the biological significance of CIRBP in MM. Analysis reveals frequent communication between MM cells and macrophages, alongside decreased CIRBP expression in patients. Functionally, CIRBP overexpression in MM cel…
- OpenAlex · Published · First archived
Visualizing Metabolism: Lipid-Based Raman Nanoreporters as an Enabling Platform for Metabolic Imaging and Precision Medicine ↗
Abstract Lipid-based Raman reporters represent a promising but still developing class of metabolic sensors. This review reports lipid nanoparticles and lipid conjugated inorganic nanoparticles as Raman-active systems capable of decoding cellular metabolism with spatial and chemical specificity. It is demonstrated how bioorthogonal reporters operating in the Raman-silent window were incorporated across various modalities such as spontaneous Raman, coherent anti-Stokes Raman spectroscopy, stimulated Raman scattering, surface enhanced Raman spectroscopy, spatially offset Raman spectroscopy, and t…
- OpenAlex · Published · First archived
Genomics of the Genus Rhodiola: From Genome Assembly to High-Altitude Adaptation and Bioactive Compound Biosynthesis ↗
Background/Objectives: The genus Rhodiola comprises alpine medicinal plants renowned for extreme high-altitude adaptability and valuable bioactive compounds. This narrative review synthesizes recent genomic advances to understand how genomic mechanisms contribute to both environmental adaptation and bioactive compound biosynthesis. Methods: This review is a narrative synthesis of genomic studies from the past decade, including chloroplast and nuclear assemblies, comparative genomics of transposable elements and gene families, and integrative multi-omics approaches for pathway elucidation. Resu…
- OpenAlex · Published · First archived
Hypoxia down-regulates METTL3 and WTAP activating Integrin/FAK signaling through m6A/IGF2BP3 dependent manners in TGFBI mRNA to promote pancreatic neuroendocrine neoplasms progression ↗
Hypoxia along with N6-methyladenosine (m6A) plays crucial roles in human tumorigenesis by influencing nearly every aspect of RNA metabolism. Nevertheless, the physiological signals that regulate the equilibrium between methylation and demethylation under hypoxic conditions have yet to be elucidated. Furthermore, the role of m6A methylation-mediated adaptation to hypoxia and the resultant phenotypic shift in pancreatic neuroendocrine neoplasms (pNENs) has not been thoroughly investigated. In this study, we demonstrated a significant reduction in m6A levels in pNENs cells subjected to hypoxia, w…
- OpenAlex · Published · First archived
Simulating quantum measurements without superposition devices ↗
Superposition is the core feature that sets quantum theory apart from classical physics. Here, we investigate whether sets of quantum measurements can be modelled by using devices limited to performing jointly diagonalisable measurements. This leads us to introduce classical measurement models, where many such devices are connected together through classical randomness and post-processing. Such classical measurement models are intermediate between the notion of commutative measurements and joint measurability. Towards understanding these models we (i) identify exact noise and loss rates at whi…
- arXiv · Published · First archived
Learning Prognostic Variables for AI Convective Parameterizations via Symbolic Distillation ↗
Hybrid AI-physics climate modeling aims to improve coarse (~100km-resolution) Earth system models by learning to parameterize subgrid processes from high-fidelity data. However, this so far mostly involves local-in-time, diagnostic parameterizations, in which the subgrid state depends only on the current coarse state with no memory of previous states, which is unrealistic for processes such as convection that have intrinsic persistence. To address this, we enhance local-in-time parameterizations by learning prognostic variables that compactly carry important, additional past information where…
- arXiv · Published · First archived
Toward GPU-Resident Climate Models: A Feasibility Study on Lossy Compression for the Spherical Harmonic Transform's Communication Bottleneck ↗
Operational pseudospectral atmospheric models such as the ECMWF Integrated Forecasting System (IFS) run today almost exclusively on CPUs; GPU ports are under active development but not yet used in production. These models rely on the Spherical Harmonic Transform (SHT). Each time-step requires forward and inverse SHTs, and both passes depend on global pencil transposition that redistribute multi-dimensional arrays across compute nodes. At large node counts these global collectives dominate wall-clock time. We investigate GPU-resident lossy compression, using representative fields from the DYAMO…
- arXiv · Published · First archived
Geodesic Acoustic Modes in pair plasmas confined in tokamak magnetic fields ↗
This paper is devoted to the derivation of the dispersion relation of the Geodesic Acoustic Mode in pair plasmas, i.e. assuming that ions and electrons have the same mass. Geodesic Acoustic Modes are plasma perturbations playing a crucial role in turbulence regulation, and therefore in the determination of the plasma confinement in tokamaks. Experiments with pair plasmas, like electron-positron plasmas, have been proposed with different kinds of confinements, and aim to study fundamental processes in plasma physics and understanding the formation of the early universe.
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