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Earlier sources: Neuroscience
This science thread follows neuroscience through original research, public projects, and source reports. Read the evidence below to see which developments are represented in SYMTRI’s archive.
SYMTRI organizes observations from public sources into a living map. Connections reflect shared subject matter; they do not establish causation or endorse a source.
Open in the map ↗25 classified signals in the fourteen-day window. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- OpenAlex · Published · First archived
A cross-species atlas platform for comparative neuroscience in teleost fish ↗
Abstract Uncovering general principles connecting neural circuits to behaviour requires comparative brain analyses across species. To advance these efforts, we developed a standardised workflow and a unified brain atlas platform for the quantitative comparison of neural structures between two teleost larvae, medaka ( Oryzias latipes ) and zebrafish ( Danio rerio ). Crucially, the platform seamlessly integrates user-generated image volumes, facilitating quantitative comparisons of anatomical, transcriptional, and functional data across species and laboratories. Utilising these integrated tools,…
- OpenAlex · Published · First archived
Alcohol and E-Cigarettes Activate P2X7R in Lung Epithelial Cells, Stimulating Release of Plasminogen Activator in Extracellular Vesicles, Injuring Blood-Brain Barrier ↗
Chronic alcohol and nicotine exposure can increase susceptibility to lung injury and promote the release of extracellular ATP (eATP). Elevated eATP activates the purinergic P2X7 receptor (P2X7R), a membrane ion channel that amplifies inflammatory signaling and promotes extracellular vesicle (EV) release. These EVs may serve as mediators of lung to systemic communications. Proteomic analysis of lung epithelial cell-derived EVs revealed enrichment of urokinase-type plasminogen activator (uPA), a key enzyme involved in extracellular matrix remodeling. Treatment of hPAEpiCs with ETH, acetaldehyde…
- OpenAlex · Published · First archived
The GrimAge clock corresponds to brain ageing and social determinants of health in people with HIV ↗
BACKGROUND: DNA methylation (DNAm)-based epigenetic clocks can measure biological ageing. However, newer epigenetic clocks sensitive to morbidity, mortality, and longitudinal change have not been compared to brain health biomarkers in virally suppressed people with HIV (PWH) and without HIV (PWoH). METHODS: Participants in this case-control study underwent blood draws, brain MRI, and neuropsychological testing. Four DNAm-based epigenetic clocks were calculated: GrimAge (mortality-predictive), PhenoAge (morbidity-sensitive), DunedinPACE (longitudinal), and DNAm telomere length. Clocks were corr…
- OpenAlex · Published · First archived
Temporal metabolic alterations in cerebrospinal fluid-derived small extracellular vesicles following severe traumatic brain injury ↗
Severe traumatic brain injury (sTBI) initiates complex secondary injury mechanisms that evolve over time and are difficult to monitor using current clinical tools. Small extracellular vesicles (sEVs) in cerebrospinal fluid (CSF) represent a promising source for tracking molecular alterations linked to injury progression. We performed untargeted metabolomics profiling of phosphatidylserine-positive sEV-enriched fractions from the CSF of sTBI patients at Days 1, 3, and 5 post-injury, alongside healthy controls. LC-MS revealed distinct temporal alterations, with 53, 77, and 15 differentially abun…
- OpenAlex · Published · First archived
Single-nucleus transcriptome-wide association study of human brain disorders ↗
Abstract Common brain disorders impose a substantial health burden, but localizing their genetic risk in the brain remains challenging 1 . Although genome-wide association studies have identified numerous loci associated with neuropsychiatric and neurodegenerative disorders, many of these loci lie in non-coding regions that influence gene expression in specific cell types 2–5 . Traditional bulk brain transcriptomic analyses, which often focus on European ancestry cohorts, average over cellular diversity, obscuring genetic risk-related changes in gene expression. Here we use single-nucleus gene…
Live window recorded . This is the ingestion observation time, not the publication or discovery date of each source.
How to assess evidence about Neuroscience
Check each original source for its methods, release status, limitations, and supporting data. A repository announcement, a preprint, and a published study provide different kinds of evidence. SYMTRI’s subject classification helps discovery; it does not independently validate the source’s claims.
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