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Earlier sources: Biotechnology
This science thread follows biotechnology through original research, public projects, and source reports. Read the evidence below to see which developments are represented in SYMTRI’s archive.
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Open in the map ↗223 classified signals in the fourteen-day window. These counts include signals awaiting readable evidence.
Earlier sources
Up to ten sources with readable evidence, ordered by their feed timestamp. These archive sources can be older than the live fourteen-day window. This list is a sample, not a measure of total activity. Dates distinguish paper publication, repository creation, model/dataset activity, Hacker News posts, and KEV catalog additions. “First archived” records when SYMTRI first stored the signal.
- OpenAlex · Published · First archived
Thermotolerant Cyberlindnera jadinii Acquired by Adaptive Laboratory Evolution on Ethanol–Acetate for Improved Single-Cell Protein Production ↗
To obtain thermotolerant Cyberlindnera jadinii strains with high-efficiency utilization of ethanol–acetate carbon sources, serial-batch-transfer adaptive laboratory evolution (ALE) under 37 °C was performed on the wild-type strain C. jadinii TU389, and a thermotolerant evolved strain C. jadinii X131 was acquired. Results demonstrated that C. jadinii X131 exhibited superior biomass accumulation compared to the wild-type strain at both the optimal temperature of 31 °C and 37 °C. Specifically, the X131 strain showed 43.4% higher biomass and 45.1% higher protein yield than wild-type strain at 37 °…
- OpenAlex · Published · First archived
A high-quality telomere-to-telomere lumpy skin disease virus genome assembly ↗
Lumpy skin disease virus (LSDV) is an emerging livestock capripoxvirus (CaPV) that continues to cause substantial economic losses across Africa, Asia and Europe. However, important uncertainties remain regarding LSDV genome structure, particularly at the telomeric inverted terminal repeats (ITRs) that are central to host interaction, replication and adaptive evolution. Structural variation at the ITRs is driven by recombination during virus replication. Previous assemblies have relied primarily on short-read sequencing, which provides limited resolution of repeat-rich telomeric regions and pro…
- OpenAlex · Published · First archived
PDI-Spot: A Robust Representation Learning Framework for Identifying Energetic Hotspots in Protein–DNA Complexes ↗
Abstract The binding affinity of protein–DNA complexes is concentrated within a subset of interface residues, called “hotspots”, which are critical for maintaining stable interactions. Therefore, identifying these energetic anchors is essential for elaborating on how mutations disrupt transcriptional regulation and for identifying druggable regions within disease-associated interfaces. In this study, we introduce our novel prediction model, PDI-Spot, that leverages representation learning to capture the complex features of protein–DNA interfaces. Unlike traditional methods that rely on limited…
- OpenAlex · Published · First archived
Draft genome sequence of the halophilic bacterium Chromohalobacter marismortui DSM 6770 T ↗
ABSTRACT Chromohalobacter marismortui DSM 6770 T is a moderately halophilic bacterium isolated from the Dead Sea in 1940. The C. marismortui DSM 6770 T draft genome is 3.55 Mbp, has 3,333 predicted genes, and includes a complete biosynthetic gene cluster for the production of the commercially significant osmoprotectant metabolites ectoine and 5-hydroxyectoine.
- OpenAlex · Published · First archived
Genome-Wide Association Studies and Genomic Selection Analysis for Flowering-Related Traits in Maize Under Salt Stress ↗
Salt stress is a major abiotic stress that restricts the growth and development of maize, often leading to irreversible yield losses when it occurs at flowering. To dissect the genetic basis of flowering-related traits under salt stress, a natural panel of 395 maize inbred lines was phenotyped for days to tasseling (DTT), days to pollen shedding (DTP), days to silking (DTS), and anthesis–silking interval (ASI) under salt-stressed field conditions. All four traits exhibited moderate-to-high heritabilities, ranging from 76.55% to 93.13%, suggesting a substantial genetic basis. GWAS using MLM, Fa…
- OpenAlex · Published · First archived
Three Vibrio isolates from the coral Pachyseris speciosa as draft genome resources ↗
ABSTRACT Vibrio coralliilyticus SCP4, Vibrio harveyi SCP5, and Vibrio sp. SCP2 were isolated from the coral Pachyseris speciosa in Singapore, adding to reports of Vibrio in tropical corals. Their draft genomes variably encode types II, III, and VI secretion systems, toxR , and vcpA , genes linked to pathogenic potential in Vibrio species.
- OpenAlex · Published · First archived
RMND1 dysfunction causes OXPHOS deficiency and alters mitoribosomal protein homeostasis in vivo ↗
Abstract Pathogenic, bi-allelic variants in RMND1 typically manifest as an early-onset multisystemic mitochondrial disease, yet the consequences of RMND1 dysfunction in vivo remain poorly understood. To answer this question, we generated and characterized the first in vivo model of RMND1-related disease, carrying the recurrent p.(Asn238Ser) variant. Homozygous Rmnd1 N238S mice exhibit growth defect, premature mortality, and a multisystem phenotype marked by widespread tissue-dependent defects in oxidative phosphorylation assembly and activity. Quantitative proteomic analysis of Rmnd1 N238S hea…
- OpenAlex · Published · First archived
The genome sequence of the banded centipede, Lithobius variegatus Leach, 1814 ↗
We present a genome assembly from a female specimen of Lithobius variegatus (banded centipede; Arthropoda; Chilopoda; Lithobiomorpha; Lithobiidae). The assembly contains two haplotypes with total lengths of 1,766.49 megabases and 1,768.00 megabases. Most of haplotype 1 (97.68%) is scaffolded into 23 chromosomal pseudomolecules. Haplotype 2 was assembled to scaffold level. The mitochondrial genome has also been assembled, with a length of 17.44 kilobases.
- OpenAlex · Published · First archived
Alternative splicing fine-tunes modular protein interfaces to control protein localization ↗
Alternative splicing provides a pervasive means to expand proteome complexity, yet how it reorganizes protein interactions and cellular localization remains unclear. Here, we show that tissue-regulated longer exons preferably reshape local interaction patterns, whereas microexons fine-tune key interfaces linking distinct cellular processes. Integration of subcellular localization data further indicates that such rewiring can redistribute proteins within cells. By using a high-content imaging approach to systematically evaluate the influence of individual exons on protein localization, we show…
- OpenAlex · Published · First archived
Draft genome sequences of five Escherichia coli strains with human pathogenic attributes from animal reservoirs in the United States ↗
ABSTRACT Both humans and animals harbor commensal Escherichia coli or potentially pathogenic and drug-resistant strains that can cause severe infections. Here, we report draft genomes of five multidrug-resistant E. coli isolates from raccoon, mouse, and cattle in the USA, revealing antimicrobial resistance, virulence-associated genes, and plasmid-associated determinants relevant to One Health.
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How to assess evidence about Biotechnology
Check each original source for its methods, release status, limitations, and supporting data. A repository announcement, a preprint, and a published study provide different kinds of evidence. SYMTRI’s subject classification helps discovery; it does not independently validate the source’s claims.
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